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The identification of biomarkers predicting the burden of brain alpha-synuclein (α-syn) pathology in vivo represents a research priority in Lewy body disease (LBD). Recently, some kinetic parameters of seed amplification assays (SAAs) for α-syn showed associations with measures of clinical progression. However, preanalytical and analytical factors significantly affect these parameters, reducing re
Introduction: Food systems strongly influence both human and planetary health. Unhealthy diets aremajor risk factors for chronic disease and mortality, while food production contributes substantially togreenhouse gas emissions (GHGE), and other negative environmental impacts. Adopting moresustainable dietary patterns, such as the EAT-Lancet diet, has been proposed as part of the solution, butuncer
In June 2024, the community of Roxborough Park, Colorado conducted a wildfire evacuation exercise (or drill for short) that was observed by a team of researchers. This collaborative effort involved residents, community organizers, first responders, emergency managers, and researchers. The drill aimed to test and refine evacuation protocols, communication strategies, and coordination among various
In this note, we prove equicontinuity for the family of one-point densities with respect to a two-dimensional Coulomb gas at an inverse temperature β ≥ 1=2 confined by an external potential of Hele-Shaw (or quasi-harmonic) type. As a consequence, subsequential limiting Lipschitz continuous densities are defined on the microscopic scale. There are several additional results, for example comparing t
Aims/Hypothesis: Charcot foot (CF), a potentially debilitating complication of neuropathy, requires offloading to avoid foot deformities. Follow-up MRI examinations are often used to determine the optimal duration of total contact cast (TCC) offloading treatment. This study investigated the use of follow-up MRI during CF treatment and its relationship to offloading duration and risk of future surg
Dual-fuel engines are a way of transitioning the marine sector to carbon-neutral fuels like hydrogen and methanol. For the development of these engines, accurate simulation of the combustion process is needed, for which calculating the pilot’s ignition delay is essential. The present work investigates novel methodologies for calculating this. This involves the use of chemical kinetic schemes to co
Surface-confined synthesis provides alternative reaction pathways to those utilized within solution-phase chemistry and offers a route to extended molecular architectures with nanoscale dimensions and fascinating magnetic, electronic, and catalytic properties. However, these reaction pathways can be complex multistep processes, containing multiple reactive intermediates. Optimizing the selectivity
Single-master multi-slave (SMMS) teleoperation systems can perform multiple tasks remotely in a shorter time, cover large-scale areas, and adapt more easily to single-point failures, thereby effectively encompassing a broader range ofapplications. As the number of slave manipulators sharing a communicationnetwork increases, the limitation of communication bandwidth becomes critical. To alleviate b
Research on adolescent sexual orientation has expanded in recent decades, yet little is known about its associations with personality traits during this developmental period. This study examined personality dimensions, as measured by the Junior Temperament and Character Inventory, across adolescent sexual orientation groups (asexual, homosexual, heterosexual, bisexual) in a community-based sample
Background and aims: The aim of the present study is to examine the association between parenting practices and adolescent alcohol use in a longitudinal sample of adolescents from Sweden. Data and methods: A prospective longitudinal sample of 3,685 adolescents in a nationwide study in Sweden (2017-2019) filled out questionnaires. Baseline data (T1; 2017) was collected from participants at age 15 t
Background: Gaming disorder is a recently recognized psychiatric condition and a growing public health concern, particularly among adolescents. Despite this, there is limited research on what kind of treatment they need. Existing studies are mostly quantitative and offer limited insight into adolescents' lived experiences.Aim: The aim of this qualitative study is to explore how adolescent patientsBackground: Gaming disorder is a recently recognized psychiatric condition and a growing public health concern, particularly among adolescents. Despite this, there is limited research on what kind of treatment they need. Existing studies are mostly quantitative and offer limited insight into adolescents’ lived experiences. Aim: The aim of this qualitative study is to explore how adolescent patient
Background Nurses constitute a central profession in the cardiac rehabilitation (CR) team delivering comprehensive CR to individuals with cardiovascular disease. We aimed to identify specific components reflecting the nurses' role in the CR team associated with attainment of risk factor targets post myocardial infarction. Methods Center-level data (n = 78) was used from the Perfect-CR study, in wh
Background: It is unclear whether the two device-aided therapies (DATs: deep brain stimulation [DBS] and levodopa–carbidopa intestinal gel [LCIG]) affect personality in patients with Parkinson’s disease (PD). Objective: This retrospective study aims to explore if patients with PD and their close relatives experience any changes in the patient’s personality following the start of DAT. Methods: In t
This chapter describes the core concept sense of coherence (SOC), in terms of definition, measurement, distribution, dimensionality and stability over time. The extensive evidence base of research after Antonovsky died, shows that SOC is a multidimensional and culturally sensitive life orientation. To date, the SOC questionnaire has been used in at least 73 countries all over the world. In additio
Background and purpose: The study aims to evaluate dosimetric properties of hypofractionated treatment plans integrating focal boost, using registered whole-mount histopathology (WMHP) as reference standard. Methods: Fifteen men from the PAMP trial (EudraCT: 2015-005046-55) were included. Participants had ≥ 1 ISUP Grade group ≥ 4 lesion and underwent [68Ga]prostate-specific membrane antigen (PSMA)
