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The Scale and Extent of Political Economies of the Middle Bronze Age Jazīrah and the Bilād al-Šām (c. 1800-1600 BCE)

The present thesis investigates the material scale of six political economiesdistributed across the dry-farming plains and piedmonts of the Middle Bronze AgeJazīrah and the Bilād al-Šām. This is done using a comparative and interdisciplinaryapproach combining the large-scale analysis of administrative cuneiform texts withthe compilation of relevant archaeological survey datasets. Drawing on theori

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Reading An Yu’s Poetry (Preface)

Short-term effects of follicle-stimulating hormone on immune function, lipid, and vitamin metabolism in transiently castrated men

Background: Prostate cancer therapy with surgical or chemical castration with gonadotropin-releasing hormone (GnRH) agonists has been linked to elevated follicle-stimulating hormone (FSH) levels, which may contribute to secondary health disorders, including atherosclerosis and diabetes. Although recent findings suggest a role for FSH beyond the reproductive system, its metabolic impact remains unc

Single-cell Sequencing of Acute Leukemia

Acute leukemia affects individuals of all ages and encompasses a heterogeneous group of malignancies driven by genetic alterations that give rise to leukemia stem cells (LSCs), which sustain self-renewal and drive the expansion of abnormal cells. Based on how these alterations affect maturation, acute leukemia is classified into acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL). Acute leukemia affects individuals of all ages and encompasses a heterogeneous group of malignancies driven by genetic alterations that give rise to leukemia stem cells (LSCs), which sustain self-renewal and drive the expansion of abnormal cells. Based on how these alterations affect maturation, acute leukemia is classified into acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL).

Committed leadership : a prerequisite for successful implementation of recovery during the workday

Aim: The aim of this study was to explore the role of managers and employees with an assigned responsibility (i.e. inspirers) when integrating recovery-enhancing activities into everyday work in a primary health care setting. Background: The possibility of recovery during the workday is essential for employee wellbeing. However, the literature on workplace interventions focusing on recovery is sca

Work loss in patients with rheumatoid arthritis treated with abatacept, rituximab, tocilizumab or TNF inhibitors : a nationwide direct drug-to-drug comparison

Objective To compare work loss after starting tumour necrosis factor inhibitors (TNFi), rituximab, abatacept or tocilizumab in patients with rheumatoid arthritis (RA). Methods We used data from the Swedish Rheumatology Quality Register to identify patients aged 19-62 years who were treated with TNFi (n=15 093), rituximab (n=2123), abatacept (n=1877) or tocilizumab (n=1720) between 2007 and 2020. D

Introduction

Putting her watch on her wrist and the phone in her bag, she was ready to leave for work. The secret she was carrying had to be dealt with later. She had not fully decided yet what to do about it. Maybe she should pay the clinic a visit, just have a chat. What could be the harm in that?Once again, he felt constrained in his work. The system did not really fit. It spilled over into his personal lif

The Archaeological Distribution of the Cuneiform Corpus : A Provisional Quantitative and Geospatial Survey

The present study offers a first comprehensive, quantifiable overview of the geographical extent and scale of the cuneiform corpus. Though one of the oldest and longest-lived scripts in history, the sheer size of this corpus, being among the largest discrete bodies of written source material from the pre-modern world, is seldom properly appreciated. We review and evaluate past quantitative assessm

CIGS-AE : A Quantitative Index of Cuneiform Inscriptions

We present an index providing estimates of the number of cuneiform inscriptions derived from individual archaeological locations, along with bibliographical references for these estimates. Archaeological finds of cuneiform inscriptions are known from across Europe, Asia, and Africa, with the present index including an aggregate 430,000 inscriptions distributed across 600 locations. This index can

What contributes to out-of-pocket health expenditure in Cambodia's uncovered population? A distributional and decomposition analysis using survey data

Introduction: Out-of-pocket health expenditures (OOPE) are an inefficient and inequitable means of health financing. Identifying the factors driving these expenditures is crucial to design effective prepayment schemes. This study uses Cambodia—a country with high OOPE and prevalent informal employment—as a case study to analyse the relative contributions of healthcare, health, and social factors t

Enzymatic conversion of galactosylated glycans by gut bacteria : Structural and functional characterisation of carbohydrate-active enzymes

The human gut microbiome is a highly complex environment, where a myriad of intricate microbiota-microbiota and microbiota-host interactions occur. The human gut microbiota has been associated with both health and disease. The research presented in this thesis focuses on investigating how the butyrate-producing human gut bacterium Roseburia hominis A2-183 (R. hominis) processes β-mannan oligosacch

Morphology development during single droplet drying of mixed component formulations and milk

We report on the influence of selected components and their mixtures on the development of the morphology during drying of single droplets and extend the results to the morphology of whole milk powder particles. Sessile single droplet drying and acoustic levitation methods were employed to study single droplet drying. The influence of carbohydrates (lactose and maltodextrin DE12) and proteins (mic

Freeze-dried and re-hydrated liquid crystalline nanoparticles stabilized with disaccharides for drug-delivery of the plectasin derivative AP114 antimicrobial peptide

Liquid crystalline nanoparticles (LCNPs), e.g. cubosomes and hexosomes, are receiving more and more attraction as drug delivery vehicles. Dry powder formulation that forms LCNPs upon hydration can be advantageous to make new routes of administration accessible. In this work, we investigate use of three disaccharides (lactose, trehalose and sucrose) as protective matrices for glycerol monooleate ba