Aims: The left atrial appendage (LAA) produces natriuretic peptides and its removal or occlusion might increase the risk of heart failure (HF). We aimed to investigate the incidence of HF after LAA occlusion or removal (LAAO) in the Left Atrial Appendage Occlusion Study (LAAOS III). Methods and results: Patients (n = 4811) with atrial fibrillation (AF) and a CHA2DS2-VASc score ≥2, who were having

Objective We investigated associations between bioaerosol exposures and work-shift changes in lung function and inflammatory markers among recycling workers. Methods Inhalable dust was measured with personal samplers and analyzed for endotoxin, bacteria, and fungi (incubated at 25 °C and 37 °C) levels. Lung function (FEV1, FVC) was measured before and after work-shifts and serum concentrations of

After the COVID-19 pandemic, during which teachers developed a lot of online course material, teachers worldwide are challenged with how to combine online teaching with classroom teaching in an efficient way. This paper presents Discussion seminars, a teaching activity that structures discussions clearly, making it easy for students and teachers to follow the discussion. The paper puts Discussion

Many governments worldwide have proposed transitioning from a fossil-based economy to a bioeconomy to address climate change, resource depletion, and other environmental concerns. The bioeconomy utilizes renewable biological resources across all sectors and is strongly founded on scientific advances and technological progress. Given that the bioeconomy spans multiple sectors, industries, and techn

Programme:Jörg Widmann Towards Paradise (Labyrinth VI)*Gustav Mahler Symphony No 5The trumpet concerto “Towards Paradise (Labyrinth VI)” was especially written for Håkan Hardenberger (21/22) by composer Jörg Widmann.

Extreme solar particle events (ESPEs) are infrequent yet highly potent manifestations of solar activity. These events result in the production of significant amounts of cosmogenic isotopes (CIs): 10Be, 36Cl, and 14C, which are subsequently deposited in natural stratified archives. Analyzing CI measurements from these archives allows us to assess the particle fluxes during ESPEs. In this study, we

Pulmonary veno-occlusive disease (PVOD) is a lethal variant of pulmonary hypertension. The degree of pulmonary arterial involvement varies. Here, we compare two PVOD patients who were transplanted at 8 years of age, whereof one is a homozygous EIF2AK4 mutation carrier. Tissue was imaged with synchrotron-based micro-CT and the results were compared with clinical data and sectioned tissue was analyz

The extent to which bullying victimization is associated with an increased risk of obsessive-compulsive disorder (OCD) has received little empirical attention. This longitudinal, population-based, genetically informative study examined whether self-reported bullying victimization at age 15 was associated with a clinical diagnosis of OCD in the Swedish National Patient Register and with self-report

Transverse momentum pT spectra and anisotropic flow distributions are studied for charmonia and charmed hadrons produced in Pb-Pb collisions and measured with the ALICE detector at the CERN Large Hadron Collider (LHC). The investigations are performed within the framework of the Statistical Hadronization Model with the transverse dynamics evaluated using predictions from relativistic viscous hydro

The Epithelial Science Expert Group convened on 18–19 October 2023, in Naples, Italy, to discuss the current understanding of the fundamental role of the airway epithelium in asthma and other respiratory diseases and to explore the future direction of patient care. This review summarises the key concepts and research questions that were raised. As an introduction to the epithelial era of research,

Aims: To estimate the proportion eligible for lipid-lowering therapy (LLT) when using the systemic coronary risk estimation 2 (SCORE2) on apparently healthy individuals. Methods and results: Individuals aged 50-64 years were randomly invited to The Swedish Cardiopulmonary Bioimage Study (n = 30 154). Participants with previous atherosclerotic cardiovascular disease (CVD), diabetes mellitus, or chr

We show that many-body interference phenomena are exponentially suppressed in the particle number, if the identical quantum objects brought to interference acquire a finite level of distinguishability through statistical mixing of some internal, unobserved degrees of freedom. We discuss consequences for cold atom and photonic circuitry experiments.

Background: There are differences in oesophageal cancer care across Sweden. According to national guidelines, all patients should be offered equal care, planned and administrated by regional multidisciplinary team meetings. The aim of the study was to investigate differences between regional multidisciplinary team meetings in Sweden regarding clinical staging and treatment recommendations for oeso

Hydraulic force, a novel mechanism shown to aid diastolic filling, can be calculated by assessing the geometrical relationship between the left ventricular and atrial short-axis areas (atrioventricular area difference, AVAD) (Maksuti E, Carlsson M, Arheden H, Kovács SJ, Broome M, Ugander M. Sci Rep 7: 43505-43510, 2017; Steding-Ehrenborg K, Hedstrom € E, Carlsson M, Maksuti E, Broome M, Ugander M,

Aims: Men are more likely to suffer a myocardial infarction than women, but population-based studies on sex differences in imaging-detected atherosclerosis are lacking. The aims were to assess sex differences in the prevalence of imaging-detected coronary and carotid atherosclerosis, as well as multivariable adjusted associations between sex and atherosclerosis. Methods and results: Participants a

Successful eradication or control of prevailing infectious diseases is linked to vaccine efficacy, stability, and distribution. The majority of protein-based vaccines are transported at fridge (2–8 °C) temperatures, cold chain, to retain potency. However, this has been shown to be problematic. Proteins are inherently susceptible to thermal fluctuations, occurring during transportation, causing the

Background: A large part of the Swedish population is exposed to higher levels of air pollution than the health-centered air quality guidelines recommended by the World Health Organization (WHO). Aim: The aim of the study was to illustrate the potential health benefits of cleaner air in Sweden by conducting a comprehensive health impact assessment, using a population sample of 100,000 individuals

Objective Assessing the histology-specific prognosis of epithelial ovarian cancer (OvCa) is clinically challenging, especially in a patient population with a favorable prognosis. This study investigated the histology-specific long-term oncologic outcomes in OvCa patients who underwent complete tumor resection using a large-scale patient cohort form multiple institutions under a central pathologica

The synthesis of large, freestanding, single-atom-thick two-dimensional (2D) metallic materials remains challenging due to the isotropic nature of metallic bonding. Here, we present a bottom-up approach for fabricating macroscopically large, nearly freestanding 2D gold (Au) monolayers, consisting of nanostructured patches. By forming Au monolayers on an Ir(111) substrate and embedding boron (B) at

Background: It is important to identify and evaluate cardiovascular risk factors at an early stage to address them accordingly. Among the younger population, the metabolic syndrome is less common than in older ages. However, each separate metabolic risk factor still has an additive effect on cardiovascular risk factor burden. Non-metabolic risk factors that occur in the younger population include