Exploring Regioselective 5N-acylation of Neuraminic acid
In this project, a regioselective method to deprotect and acylate the amide on C5 of sialic acid is explored. Sialic acid is one of the most complex monosaccharides and is an important ligand in many higher organisms in intercellular cell communication. The most prominent example is related to the immune system. Sialic acids are attached as the terminal carbohydrate on cell surface glycans, which
