Bacterial exotoxins with ADP-ribosyltransferase activity can be divided into distinct clades based on their domain organization. Exotoxins from several clades are known to modify actin at Arg177; but of the 14-3-3 dependent exotoxins only Aeromonas salmonicida exoenzyme T (AexT) has been reported to ADP-ribosylate actin. Given the extensive similarity among the 14-3-3 dependent exotoxins, we initi

Do personality traits in highly intelligent individuals relate to their work engagement? Seemingly little is known about the relationship between personality and work engagement for gifted individuals. In what may be the first study to do so, a Swedish Mensa sample (n = 353) was explored with a two-part aim: to assess psychometric personality properties and to investigate the relationship between

In his late writings Husserl emphasizes how the semiotic properties of writing, and of mathematical formulae and diagrams, are crucial for the historical, cross-generational survivability of meaning and specifically indispensable to the operation of scientific knowledge. However, the demand for objectivity, exactitude, and repeatability insidiously interferes with the meaning that such signs seek

This article analyzes how Hindu nationalists employ fantasy narratives to counteract resistance, with a particular focus on narratives of ‘motherhood’ and ‘pseudoscience’. It does so by first introducing a conceptual discussion of the relationship between fantasy narratives, ontological insecurity, gender, and anti-science as a more general interrelationship characterizing pre- and post-COVID-19 f

DNA-encoded chemical libraries (DECLs) interrogate the interactions of a target of interest with vast numbers of molecules. DECLs hence provide abundant information about the chemical ligand space for therapeutic targets, and there is considerable interest in methods for exploiting DECL screening data to predict novel ligands. Here we introduce one such approach and demonstrate its feasibility

Neurodegenerative disorders are common and heterogeneous in terms of their symptoms and cellular affectation, making their study complicated due to the lack of proper animal models that fully mimic human diseases and the poor availability of post-mortem human brain tissue. Adult human nervous tissue culture offers the possibility to study different aspects of neurological disorders. Molecular, cel

Analyzing the deformation of liquid surfaces to better understand, for example, wave generation in oceanology or the formation of industrial spray systems, requires a series of three-dimensional snapshots that temporally resolve such events. This requirement is challenging, especially when applied to transient liquid surfaces that deform rapidly. A technique called Fringe Projection-Laser Induced

Demand-responsive control of electrically heated hot water storage tanks (HWSTs) is one solution, already present in the building stock, to stabilise volatile energy networks and markets. This has been put into sharp focus with the current energy crisis in Europe due to reduced access to natural gas. Furthermore, increasing proportions of intermittent renewable energy will likely add to this volat

Urban heat sources from urban infrastructure and buildings could meet ~10% of the European building heating demand. There is, however, limited information on how to use them. The EU project ReUseHeat has generated much of the existing knowledge on urban waste heat recovery implementation. Heat recovery from a data center, hospital and from water were demonstrated. Additionally, the project generat

Precision nutrition is an emerging concept that aims to develop nutrition recommendations tailored to different people's circumstances and biological characteristics. Responses to dietary change and the resulting health outcomes from consuming different diets may vary significantly between people based on interactions between their genetic backgrounds, physiology, microbiome, underlying health sta

OBJECTIVES: To describe clinical characteristics and prognosis related to heart failure (HF) phenotypes in a community-based population by applying a novel algorithm to obtain ejection fractions (EF) from electronic medical records. DESIGN: Retrospective population-based cohort study. SETTING: Data were collected for all patients with HF in Southwest Sweden. The region consists of three acute care

The rewriting of hagiographical texts was a common activity in Byzantium. From at least the ninth century until the end of the Byzantine era, ecclesiastical and non-ecclesiastical writers turned repeatedly to this form of writing, in some cases evidencing an astonishingly prolific textual output. Metaphrasis is the only word found in Byzantine titles to indicate a rewritten text but never used to

Cancers require telomere maintenance mechanisms for unlimited replicative potential. They achieve this through TERT activation or alternative telomere lengthening associated with ATRX or DAXX loss. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, we dissect whole-genome sequencing data of over 2500 matched tumor-control samples from 36 different tumor types a

Metaphrasis: A Byzantine Concept of Rewriting and Its Hagiographical Products represents a first and authoritative discussion of rewriting in Byzantium. It brings together a rich variety of articles that treat the topic of hagiographical rewriting from various angles.The contributors discuss and comment on different kinds of texts in Greek and other languages, including Apophthegmata Patrum, Passi

The discovery of driver mutations is one of the key motivations for cancer genome sequencing. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2658 cancers across 38 tumour types, we describe DriverPower, a software package that uses mutational burden and functional impact evidence to identify driver mutation

Focusing on how museums prioritize and produce content, Hip Heritage demonstrates how economic issues play an ever-larger role in determining how cultural heritage is being framed and presented in contemporary heritage museums. Drawing on ethnographic fieldwork conducted by the authors at seven museums over the course of five years, this book offers an in-depth analysis of heritage museums in Nord

Texts–and the stories and teachings they contained–travelled far along the Silk Road in the hands of merchants, missionaries, monastic communities and many more. The intricate itineraries and the many languages and scripts used on the way have received much attention, and we can therefore follow some of the stages and versions that stories like the Barlaam and Josaphat (as it was known in the West

Many primary tumours have low levels of molecular oxygen (hypoxia), and hypoxic tumours respond poorly to therapy. Pan-cancer molecular hallmarks of tumour hypoxia remain poorly understood, with limited comprehension of its associations with specific mutational processes, non-coding driver genes and evolutionary features. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG)

The impact of somatic structural variants (SVs) on gene expression in cancer is largely unknown. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole-genome sequencing data and RNA sequencing from a common set of 1220 cancer cases, we report hundreds of genes for which the presence within 100 kb of an SV breakpoint associates with altered e