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Glioblastoma (GB) is the most common and the most aggressive form of brain tumor in adults, which currently lacks efficient treatment strategies. In this study, we investigated the therapeutic effect of function-blocking antibodies targeting integrin α10β1 on patient-derived-GB cell lines in vitro and in vivo. The in vitro studies demonstrated significant inhibiting effects of the integrin α10 ant
Mast cells (MCs) are multifunctional effectors of the immune system that are distributed in many tissues, often in close association with the basement membrane of blood vessels, epithelium and nerves. Laminins (LMs), a family of large alphabetagamma heterotrimeric proteins, are major components of basement membrane that strongly promote cell adhesion and migration. In this study, we investigated t
Providing humoral immunity, antibody-secreting plasma cells and their immediate precursors, the plasmablasts, are generated in systemic and mucosal immune reactions. Despite their key role in maintaining immunity and immunopathology, little is known about their homeostasis. Here we show that plasmablasts and plasma cells are always detectable in human blood at low frequency in any unimmunized dono
Following vascular injury, basement membrane (BM) components of the blood vessels are exposed to circulating cells and may contribute to hemostasis and/or thrombosis. Laminins 8 (LN-8) (alpha4beta1gamma1) and 10 (LN-10) (alpha5beta1gamma1) are major laminin isoforms of the endothelial BM, and LN-8 is also secreted by activated platelets. In the present study, we demonstrate synthesis of alpha5-lam
The tooth pulp innervation originates from the trigeminal ganglion (TG) and represents an illustrative example of tissue targeting by sensory nerves. Pulpal fibroblasts strongly promote neurite outgrowth from TG neurons in vitro. In the present study, we have investigated the possible participation of laminins (LNs), potent neuritogenic extracellular matrix components. Immunohistochemistry of huma
The tooth pulp has a dense sensory innervation which, upon stimulation, conveys sensory signals perceived as pain. This innervation, which originates from the trigeminal ganglion, is established through a series of regulated steps during development, and represents an interesting example of tissue targeting by pain-specific nerves. We have investigated various potentially neurotrophic and neurorep
Sloth - one of the deadly sins in our life - is here connected to waste handling in historical, recent, and future times. The text is structured in three themes: how waste is hidden and forgotten; waste kept at distance; waste, technology, and shame. It ends with reflections on concepts such as the old deadly sins, rigid as they may be, is worth defending and if they still might speak to a modern Someone who throws away their rubbish on a street-corner or in a ditch is guilty of sloth. This may appear harmless, but seen through the lens of waste management, sloth soon develops into a deadly sin that harms other people’s lives and health. Hiding and forgetting waste has always been a practice with potentially disastrous consequences; buried containers full of toxins will eventually start to
Research Summary: This study explores how traditional craft produces novelty, which appears to be at odds with its emphasis on continuation. While prior research has explored how tradition is rediscovered and revived from the past, traditional craft can produce intrinsic novelty potentially through its own repetitive acts. This study examines a Japanese cuisine Kaiseki, which is traditional but si
The article aims to increase the understanding of how coworkers perform voice (i.e., do voicing) in internal meetings while embedding the phenomenon in wider organizational and social contexts. It answers the following research questions:1. How do coworkers perform voicing in team meetings at an international manufacturing company?2. How do coworkers experience voicing in meetings?The qualitative
In 2008, the Swedish legislature removed any references to race and racial difference,formalizing a post-racial discourse. This has resulted in both the near impossibility ofproving discrimination based on racialized difference, and a formal denial of racial discrimination as a social and structural problem. This article attempts to circumscribe these difficulties by suggesting an approach for tra
This article aims to exemplify how Swedish social partners, especially trade unions, have addressed the issue of in-work poverty in relation to recent and influential changes of the Swedish Employment Protection Act. Applying a methodology where Luhmann’s systems theory is used as a framework of analysis, whereby social partners and trade unions are viewed as organisatiThis article aims to exemplify how Swedish social partners, especially trade unions, have addressed the issue of in-work poverty in relation to recent and influential changes of the Swedish Employment Protection Act. Applying a methodology where Luhmann’s systems theory is used as a framework of analysis, whereby social partners and trade unions are viewed as organisations that contribute to the p
Background: Altered metabolism after liver surgery adds complexity topostoperative pain management. Opioids administered via intravenousPatient Controlled Analgesia (PCA) is one of the main alternatives forinitial pain management. Paracetamol is considered potentially dangerousafter liver surgery but used selectively. This study evaluates whether thereis a difference in patient outcome after hepat
This thesis deals with private international law issues related to the treatment of economic sanctions in international commercial contract disputes in Swedish courts. The dissertation consists of 10 chapters. The first chapter is an introduction. Chapter 10 contains a summary.In Chapter 2, the author examines what economic sanctions are, and in chapter 3, economic sanctions are classified as beloThis thesis deals with private international law issues related to the treatment of economic sanctions in international commercial contract disputes in Swedish courts. The dissertation consists of 10 chapters. The first chapter is an introduction. Chapter 10 contains a summary.In Chapter 2, the author examines what economic sanctions are, and in chapter 3, economic sanctions are classified as belo
