Twin and family studies have established that there is a strong genetic basis for autism spectrum disorders. To facilitate the identification of susceptibility genes and to study pathways from gene-brain to cognition a more refined endophenotype-based approach may be useful. The purpose of the present study was to examine the neurocognitive endophenotype of autism, in families with multiple incide

Breast reconstruction is an everyday, apparently non-violent, even benevolent, remaking of the normal and the reasons for why reconstruction is motivated and legitimate are uncontroversial and widely accepted. In this article I will, through Donna Haraway’s way of conceptualizing discourses, analyze what I call “stories without significance”. I have mapped the stories and interpretations women und

There are a number of interpretations of the concept “integration” in Product Development (PD). Different sources tend to use different terminologies for describing the same phenomenon of integration, or use the same term for different purposes. This paper strives to capture the essence of the concept of “integration” within a product development project by looking for what is integrated and how i

Attention deficit hyperactivity disorder (ADHD) is the most prevalent neuropsychiatric disorder in the world. Currently, the diagnosis is based mainly on interviews, resulting in uncertainties in the clinical assessment. While some neuropsychological tests are used, their specificity and selectivity are low, and more reliable biomarkers are desirable. Previous research indicates that ADHD is assoc

CONTEXT: Perioperative oral carbohydrate intake is beneficial to general surgery patients. Total hip arthroplasty is a common surgical procedure, and even a moderate improvement in patient outcome could have a significant effect on the resources needed for these patients. However, few studies have focused on the effects of carbohydrate intake on orthopaedic patients. OBJECTIVE: The purpose of th

The associations between plant foods and breast cancer incidence are inconsistent. The objective of this study was to examine prospectively the association between dietary fibre, plant foods and breast cancer, especially the association between plant food intake and estrogen receptor (ER) alpha and beta defined breast cancer. Among women without prevalent cancer from the population-based prospecti

Circulating tumor cells (CTC) are shed in peripheral blood at advanced metastatic stages of solid cancers. Surface-marker-based detection of CTC predicts recurrence and survival in colorectal, breast, and prostate cancer. However, scarcity and variation in size, morphology, expression profile, and antigen exposure impairs reliable detection and characterization of CTC. We have developed a nonconta

Objective. To assess the accuracy and reproducibility of robot-assisted laparoscopic abdominal fertility sparing radical trachelectomy in women with early stage cervical cancer. Methods. Relevant prospective clinical data from 13 consecutive women planned for robotic radical trachelectomy between 2007 and 2012 were compared with retrospective data from 12 consecutive women planned for vaginal radi

Factor H (FH) binds apoptotic cells to limit the inflammatory potential of complement. Here we report that FH is actively internalized by apoptotic cells to enhance cathepsin L-mediated cleavage of endogenously expressed C3, which results in increased surface opsonization with iC3b. In addition, internalized FH forms complexes with nucleosomes, facilitates their phagocytosis by monocytes and induc

This paper presents a method for auto-tuning interactive ray tracing on GPUs using a hardware model. Getting full performance from modern GPUs is a challenging task. Workloads which require a guaranteed performance over several runs must select parameters for the worst performance of all runs. Our method uses an analyti- cal GPU performance model to predict the current frame’s render- ing time usi

This paper presents theory and algorithms for system identification suitable for the framework of behavioral system theory. An algorithm based on algebraic system theory and realization theory (Ho-Kalman realization) in a subspace model identification framework is presented. The novel approach considered consists of the formulation of input-output data as an impulse response model and the subseque

Background: Helicobacter pylori (H. pylori) uses various strategies that attenuate mucosal immunity to ensure its persistence in the stomach. We recently found evidence that H. pylori might modulate the natural killer group 2, member 2 (NKG2D) system. The NKG2D receptor and its ligands are a major activation system of natural killer and cytotoxic T cells, which are important for mucosal immunity a

Due to the high prevalence and great cardiovascular risks of hypertension, we need effective and evidence-based treatment strategies. Health-promoting one-way text messages could be a beneficial complement to antihypertensive drugs. However, this has yet to be proven in a primary healthcare setting. The purpose of this study was to investigate if health-promoting text messages could improve patien