Sökresultat

CD59 is a glycosylphosphatidylinositol (GPI)-anchored cell surface inhibitor of the complement membrane attack complex (MAC). We showed previously that CD59 is highly expressed in pancreatic islets but is down-regulated in rodent models of diabetes. CD59 knockdown but not enzymatic removal of cell surface CD59 led to a loss of glucose-stimulated insulin secretion (GSIS), suggesting that an intrace

In this contribution, we suggest two proposals to achieve fast, real-time lane-keeping control for Autonomous Ground Vehicles (AGVs). The goal of lane-keeping is to orient and keep the vehicle within a given reference path using the front wheel steering angle as the control action for a specific longitudinal velocity. While nonlinear models can describe the lateral dynamics of the vehicle in an ac

Nitrate pollution in groundwater is a serious problem in Shimabara Peninsula, Nagasaki, Japan. A better understanding of the hydrogeochemical evolution of groundwater in vulnerable aquifers is important for health and environment. In this study, groundwater samples were collected at 12 residential and 57 municipal water supply wells and springs in July and August 2018. Nitrate (NO3-N) concentratio

Performance appraisal reports provide vital information for making strategic decisions. Uniting HR practices and IT is an attempt to maximize value creation. Organizations are transforming their performance management systems from traditional to web‐technology based systems to enhance accuracy and objectivity. The present study is an effort to assess employees’ perception of the accuracy of e‐perf

While prior studies have largely addressed corporate social responsibility (CSR) at a macro or institutional level, its importance at the micro or individual level is to date underexplored, especially in the context of developing economies. Further, it is not clear from the studies in the extant literature how the role of females is more important in the context of environmental management as comp

The northernmost population of Acer campestre L. has its distribution in southern Sweden and consists of just 36 individuals. This particular remnant is considered critically endangered (CE) although the species spreads rapidly as potentially invasive gene pools escaped from gardens and urban plantations. The issue to distinguish between indigenous and introduced gene pools is urgent, since indivi

Hodgkin and Huxley's seminal neuron model describes the propagation of voltage spikes in axons, but it cannot explain certain full-neuron features crucial for understanding the neural code. We consider channel current fluctuations in a trisection of the Hodgkin-Huxley model, allowing an analytic-mechanistic explanation of these features and yielding consistently excellent matches with in vivo reco

Context. The detection of a super-Earth and three mini-Neptunes transiting the bright (V = 9.2 mag) star HD 108236 (also known as TOI-1233) was recently reported on the basis of TESS and ground-based light curves. Aims. We perform a first characterisation of the HD 108236 planetary system through high-precision CHEOPS photometry and improve the transit ephemerides and system parameters. Methods. W

Atrial fibrillation is the most common type of cardiac arrhythmia in clinical practice. Currently, catheter ablation for pulmonary-vein isolation is a well-established treatment for maintaining sinus rhythm when antiarrhythmic drugs do not succeed. Unfortunately, arrhythmia recurrence after catheter ablation remains common, with estimated rates of up to 45%. A better understanding of factors leadi

Differential cross-section measurements are presented for the electroweak production of two jets in association with a Z boson. These measurements are sensitive to the vector-boson fusion production mechanism and provide a fundamental test of the gauge structure of the Standard Model. The analysis is performed using proton–proton collision data collected by ATLAS at s=13TeV and with an integrated

Measurements of the Standard Model Higgs boson decaying into a bb¯ pair and produced in association with a W or Z boson decaying into leptons, using proton–proton collision data collected between 2015 and 2018 by the ATLAS detector, are presented. The measurements use collisions produced by the Large Hadron Collider at a centre-of-mass energy of s=13Te, corresponding to an integrated luminosity of

We present part 2 of the sixth and final Data Release (DR6) of the Radial Velocity Experiment (RAVE), a magnitude-limited (9 < I < 12) spectroscopic survey of Galactic stars randomly selected in Earth's southern hemisphere. The RAVE medium-resolution spectra (R ∼ 7500) cover the Ca triplet region (8410-8795 Å) and span the complete time frame from the start of RAVE observations on 2003 April 12 to

The Radial Velocity Experiment (Rave) is a magnitude-limited (9 < I < 12) spectroscopic survey of Galactic stars randomly selected in Earth's southern hemisphere. The Rave medium-resolution spectra (R ∼ 7500) cover the Ca-triplet region (8410-8795 Å). The sixth and final data release (DR6) is based on 518,387 observations of 451,783 unique stars. Rave observations were taken between 2003 April 12

We derive Bayesian distances for all stars in the radial velocity sample of Gaia DR2, and use the statistical method of Schönrich, Binney & Asplund to validate the distances and test the Gaia parallaxes. In contrast to other methods, which rely on special sources, our method directly tests the distances to all stars in our sample. We find clear evidence for a near-linear trend of distance bias

The early stages of a galaxy's evolution leave an imprint on its metallicity distribution. We discuss the origins and evolution of radial metallicity gradients in discs of spiral galaxies using an analytical chemical evolution model. We explain how radial metallicity gradients in stellar populations are determined by three factors: the radial metallicity profile of the star-forming interstellar me

Based on a nationwide register data we recently reported a link between male infertility and increased risk of early onset prostate cancer. However, mortality due to prostate cancer, which can be regarded as the ultimate proxy for its clinical significance, especially in the context of over-diagnosis and over-treatment, could not be explored in the previous study, since the follow-up period in mos

Many countries around the world have a conscience clause allowing physicians and health care providers to opt-out of performing abortions. This practice of conscientious objection to abortion care affects both healthcare providers and women's access to abortion care. In Croatia, a conscience clause was introduced in 2003. Nonetheless, women's experiences of abortion after the introduction have not

Context. Elemental abundance gradients in galactic disks are important constraints for models of how spiral galaxies form and evolve. However, the abundance structure of the outer disk region of the Milky Way is poorly known, which hampers our understanding of the spiral galaxy that is closest to us and that can be studied in greatest detail. Young OB stars are good tracers of the present-day chem

The effectiveness of public health measures to prevent COVID-19 contagion has required less vulnerable citizens to pay an individual cost in terms of personal liberty infringement to protect more vulnerable groups. However, the close relationship between scientific experts and politicians in providing information on COVID-19 measures makes it difficult to understand which communication source was

The atrioventricular (AV) node plays a crucial role during many supraventricular tachycardias (SVT). To better understand its function under these complex conditions, mathematical modelling has emerged as a valuable tool. The model presented here builds on a recently published 1D model of the human AV-node, consisting of a series of interacting nodes, each with separate dynamics in refractory time