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While necessary to protect human lives, many of the measures implemented by governments to contain the COVID-19 pandemic imposed significant costs on the population. Drawing on an original representative survey fielded during the first wave of COVID-19 in April–June 2020 in Sweden and Denmark, we examine how members of different occupational groups evaluated their government's pandemic strategies.
Pan Evaporation (Ep) plays a pivotal role in water resource management, particularly in arid and semi-arid regions. This study assesses the predictive performance of a comprehensive range of advanced machine learning (ML) and deep learning (DL) algorithms for Ep prediction using readily available environmental sensing data. The models investigated include M5 Prime (M5P), M5Rule (M5R), Kstar, as we
An incremental high-cycle fatigue damage model is combined with topology optimization to design structures subject to non-proportional loads. The optimization aims to minimize the mass under compliance and fatigue constraints. The fatigue model is based on the concept of an evolving endurance surface and a system of ordinary differential equations that model the local fatigue damage evolution. A r
Global warming has accelerated permafrost degradation, destabilizing soil organic carbon (SOC) in wetlands. Soil microorganisms play a crucial role in SOC decomposition. Despite increasing studies on soil microorganisms and their associated impacts on SOC decomposition in wetlands, few studies have simultaneously investigated the impacts of soil physical properties and nutrient stoichiometry on so
Flower-visiting insects and the plants that depend on them are declining due to habitat loss and deterioration. Road verges, which often provide abundant floral resources, are gaining attention for their potential conservation value, as they can support a high abundance and diversity of flower-visiting insects. Thereby, flower-abundant road verges may benefit pollination in surrounding landscapes.
Context: The mechanisms underlying bone fragility and increased fracture risk observed in individuals with type 2 diabetes (T2D) are not yet fully elucidated. Previous research has suggested a role for neuropeptides in regulating bone metabolism; however, the contribution of the neuropeptide Neurotensin (NT), which is thoroughly implicated in T2D and cardiovascular disease, has not been investigat
The millennial-scale hydroclimate variability in East Asia has been debated for a long time due to the lack of reliable precipitation records from southern China and inconsistent model simulations. Here, we reconstruct a 40-kyr rainfall record for southern China and Taiwan based on enviro-magnetic and clay mineral proxy parameters from a northern South China Sea marine sediment core. Both proxies
Progressive leptomeningeal metastases (LM) are associated with intractable neurological symptoms and a poor prognosis, and effective treatment options are limited. Intrathecal (IT) pemetrexed has been shown to confer clinical benefit in lung adenocarcinoma, yet our understanding of the efficacy and safety of the treatment is limited. We report a patient with a long-standing history of leptomeninge
Intratelencephalic neurons are a crucial class of cortical principal neurons that heavily innervate the striatum and cortical areas bilaterally. Their extensive cortico-cortical and cortico-striatal connectivity enables sensorimotor integration within the telencephalon, but their role in motor control remains poorly understood. Here, we used a chemogenetic approach to explore the role of intratele
Identifying potential moisture damage is crucial for maintenance practices and assurance of well-being of occupants. However, due to limited information availability and standardization, assessing damage prevalence on the building stock scale remains understudied. By combining investigation records and building databases, this study leverages data analytic techniques and machine learning modeling
The serine protease cathepsin G is synthesized during the promyelomonocytic stage of neutrophil and monocyte differentiation. After processing, including removal of an amino-terminal propeptide from the catalytically inactive proform, the active protease acquires a mature conformation and is stored in azurophil granules. To investigate the importance of the proform-conformation for targeting to gr
The Chicxulub asteroid that ended the Cretaceous Era ∼66.05 million years ago caused a prolonged time of global darkness – the impact winter – leading to mass extinctions. Elements from the asteroid, including the platinum group elements (PGEs) osmium, iridium and platinum are known from the globally distributed boundary clay but their carrier elements have so far been unknown. We identify, for th
We present new true triaxial compression data obtained in the ductile regime on Bleurswiller sandstone. The deformed samples show a range of failure modes qualitatively similar to what was reported by earlier experimental studies performed in conventional conditions (axisymmetric compression). In particular, visual inspection and X-ray Computed Tomography imaging reveal compaction localization in
This work presents a data-driven method for learning low-dimensional time-dependent physics-based surrogate models whose predictions are endowed with uncertainty estimates. We use the operator inference approach to model reduction that poses the problem of learning low-dimensional model terms as a regression of state space data and corresponding time derivatives by minimizing the residual of reduc
Attosecond science enables the study of ultrafast dynamics on atomic scales, providing fundamental insights into light–matter interaction. This thesis work aims to advance the development and application of an attosecond light source capable of delivering extreme ultraviolet (XUV) pulses with exceptionally high intensity.High-order harmonic generation (HHG) is a nonlinear process where a strong la
Notch wear often determines tool life when machining stainless steel. Chemical Vapour Deposited (CVD) Al2O3/Ti(C,N) coated cemented carbide tools are the first recommendation for turning of stainless steel. The CVD coating plays a vital role in reducing and delaying tool wear progress. Hence, it is essential to understand the interaction between the initiation of notch wear and the coating degrada
In stainless steel turning, cutting tool life is often limited by excessive localised damage at the depth of cut line, known as notch wear. Previous research revealed that notch wear in CVD (chemical vapour deposition) Al2O3/Ti(C,N) coated WC-Co tools begins as a coating brittle fracture already after 0.3 m of cutting. This paper investigates the impact of cutting tools and workpiece materials on
