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An elderly, right-handed, male patient presented to the emergency department at a middle sized hospital with a few hours' history of mild confusion and a difficulty expressing himself verbally. Past medical history consisted of hypertension and cured hairy cell leukemia. CT scan of the brain showed a 5 cm infarction in the left occipital lobe, and a corresponding P2 occlusion was seen. The patient
I dagens samhälle kan människor med sårbarhetsfaktorer, såsom ålderdom eller respiratoriska sjukdomar, riskera att dö när de utsätts för virusinfektioner. Det figurerar ständigt olika influensavarianter bland oss som vissa kan tillfriskna från utan några mediciner, men de individer som har en uttalade sårbarhet behöver antivirala läkemedel för att bekämpa viruset. Ett av dessa läkemedel är ZanamivIn this study, a novel route to synthesising Zanamivir have been accomplished. In the past two decades, many scientists have struggled to find a green and step-economical route to synthesising Zanamivir. None have succeeded to insert guanidine; thus, relying on amination and reduction with explosive azido reagents, causing the synthesis to be far too long and hazardous. Our aim was to shorten the
In manufacturing, thermomechanical processes such as static annealing and hot working are commonly used to tailor the microstructure of metals to achieve favourable macroscopic material properties that meet specific application requirements. To improve sequential manufacturing processes and to accurately predict the microstructural changes of the material along the process chain, physically motiva
The solution of coupled multi-field problems by means of commercially available finite element codes such as Abaqus constitutes an important part in the study of industrial processes. Against this background, a comprehensive implementation framework for a gradient-enhanced continuum damage formulation in a thermo-mechanically coupled finite deformation setting is proposed in this contribution. To
Professional Emotions in Court examines the paramount role of emotions in the legal professions and in the functioning of the democratic judicial system. Based on extensive interview and observation data in Sweden, the authors highlight the silenced background emotions and the tacitly habituated emotion management in the daily work at courts and prosecution offices. Following participants ‘backstaProfessional Emotions in Court examines the paramount role of emotions in the legal professions and in the functioning of the democratic judicial system. Based on extensive interview and observation data in Sweden, the authors highlight the silenced background emotions and the tacitly habituated emotion management in the daily work at courts and prosecution offices. Following participants ‘backsta
The free and open source software tool ADAPT (A Diversely Applicable Parameter Identification Tool) for the inverse parameter identification of constitutive material models is presented and applied in combination with Finite Element (FE) simulations. Different types of input data, namely integral data such as forces and field data such as displacement and strain fields, are considered within a mul
How travellers perceive the quality of public transport services has profound influence on their satisfaction and thus of their inclination to choose this mode of transport. Punctuality, which may be interpreted as timetable adherence or overall travel time predictability, is often pointed out as the most important constituent of overall service reliability of public transport systems. However, in
The railway transport system has seen an increasing demand in recent years, while delays and missed punctuality goals continue to be problems in many countries. To improve punctuality, the amount of primary delays needs to be decreased, and knowledge of the shares of the different types of delay – entry, run, and dwell – is important to identify the most efficient countermeasures. This paper inves
The timing of the spring season in the boreal region is shifting under global warming, with profound impacts on ecosystems and hydrological processes. However, the mechanisms driving this transition and its considerable interannual variability are not well described, especially regarding the influence of large-scale atmospheric teleconnection patterns. This study examines the temporal variability
This study examines the long-term socioeconomic impacts of 44 train station openings between 1995 and 2015 across Swedish regions. Using the conditional difference-in-differences estimator developed by Callaway and Sant'Anna (2021), which accounts for variation in treatment effects across time and locations, we evaluate the impact on population, income, education, and unemployment. Twenty years af
This chapter explores performances of emotion regulation through a dramaturgical lens, focusing on occupations with high performative demands. While reviewing research and theorizing on performance, we point to key intersections between sociological studies on emotion management and psychological studies on emotion regulation. First, we focus on the scaffolding of performance, how the script and t
Access is the process of establishing rapport with a field containing different phases without an articulated end. Qualitative research often involves studying people in their social setting, documenting action, and meaning making in relation to the field in which it occurs through ethnographic methods such as observations, shadowing, and interviews. Gaining permission to a site or a specific grou
Data-driven methods provide great potential for future applications in engineering, for example in terms of more efficient simulations. Conventional material models and the associated constitutive equations are substituted by a minimization of a distance between so-called material and mechanical states, which, however, leads to non-unique solutions. The aim of this paper is to analyze the influenc
This chapter analyses humour from an emotion sociological perspective, linking humour to power, status, and group solidarity. It draws from about 300 observed trials and interviews with 43 judges and 41 prosecutors from four Swedish districts courts. Humour is sometimes skilfully used as a strategy to ease tension, relieve boredom or to reprimand. It is initiated/allowed by the judge, but high-staThis chapter analyses humour from an emotion sociological perspective, linking humour to power, status, and group solidarity. It draws from about 300 observed trials and interviews with 43 judges and 41 prosecutors from four Swedish districts courts. Humour is sometimes skilfully used as a strategy to ease tension, relieve boredom or to reprimand. It is initiated/allowed by the judge, but high-sta
Understanding damage mechanisms and quantifying damage is important in order to optimise structures and to increase their reliability. To achieve this goal, experimental- and simulation-based techniques are to be combined. Different methods exist for the analysis of damage phenomena such as fracture mechanics, phase field models, cohesive zone formulations and continuum damage modelling. Assuming
Bakgrund: Ett mått på följsamhet till paleolitisk kost som inte baseras på populationsrelativa intag av livsmedelsgrupper har hittills saknats. Syftet med denna avhandling var att utvärdera användbarheten av Paleolithic Diet Fraction (PDF), ett nytt mått på följsamhet till paleolitisk kost, beräknat som andelen av det totala intaget av livsmedelsgrupper som utgörs av paleolitiska livsmedelsgrupperAbstract: Background: A measure of adherence to the Paleolithic diet not based on population-relative food group intakes was lacking. The aim of this thesis was to evaluate the usefulness of the Paleolithic Diet Fraction (PDF), a novel measure of adherence to the Paleolithic diet, calculated as the fraction of total food group intake derived from Paleolithic food groups. Methods: PDF was calculate
Background and aimMany patients with depressive disorders do not improve with first-line treatment with selective serotonin inhibitors (SSRIs). Adverse drug reactions (ADRs) are common. However, there are no reliable methods to predict treatment response.The general aim of this thesis was to investigate the role of peripheral serotonin and the polymorphic CYP2D6 gene as potential biomarkers of tre
