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Heat-shock protein 90 (HSP90) is a molecular chaperone that activates oncogenic transformation in several solid tumors, including lung and breast cancers. Ganetespib, a most promising candidate among several HSP90 inhibitors under clinical trials, has entered Phase III clinical trials for cancer therapy. Despite numerous evidences validating HSP90 as a target of anticancer, there are few studies o

Lichens produce various unique chemicals that are used in the pharmaceutical industry. To screen for novel lichen secondary metabolites that inhibit the stemness potential of colorectal cancer cells, we tested acetone extracts of 11 lichen samples collected in Chile. Tumidulin, isolated from Niebla sp., reduced spheroid formation in CSC221, DLD1, and HT29 cells. In addition, mRNA expressions and p

BACKGROUND: Endolichenic fungi are microbes that inhabit the thalli of lichens and produce various unique chemicals that can be used for pharmaceutical purposes.PURPOSE: This study screened a library of endolichenic fungal extracts to identify novel anticancer agents capable of suppressing the tumorigenicity of human cancer cells.METHODS: Active compounds were isolated from extracts of endolicheni

In 1936, when the Provisional Agreement concerning the Status of Refugees coming from Germany was adopted, the same course was followed: the term refugee covered all persons coming from Germany. The definition of the term refugee was not established by the adoption of the 1967 Refugee Protocol, which created a more or less complete correspondence between the mandate of the UNHCR and treaty law. Fr

This chapter focuses on society's construction in normative terms and, thereby, tries to lay the foundation for a theory based on the strategy of anatomy applied to society. Anatomy is that part of biology that deals with how organisms are built. All living organisms consist of cells that are structured in different types of tissues, which, in turn, build up the organs. Society starts over again f

It is well known that Gaussian polynomials (i.e., q-binomials) describe the distribution of the [Formula presented] statistic on monotone paths in a rectangular grid. We introduce two new statistics, [Formula presented] and [Formula presented]; attach “ornaments” to the grid that scramble the values of [Formula presented] in specific fashion; and re-evaluate these statistics, in order to argue tha

Objective: Huntington's disease (HD) is an inherited neurodegenerative disease with motor, cognitive and psychiatric symptoms. Non-motor symptoms like depression and altered social cognition are proposed to be caused by dysfunction of the hypothalamus. We measured the hypothalamic neuropeptide oxytocin in plasma and cerebrospinal fluid (CSF) in a cohort of HD gene expansion carriers (HDGECs), comp

Imaging is an integral part of breast cancer diagnosis, staging and follow-up. Breast imaging is also important for radiation therapy planning. The radiation oncologist needs to review patient’s imaging (e.g. mammography) to evaluate the extent of disease (for radiation planning, not for diagnostic purposes) and for treatment planning. Pre-treatment imaging is the key for planning radiation target

OBJECTIVES: To evaluate the efficacy of intensive smoking cessation interventions (ISCIs) directly compared with shorter interventions (SIs), measured as successful quitting.METHOD: Medline, Embase, the Cochrane Library and CINAHL were searched on 15 October 2021. Peer-reviewed randomised controlled trials (RCTs) of adult, daily smokers undergoing an ISCI were included. No setting, time or languag

Rabi oscillations are periodic modulations of populations in two-level systems interacting with a time-varying field 1. They are ubiquitous in physics with applications in different areas such as photonics 2, nano-electronics 3, electron microscopy 4 and quantum information 5. While the theory developed by Rabi was intended for fermions in gyrating magnetic fields, Autler and Townes realized that

Dynamic resource management is a difficult problem in modern microservice applications. Many proposed methods rely on the availability of an analytical performance model, often based on queueing theory. Such models can always be hand-crafted, but this takes time and requires expert knowledge. Various methods have been proposed that can automatically extract models from logs or tracing data. Howeve

The design and evaluation of national HIV programs often rely on aggregated national data, which may obscure localized HIV epidemics. In Ethiopia, even though the national adult HIV prevalence has decreased, little information is available about local areas and subpopulations. To inform HIV prevention efforts for specific populations, we identified geographic locations and drivers of HIV transmiss

The haematopoietic stem cell (HSC) is a somatic stem cell essential for life long haematopoiesis; HSCs have the capability to differentiate into all mature types of blood cells and can also undergo self-renewal to maintain their own numbers. They also have the potential to reconstitute a complete haematopoietic system following HSC transplantation, also known as bone marrow transplantation, which