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SPATA2 mediates the recruitment of CYLD to immune receptor complexes by bridging the interaction of CYLD with the linear ubiquitylation assembly complex (LUBAC) component HOIP. Whether SPATA2 exhibits functions independently of CYLD is unclear. Here, we show that, while Cyld−/− and Spata2−/− mice are viable, double mutants exhibit highly penetrant perinatal lethality, indicating independent functi

Induced pluripotent stem cell (iPSC) reprogramming is inefficient and understanding the molecular mechanisms underlying this inefficiency holds the key to successfully control cellular identity. Here, we report 24 reprogramming roadblock genes identified by CRISPR/Cas9-mediated genome-wide knockout (KO) screening. Of these, depletion of the predicted KRAB zinc finger protein (KRAB-ZFP) Zfp266 stro

Introduction: Plasma-measured tau phosphorylated at threonine 217 (p-tau217) is a potential non-invasive biomarker of Alzheimer's disease (AD). We investigated whether plasma p-tau217 predicts subsequent cognition and positron emission tomography (PET) markers of pathology in autosomal dominant AD. Methods: We analyzed baseline levels of plasma p-tau217 and its associations with amyloid PET, tau P

Type 2 diabetes (T2D) is a polygenic disease and studies to understand the etiology of the disease have required selectively bred animal models with polygenic background. In this review, we present two models; the Goto-Kakizaki (GK) rat and the Oikawa-Nagao Diabetes-Prone (ON-DP) and Diabetes-Resistant (ON-DR) mouse. The GK rat was developed by continuous selective breeding for glucose tolerance f

This paper investigates the impact of public policies aimed to foster entrepreneurship on the national entrepreneurial culture of a country. While most of the existing studies focus on the direct impact of policies on entrepreneurship outcomes, we propose that the impact of policies on entrepreneurial culture may be even more important for the development of economies in the long term. Using data

Systemic sclerosis, also known as scleroderma, is a rare and complex autoimmune connective-tissue disease. Once considered an untreatable and unpredictable condition, research advancements have improved our understanding of its disease pathogenesis and clinical phenotypes and expanded our treatment armamentarium. Early and accurate diagnosis is essential, while ongoing efforts to risk stratify pat

Ultra-scaled ferroelectrics are desirable for high-density nonvolatile memories and neuromorphic computing; however, for advanced applications, single domain dynamics and defect behavior need to be understood at scaled geometries. Here, we demonstrate the integration of a ferroelectric gate stack on a heterostructure tunnel field-effect transistor (TFET) with subthermionic operation. On the basis

This article discusses the issue of the right to health care for irregularised migrants in Sweden, from a human rights perspective. An extended right to health care for irregularised migrants came into effect through a legislative amendment in 2013. By exploring the legislative process before the new Act on Health Care to Some Foreigners Who Reside In Sweden Without the Necessary Permits in 2013,

I kapitlet diskuteras tre tolkningar av Arendt, tolkningar som alla har stöd i Arendts text men som vidareutvecklats på olika sätt av samhällsvetare och filosofer. I den första tolkningen är det bristen på tillgodoseende av mänskliga rättigheter för papperslösa om står i fokus. En viktig anledning till denna brist ligger i kopplingen mellan invandringsreglering och mänskliga rättigheter, att state

This article analyses sanctuary initiatives intended to change the situation of ‘irregularised residents’. Through fieldwork, three main activities are identified: assistance for welfare services, alternatives to inaccessible services, and inventing new ways of organising togetherness in the city. The role of activists in the initiatives links to discussions within Critical Human Rights literature

The article analyses the social constructions of rights as they come about through Swedish delegations preparing refugees for resettlement in Sweden, under the Cultural Orientation Programme (COP). COPs are analysed as an activity that manifests a need to convey rights. Fieldwork was conducted through video observations of COPs in Kenya and Sudan. Our empirical findings show how the Swedish offici

Asylkommissionen har bildats av forskare och personer med omfattande kunskap om migration och asylsökandes liv och villkor i Sverige, med syfte att initiera en granskning som utgår från asylsökandes levda erfarenheter och perspektiv. Bakgrunden till kommissionen är de återkommande rapporterna om en svår situation bland barn, unga och vuxna asylsökande, såsom oförutsägbara och inhumana beslut, ökanThe Asylum Commission has been formed by researchers and people with extensive knowledge of migration and asylum seekers’ living conditions in Sweden, with the aim of initiating enquiries based on asylum seekers’ lived experiences and perspec-tives.The background to the Commission is recurring reports of a difficult situation among children, adolescents and adult asylum seekers, such as unpredicta

This essay considers the relationship between education and hospitality, illustrated in a case that sparked a highly politicized debate on the topic. In 2012, several schools in Malmö, Sweden’s third largest city, excluded students from the regular process governing access to school as well as special support otherwise normally provided, based on the students’ unauthorized legal status. The contro

The politics of migration has become increasingly prominent as a site of struggle. However, the active subjecthood of people on the move in precarious situations is often overlooked. Irregular migration struggles raise questions about how to understand the agency of people who are marginalised. What does it mean to engage people produced as ‘irregular’ as active subjects of trans-border politics?

Although the 2023 Budget set the stage to finance a renewable-energy transition, ensuring that energy can be used as a tool to deliver environmental and socioeconomic well-being across all brackets of society requires multilevelgovernance and diverse actor networks. Some levers that all stakeholders – including investors – can use to embed justice in the financial architecture of renewable-energy

We report on an investigation into the nature of the experience that developers have with the spaces in which they work and live based on the reflections of the authors. We describe a few aspects of the structure of developers' experience around the malleability, ownership and control of the spaces and the emotions they induce, and consider what this may mean for future research.

Developers need to comprehend new code on a regular basis; a demanding task that gets complicated as projects grow in complexity and size. To help developers, documentation is typically added in the form of code comments, design documents, system documents, to name a few examples. Despite all these different kinds of documentation code base comprehension is still challenging and there is room for

OBJECTIVE: This study aimed to quantify the risk of COVID-19-related hospital admission in spouses living with partners in at-risk occupations in Denmark during 2020-21.METHODS: Within a registry-based cohort of all Danish employees (N=2 451 542), we identified cohabiting couples, in which at least one member (spouse) held a job that according to a job exposure matrix entailed low risk of occupati

Pelvic floor reconstructive surgery (PFRS) has suffered from high recurrence rates ever since its birth. Implants were thus quickly employed, initially autologous grafts and allografts. Technological development led to the manufacturing of synthetic implants that were believed to provide the support needed during urinary incontinence and pelvic organ prolapse (POP) surgery. However, due to a surge