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Epithelial ovarian cancer (EOC) is the most lethal gynecologic malignancy and has a unique metastatic route using ascites, known as the transcoelomic root. However, studies on ascites and contained cellular components have not yet been sufficiently clarified. In this review, we focus on the significance of accumulating ascites, contained EOC cells in the form of spheroids, and interaction with non
I tidigare forskning om narkotika har kvinnor oftast setts som offer och medhjälpare till män, men det finns relativt lite kunskap om hur kvinnor som begår narkotikabrott agerar och resonerar kring sina upplevelser. Syftet med denna rapport är att fånga hur kvinnorna själva förklarar hur och varför de började, fortsatte och i vissa fall slutade eller fortsatt att hantera narkotika.
The assessment of entrepreneurship education outcomes should move beyond a focus on firm creation and associated economic impact to consider a more nuanced view that pays attention to graduates and their entrepreneurial competencies. There is currently limited understanding to what extent entrepreneurial competencies developed through entrepreneurship education are applied in graduates’ subsequent
crataegi Germar, 1824. The first specimen was found in the city of Malmö in the southernmost province of Sweden in the beginning of October 2020, where one individual had taken shelter from a heavy morning rain on a house wall, together with several other beetle species. The species was subsequently sought after during late autumn and winter by sifting litter beneath putative host plants, but it c
The Sun sporadically produces eruptive events leading to intense fluxes of solar energetic particles (SEPs) that dramatically disrupt the near-Earth radiation environment. Such events have been directly studied for the last decades but little is known about the occurrence and magnitude of rare, extreme SEP events. Presently, a few events that produced measurable signals in cosmogenic radionuclides
Many studies have used the relative activities of extracellular enzymes associated with microbial carbon (C), nitrogen (N) and phosphorus (P) acquisition to infer the relative C vs. nutrient limitation of the microbial community. However, recent experimental and theoretical evidence has shown that the use of ecoenzymatic ratio to infer limiting microbial resources may be invalid. We added the two
Mosquitoes use olfaction as a primary means of detecting their hosts. Previously, the functional ablation of a family of Aedes aegypti olfactory receptors, the odorant receptors (ORs), was not sufficient to reduce host seeking in the presence of carbon dioxide (CO2). This suggests the olfactory receptors that remain, such as the ionotropic receptors (IRs), could play a significant role in host det
Med fokus på digitala lärplattformar ställer denna studie frågan: vad är egentligen viktigast för studenterna i den digitala lärmiljön? Vad är den vanligaste anledningen till att studenter upplever att de digitala verktygen ställer till det för dem? Resultatet visar att det finns ett par faktorer som gäller struktur och förståelse av lärarens tanke med kursen som behöver vara uppfyllda för att kur
Inom professionsutbildningar finns inbyggt attstudenterna förr eller senare skall vara kapabla att hanteraautentiska situationer och problem. Därav följer möjligen attdet sätt vi testar studenterna på i examinationen också skallvara så autentiskt som möjligt. I denna text utforskaslitteraturen kring fenomenet autentisk examination, relationentill andra begrepp kring lärande berörs och slutligen re
The function of biomolecules is tightly linked to their structure, and changes therein. Time-resolved X-ray solution scattering has proven a powerful technique for interrogating structural changes and signal transduction in photoreceptor proteins. However, these only represent a small fraction of the biological macromolecules of interest. More recently, laser-induced temperature jumps have been in
Awiggler is a high-power insertion device that was used in the past to produce a smooth wide-band X-ray spectrum. It is widely believed that on low-emittance synchrotrons this X-ray source loses its spatial and spectral homogeneity and therefore becomes less ideal than a scanning undulator. In this paper, we report on experimental and computational studies of an in-vacuum wiggler installed on the
Despite the common challenge of investigating non-metallic inclusions within ultra-high-strength-steel (UHSS) at sub-micrometer scale via conventional methods, probing nitride inclusions at elevated temperatures is vital for guiding steel’ performance. Herein, an in-situ spectro-microscopic determination using advanced Synchrotron X-ray absorption spectroscopy (XAS) coupled with photoelectron emis
Aquaporins (AQPs) are membrane-bound water channels that play crucial roles in maintaining the water homeostasis of the human body. Here, we present a protocol for high-yield recombinant expression of human AQPs in the methylotropic yeast Pichia pastoris and subsequent AQP purification. The protocol typically yields 1–5 mg AQP per g of yeast cell at >95% purity and is compatible with any membrane
Decision-making processes for clean-up of contaminated sites are often highly complex and inherently uncertain. It depends not only on hydrological and biogeochemical site variability, but also on the associated health, environmental, economic, and social impacts of taking, or not taking, action. These variabilities suggest that a dynamic framework is required for promoting sustainable remediation
Joint time-frequency representations are important tools when estimating the instantaneous frequency. The widely used spectrogram is known to have poor energy localisation, which the reassignment method improves. However, the reassignment method is sensitive to noise. In this paper we present a multitaper reassigned spectrogram (MTRS) that is robust to noise and tailored to short duration transien
Background: Swedish Emergency Departments (EDs) see 2.6 million visits annually. Sweden has a strong tradition of health care databases, but information on patients’ pathways to the ED is not documented in any registry. The aim of this study was to provide a national overview of pathways, degree of medical acuteness according to triage, chief complaints, and hospital admission rates for adult pati
In recent years, lipid bicontinuous cubic liquid-crystalline nanoparticles known as cubosomes have been under investigation because of their favorable properties as drug nanocarriers useful for anticancer treatments. Herein, we present organic/inorganic hybrid, theranostic cubosomes stabilized in water with a shell of alternate layers of chitosan, single strand DNA (model genetic material for pote
