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Objective: To investigate whether modifying hearing aid gain at the individual’s tinnitus pitch augments tinnitus mitigation from hearing aid amplification. Design: Participants were randomised to receive hearing aids delivering either objectively verified Conventional Amplification (n = 36), Increased Gain at Tinnitus Pitch (n = 36), or eliminated gain at tinnitus pitch, so-called Notch Therapy (
The number of degrees of freedom (NDoF) in a communication channel fundamentally limits the number of independent spatial modes available for transmitting and receiving information. Although the NDoF can be computed numerically for specific configurations using singular value decomposition (SVD) of the channel operator, this approach provides limited physical insight. In this paper, we introduce a
Aim: Periodontitis proxy variables enable an expansion of periodontal research. The study aimed to estimate the validity of questionnaire items and registry data in relation to Stage III–IV periodontitis and having 50% bone loss. Methods: Malmö Offspring Dental Study (MODS) participants (995) filled out questionnaires and underwent periodontal and panoramic radiography examinations. The questionna
Purpose: Accurate non-invasive prediction of histopathologic invasiveness and recurrence risk remains a clinical challenge in resectable non-small cell lung cancer (NSCLC). We developed and validated the Edge Proximity Score (EPS), a novel [18F]FDG PET/CT-based spatial imaging feature that quantifies the displacement of SUVmax relative to the tumor centroid and perimeter, to assess tumor aggressiv
Expands the scope of Islamic Studies to include the study of non-Muslim Islam Introduces a new concept (non-Muslim Islam) that challenges commonly held notions about the object of study within Islamic studies Invites critical thinking about how knowledge about Islam is produced in non-Muslim majority societies on both a scholarly and societal level This book empirically substantiates a re-conceptu
Prurigo nodularis (PN) is a chronic, itchy, inflammatory skin condition that negatively affects quality of life. A study was undertaken to investigate the healthcare utilization, including treatment patterns and direct costs for specialist care, for PN in Sweden. Linkage cohorts were created from national Swedish patient and prescription registers, and the cost-per-patient database of PN adults in
Background: Rare disease clinical trials are notorious for complexities that frequently result in study-start delays. However, there is limited knowledge about how participants and researchers perceive these delays and what factors shape their experiences. A clinical trial in the rare, progressive disorder Pantothenate Kinase-Associated Neurodegeneration—the PKAN trial—encountered an unexpected de
Movement disorders are common in inherited metabolic diseases (IMDs) and significantly impact quality of life. Unfortunately, they are often underrecognised by metabolic physicians. This study investigated whether a new screening tool improves recognition of movement disorders in IMD patients by non-neurologists. Internists and paediatricians specialized in IMDs assessed videos of 44 IMD patients
Background and objective: Prostate cancer (PC) is the second most common cancer and a leading cause of death among males. In this systematic review we evaluated cohort studies and randomized controlled trials (RCTs) on the relationship between dietary patterns and PC risk, progression, mortality, and biomarkers. Methods: A systematic search of MEDLINE, Embase, and Cochrane Central was conducted th
Background: We set out to profile the immune mechanisms active in treatment-naïve oligoarticular JIA (oJIA) to improve the knowledge of its immunopathogenesis, to identify potential biomarkers that can aid diagnosis, predictions and that correlate with clinical disease parameters. Methods: Using Olink proteomics (inflammation panel measuring 92 markers), we defined and compared the inflammation pr
This study examines the impact of grammatical gender on memory recall among simultaneous bilinguals with two three-gendered languages (Ukrainian and Russian). Ukrainian-Russian bilinguals and English monolingual controls were tested on their ability to remember names assigned to objects with either matching or mismatching grammatical genders across their two languages. Results showed that bilingua
The recognized importance of systemic and dynamic perspectives on both AI and innovation management calls for the retheorization to support the AI technology adoption in innovation management. As extant knowledge about a systems approach to realize dynamic roles of both augmentation and automation of AI-human collaboration in innovation management is limited, this study aims to explore how to leve
This chapter explores the evolution and effectiveness of Sweden's climate policy mix for decarbonizing the transport sector—a major contributor to national greenhouse gas (GHG) emissions. Despite early leadership in climate policy, Sweden faces challenges in aligning policy implementation with ambitious goals, such as a 70 % reduction in transport emissions by 2030. The chapter shows that Sweden's
Recent droughts from 2017 to 2020 induced significant stress on woodland canopies across eastern Australia, resulting in widespread tree browning and mortality. However, the trajectory of post-drought recovery remains unclear, with uncertainty about whether canopy conditions are improving or continuing to decline. Identifying the key local environmental and climatic factors influencing drought-ind
Many species are currently experiencing range shifts in response to changing environmental conditions with potentially serious genetic consequences. Repeated founder events and strong genetic drift are expected to erode genetic variation at the range front, reducing adaptive potential and slowing or even halting the expansion. However, the severity of these consequences for common and highly mobil
Polyamines are regulatory metabolites with key roles in transcription, translation, cell signalling and autophagy1. They are implicated in multiple neurological disorders, including stroke, epilepsy and neurodegeneration, and can regulate neuronal excitability through interactions with ion channels2. Polyamines have been linked to pain, showing altered levels in human persistent pain states and mo
Unlike glucose, the sub-optimal xylose utilization in recombinant Saccharomyces cerevisiae strains may stem from an unusual signaling response that is not adapted to detecting xylose as a fermentable substrate. We hypothesize that the membrane receptor Snf3p, known for sensing extracellular low glucose levels, may contribute to xylose recognition. To test this, we explored the effect of SNF3 inact
