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Background: Previous studies suggest an antidepressant effect of omega-3 fatty acids (n-3 PUFAs). This effect may be larger in patients with low-grade inflammation, defined as mild elevations of high sensitivity C-reactive protein or other commonly used inflammatory markers. The antidepressant mechanisms of n-3 PUFAs are not fully understood but may involve modulation of immunometabolic processes
Proper arterial versus venous endothelial lineage identity is required to establish a hierarchical network of arteries and veins and prevent the occurrence of life-threatening arteriovenous malformations. The molecular mechanisms that govern arteriovenous lineage specification remain however incompletely understood. Here, we demonstrate that the transcription factor Prdm16 is expressed in arterial
This thesis investigates the role of trust in the context of decentralised finance (DeFi). Representing a new paradigm shift in finance, DeFi emerge from the technological developments that we have witnessing in the last decades, particularly decentralised ledger technologies (DLTs) of which Blockchain is perhaps the most popular. DeFi is changing the way that firms raise financial capital and a c
Background: Systematic analyses of global health trends can provide an accurate narrative of progress and challenges. We analysed the impact of changing age-specific mortality (epidemiology) and age structure (demography) on crude death rates (CDRs) and causes of death with large or rising mortality to inform the third Lancet Commission on Investing in Health. Methods: Data from the World Populati
Giant number fluctuations (GNFs), whereby the standard deviation ΔN in the local number of particles ⟨N⟩ grows faster than sqrt[⟨N⟩], are a hallmark property of dry active matter systems with orientational order, such as a collection of granular particles on a vibrated plate. This contrasts with momentum-conserving ("wet") active matter systems, such as suspensions of swimming bacteria, where no t
We study the electronic structure of bulk 1T-TaSe_{2} in the charge-density wave phase at low temperature. Our spatially and angle-resolved photoemission data show insulating areas coexisting with metallic regions characterized by a chiral Fermi surface and moderately correlated quasiparticle bands. Additionally, high-resolution laser angle-resolved photoemission reveals variations in the metallic
The dynamics of atmospheric CO2 concentrations during and following the last deglaciation have mainly been ascribed to carbon release from and uptake in oceans, primarily in the Southern Ocean. But recent studies also point toward a terrestrial influence. We quantify dynamic changes to northern terrestrial carbon stocks from the Last Glacial Maximum (21,000 years) until present at millennial time
OBJECTIVES: This is a protocol for a Cochrane Review (intervention). The objectives are as follows: Research objective 1: to assess the effects of different oxygen saturation targets for the delivery room resuscitation of preterm infants. Research objective 2: to assess the effects of different titration strategies for the delivery room resuscitation of preterm infants.
Deep eutectic solvents (DESs) are often promoted as a more environmentally friendly alternative for ionic liquids and other ionic solvents. Like ionic liquids, DESs can be designed for specific tasks in various chemical environments, but their usage in extraction processes is often significantly hampered by difficulties in recovering the extraction product. To remedy this, various tactics are bein
A general formulation for the distribution problem is presented, which is applicable to frequency distributions of subgrid-scale variables and hydrometeor size distributions, as well as to probability distributions characterizing data uncertainties. The general formulation is presented based upon two well-known basic principles: the maximum-entropy principle and the Liouville equation. The maximum
Global environmental challenges, coupled with growing material resource consumption, are exacerbated by an increasingly hostile geopolitical environment and the securitisation of politics. The circular economy (CE) proposes a solution to address these challenges by transforming production and consumption systems, which has sparked significant interest in the concept among scholars, policymakers, a
ObjectivesDespite regularly being found in blood cultures, there are few studies of bloodstream infection (BSI) with Citrobacter. In this population-based study, the aim was to explore patient characteristics, outcome, and incidence in a publicly funded single payer setting.MethodsPatients with growth of Citrobacter in blood culture were identified through the clinical microbiology laboratory in L
Background T-cell activation and clonal expansion are essential to effective immunotherapy responses in non-small cell lung cancer (NSCLC). The distribution of T-cell clones may offer insights into immunogenic mechanisms and imply potential prognostic and predictive information. Methods We analyzed α/β T-cell receptor (TCR) clonality using RNA-sequencing of bulk frozen tumor tissue from 182 patien
Self-care interventions for sexual and reproductive health (SRH), including HIV self-testing, self-injected contraception and self-managed abortion, offer promising pathways to advance universal health coverage, particularly in low- and middle-income countries. While often framed as cost-saving measures, this paper argues that self-care should be understood as a strategic investment in health syst
Introduction Neoadjuvant therapy is the standard of care for the treatment of human epidermal growth factor receptor 2 (HER2)-positive breast cancer (BC). Studies on first-generation antibody-drug conjugates, such as trastuzumab emtansine (T-DM1), showed equal or slightly lower efficacy than chemotherapy combined with dual HER2 blockade. Trastuzumab deruxtecan (T-DXd) is a next-generation conjugat
