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At the heart of many nucleoside triphosphatases is a conserved phosphate-binding sequence motif. A current model of early enzyme evolution proposes that this six to eight residue motif could have sparked the emergence of the very first nucleoside triphosphatases—a striking example of evolutionary continuity from simple beginnings, if true. To test this provocative model, seven disembodied Walker A
Strong correlation remains a significant challenge for DFT with no satisfying solutions found yet within the standard Kohn-Sham framework. Instead, for decades, a number of different approaches have been suggested to combine the accuracy of multiconfigurational methods with the efficiency of DFT. In this article, we demonstrate that many of these methods are or would be significantly improved by b
Losses and damages from climate change are not just a future risk but already a present reality, and “Loss and Damage” (L&D) as a policy domain has been formalised under the United Nations Framework Convention on Climate Change (UNFCCC), alongside mitigation and adaptation. While climate services currently provide strong support for adaptation and disaster recovery, here we propose that an exp
Background. Young adults starting kidney replacement therapy (KRT) during childhood and reaching their 18th birthday (i.e. adult survivors of childhood KRT) form a challenging population of interest to nephrologists treating adults, as during this period there will be a transition to adult renal centres. Nonetheless, few studies have focused on the epidemiology of KRT in this group. We aimed to pr
Background: Monitoring metabolites of tamoxifen, such as endoxifen, has been suggested as a strategy to ascertain therapeutic effect of tamoxifen therapy, but clinical guidelines are missing. Herein, we aim to investigate the outcome of endoxifen concentrations of low-dose tamoxifen, using change in mammographic breast density as a proxy for therapy response. Methods: In the randomized KARISMA-Tam
Aim: The selective use of defunctioning stomas in anterior resection for rectal cancer hinges on accurately predicting anastomotic leakage. The aim of this study was to develop a prediction model for use in a prospective randomized clinical trial. Method: Colorectal Cancer Database (CRCBaSe) Sweden was used to identify patients who underwent low anterior resection for rectal cancer 2007–2021. Elig
This chapter examines the integration of VR in teaching, focusing on teachers' experiences, perceptions, and challenges. Using a mixed-methods approach, qualitative data from 156 teachers were analyzed with NLP and AI-driven models. The findings show that VR enhances student engagement, motivation, and experiential learning by making abstract concepts accessible and providing risk-free environment
Tonåringar utgör en viktig källa till flexibel och lågavlönad arbetskraft inom servicesektorn. Trots detta saknas forskning som belyser och problematiserar deras sysselsättningsmönster, anställningsvillkor och arbetserfarenheter – särskilt i en nordisk kontext. Denna avhandling analyserar gymnasieelever som arbetskraft i Sverige, i skärningspunkten mellan kundnära servicebranscher som är beroende Teenage students constitute an important source of flexible, low-cost labor in interactive service sectors. However, existing empirical research has primarily treated their labor as transitional, focusing on its impact on future employment or labor market outcomes. There remains a lack of knowledge about how these young workers experience and make sense of their early employment, particularly with
Om Kubakrisen.
Hand-held power tools with high levels of vibration can give rise to hand–arm vibration syndrome, involving chronic nerve and vascular damage. The objective of this study was to identify aspects that could affect the implementation and future use of low-vibration tools in four types of industries: construction, quarrying, steelworks and dental laboratories. Field visits including observations and
