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Elevated plasma tyrosine kinases VEGF-D and HER4 in heart failure patients decrease after heart transplantation in association with improved haemodynamics

Receptor tyrosine kinases (RTKs) are implicated in cardiovascular growth and remodelling. We aimed to identify the plasma levels of RTKs and related proteins and their association with haemodynamic alterations in heart failure (HF) and related pulmonary hypertension (PH) following heart transplantation (HT). Using proximity extension assay, 28 RTKs and related proteins were analysed in plasma from

Master protocols in clinical trials : a universal Swiss Army knife?

Master protocols combine several sub-trials, each with their own research objectives, which is usually presented as one single clinical trial application. Master protocols have become increasingly popular in oncology and haematology, as either basket, umbrella, or platform trials. Although master protocols are intended to accelerate drug development and to reduce futility, their use poses challeng

Interfacial properties and interaction between beer wort protein fractions and isohumulone

It is well known that both protein and iso-humulone, originating from barley malt and hops respectively, play important roles in beer foam stability. In this study, we hypothesize that the interaction of iso-humulone and different beer proteins will give rise to adsorbed layers with different characteristics at hydrophobic surfaces. The properties of these adsorbed layers are likely to play a cruc

A simple wavelet-based test for serial correlation in panel data models

Hong and Kao (2004) proposed a class of general applicable wavelet-based tests for serial correlation of unknown form in the residuals from a panel regression model. The tests can be applied to both static and dynamic panel models. Their test, however, is computationally difficult to implement, and simulation studies show that the test has poor small-sample properties. In this paper, we extend GenHong and Kao (2004) proposed a class of general applicable wavelet-based tests for serial correlation of unknown form in the residuals from a panel regression model. The tests can be applied to both static and dynamic panel models. Their test, however, is computationally difficult to implement, and simulation studies show that the test has poor small-sample properties. In this paper, we extend Gen

Limiting conditions for a sustained flame over condensed fuels : Analysis by experiments and stagnant layer theory

Ignition and extinction characteristics of a material determine whether a fire will be initiated and grow. In fire safety engineering, where modellers deal with a multitude of materials, simplified thresholds are commonly used to determine when ignition and extinction occur.Such a threshold is the critical mass flux, which describes when sufficient fuel vapour is produced to support sustained flam