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Background: The recently launched high-throughput assays for detecting antibodies against SARS-CoV-2 has contributed to the managing strategies for the COVID-19 pandemic. This study aimed to investigate the performance of three high-throughput assays and one rapid lateral flow test relative to regulatory authorities' recommended criteria. Methods: A total of 315 samples, including 150 pre-pandemic

Objectives: Spectrophotometric absorption curve analysis of cerebrospinal fluid (CSF) for oxyhaemoglobin and bilirubin is necessary to accurately diagnose subarachnoid haemorrhage (SAH) in patients with typical symptoms but with negative findings on X-ray examinations. In this study, we evaluated the performance of two methods for interpreting absorption curves; one method from the United Kingdom

This study aimed to describe differences in prevalence and the long-term presence of nucleocapsid antibodies (N-antibodies) elicited by SARS-CoV-2 infection in a Swedish blood donor population not subjected to lockdown. We tested 20,651 blood donor samples for nucleocapsid antibodies from the beginning of March 2020 and 27 months onwards using the Roche Elecsys Anti-SARS-CoV-2 assay. The proportio

Denna avhandling undersöker hur subtila former av medborgerligt motstånd tar form i Hongkongs pågående autokratisering. I en kontext präglad av vilande sociala rörelser, ökande mediecensur och digital övervakning visar studien att uttryck som inte aktivt söker uppmärksamhet ändå kan spela en viktig roll i medborgerligt engagemang. Med utgångspunkt i Hongkong efter införandet av den nationella säkThis thesis challenges the assumption that expressions that do not actively seek attention is less significant in the research of civic engagement, by foregrounding the arts of subtle resistance in contexts of social movement abeyance, heightened media censorship and digital surveillance. Drawing upon the empirical case of Hong Kong, where a National Security Law was enacted in 2020 to discourage

Background Exertional breathlessness is a limiting symptom that often coexists with anxiety and depression. We tested the hypothesis that anxiety and depression negatively impact exertional breathlessness in daily life and during standardised cardiopulmonary exercise testing (CPET). Methods Analysis of people aged ⩾40 years undergoing incremental cycle CPET. Exertional breathlessness in daily life

Background: Escalating resistance among Gram-negative pathogens limits β-lactam options. Cefepime/enmetazobactam combines a fourth-generation cephalosporin with a class A β-lactamase inhibitor. We evaluated its activity against multidrug, extensive and pandrug-resistant war-wound isolates from Ukraine.Materials and methods: We tested 215 clinical samples (2022-2023) isolated from wounded patients

Transcription factor (TF) proteins regulate gene activity by binding to regulatory regions, most importantly at gene promoters. Many genes have alternative promoters (APs) bound by distinct TFs. The role of differential TF activity at APs during tumour development is poorly understood. Here we show, using deep RNA sequencing in 274 biopsies of benign prostate tissue, localized prostate tumours and

Abstrasct Entrepreneurial ecosystems as lenses promoting innovation and entrepreneurship have attracted substantial interest in research. However attention towards the role of sector-specific actors, such as healthcare-related organizations, within entrepreneurial ecosystems remains underexplored. This paper investigates how healthcare-related organizations are conceptualized within entrepreneuria

The impact of variations in the three-dimensional structure of the genome has been recognized, but solid cancer tissue studies are limited. Here, we performed integrated deep Hi-C sequencing with matched whole-genome sequencing, whole-genome bisulfite sequencing, 5-hydroxymethylcytosine (5hmC) sequencing and RNA sequencing across a cohort of 80 biopsy samples from patients with metastatic castrati

In primary Sjögren's disease (pSjD), there is a well-documented increased risk of hematological malignancies, particularly lymphomas, whereas studies examining the incidence of solid tumors have often yielded conflicting results. Data concerning the incidence of breast and gynecological cancers are similarly inconsistent. The aim of this study was to further investigate the incidence of these so-c

BACKGROUND: Prostate cancer is a heterogenous disease, but once it becomes metastatic it eventually becomes treatment resistant. One mechanism of resistance to AR-targeting therapy is lineage plasticity, where the tumor undergoes a transformation to an AR-indifferent phenotype, most studied in the context of neuroendocrine prostate cancer (NEPC). However, activation of additional de- or trans-diff

This thesis explores the goal conflicts and trade-offs that editors in the Canadian federal public service navigate as they work to ensure that government communications products meet the objectives of the Policy on Communications and Federal Identity. The research design, which is interpretivist in approach, draws on document analysis, analytic autoethnography, and phenomenological hermeneutics t

Denna uppsats undersöker hur dionysiskt vansinne, med utgångspunkt i det Nietzscheanska apolloniska-dionysiska, gestaltas i Den hemliga historien. Uppsatsen analyserar även hur Backanterna, såväl explicit som implicit, fungerar som en intertext i Tartts roman och hur pjäsen påverkar romanens händelseutveckling.

Documented performance featuring spherical amplification.PHACE Series 2023/24 #1Wiener Konzertsaal, Berio-Saal, Wien (AT)Ensemble Phace09/01/2024From the program:Romitelli, Fausto (1963-2004, IT) – Professor Bad Trip (for ensemble and electronics) [1998-2000]

För otränade öron och ögon är det inte lätt att se vad operasång och attofysik har med varandra att göra. I det här bidraget visar dock Johan Mauritsson och Hedvig Jalhed att det finns påtagliga paralleller. Artikeln är en frukt av ett populärvetenskapligt projekt där artikelförfattarna använder just dessa beröringspunkter för att sprida såväl visdom som skönhet för både öron och ögon.

The operation of instruments and detectors in laboratory or beamline environments presents a complex challenge, requiring stable operation of multiple concurrent devices, often controlled by separate hardware and software solutions. These environments frequently undergo modifications, such as the inclusion of different auxiliary devices depending on the experiment or facility, adding further compl