Genome-wide association studies have shown that variation in MTNR1B (melatonin receptor 1B) is associated with insulin and glucose concentrations. Here we show that the risk genotype of this SNP predicts future type 2 diabetes (T2D) in two large prospective studies. Specifically, the risk genotype was associated with impairment of early insulin response to both oral and intravenous glucose and wit

Rätten att röra sig fritt, inom och över nationsgränser, är ett ideal intimt förknippat med det moderna samhällets självförståelse. Att man kan bryta upp från en plats för att söka en annan, tillfällig eller permanent, vistelseort är en central del av vårt samhälles demokratiuppfattning. I synnerhet i dag är det påfallande hur starkt detta ideal framhävs. Berlinmurens fall och globaliseringen av a

Fibroblast growth factor (FGF) signaling controls axis formation during endoderm development. Studies in lower vertebrates have demonstrated that FGF2 primarily patterns the ventral foregut endoderm into liver and lung, whereas FGF4 exhibits broad anterior-posterior and left-right patterning activities. Furthermore, an inductive role of FGF2 during dorsal pancreas formation has been shown. However

Nicotinamide adenine dinucleotide phosphate (NADPH) enhances Ca(2+)-induced exocytosis in pancreatic beta-cells, an effect suggested to involve the cytosolic redox protein glutaredoxin-1 (GRX-1). We here detail the role of GRX-1 in NADPH-stimulated beta-cell exocytosis and glucose-stimulated insulin secretion. Silencing of GRX-1 by RNA interference reduced glucose-stimulated insulin secretion in b

Not available.

OBJECTIVES: Alzheimer disease (AD) can now be diagnosed in subjects with mild cognitive impairment (MCI) using biomarkers. However, little is known about the rate of decline in those subjects. In this cohort study, we aimed to assess the conversion rate to dementia and identify prognostic markers in subjects with MCI and evidence of amyloid pathology. METHODS: We pooled subjects from the VU Un

Qualitative methods are well established in music education research. This has led to an interesting body of research, each project investigating in depth a specific situation or phenomenon. One way of combining the advantages of qualitative studies with the aim of acquiring general theories Of music education might be to develop methods of re-analyzing primary studies on a secondary, meta level.

This thesis deals with the problem of estimating a function or one of its derivatives from a set of measurements, mainly of a bivariate or spatial nature which is so common in environmental applications. In this work particular attention has been on the lidar (light detection and ranging) application which is a versatile technique for measurement of among other things atmospheric trace gases. In l

Abstract in UndeterminedContextThe key for effective problem prevention is detecting the causes of a problem that has occurred. Root cause analysis (RCA) is a structured investigation of the problem to identify which underlying causes need to be fixed. The RCA method consists of three steps: target problem detection, root cause detection, and corrective action innovation. Its results can help with

Specialutvecklad elektronik för rehabilitering avhjärnskadade är tidsödande och dyrbar att utveckla. Björn Breidegard från Certec, Lunds tekniska högskola, berättar här hur man i stället kan använda enbillig TV-kamera i kombination med dator och programvara. Resultaten är mycket lyckade.