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The ubiquitin kinase-ligase pair PINK1-PRKN recognizes and transiently labels damaged mitochondria with ubiquitin phosphorylated at Ser65 (p-S65-Ub) to mediate their selective degradation (mitophagy). Complete loss of PINK1 or PRKN function unequivocally leads to early-onset Parkinson disease, but it is debated whether impairments in mitophagy contribute to disease later in life. While the pathway
We consider the multivariate moment generating function of the disk counting statistics of a model Mittag-Leffler ensemble in the presence of a hard wall. Let n be the number of points. We focus on two regimes: (a) the “hard edge regime” where all disk boundaries are at a distance of order n1 from the hard wall, and (b) the “semi-hard edge regime” where all disk boundaries are at a distance of ord
Ecological intensification has been embraced with great interest by the academic sector but is still rarely taken up by farmers because monitoring the state of different ecological functions is not straightforward. Modelling tools can represent a more accessible alternative of measuring ecological functions, which could help promote their use amongst farmers and other decision-makers. In the case
We propose to use quantum information notions to characterize thermally induced melting of nonperturbative bound states at high temperatures. We apply tensor networks to investigate this idea in static and dynamical settings within the Ising quantum field theory, where bound states are confined fermion pairs - mesons. An equilibrium signature of meson melting is identified in the temperature depen
Cancer is a life-threatening disease worldwide. Nanomedicine and nanodelivery systems are recently developed scientific field that employs specific materials in the nanoscale range to deliver drugs. Lipid-based nanoparticles are an ideal delivery system since they exhibit many advantages, including high bioavailability, self-assembly, formulation simplicity, and the ability to exhibit a plethora o
Let T be an n× n truncation of an (n+ α) × (n+ α) Haar distributed unitary matrix. We consider the disk counting statistics of the eigenvalues of T. We prove that as n→ + ∞ with α fixed, the associated moment generating function enjoys asymptotics of the form exp(C1n+C2+o(1)), where the constants C1 and C2 are given in terms of the incomplete Gamma function. Our proof uses the uniform asymptotics
Public-domain availability for bioinformatics software resources is a key requirement that ensures long-term permanence and methodological reproducibility for research and development across the life sciences. These issues are particularly critical for widely used, efficient, and well-proven methods, especially those developed in research settings that often face funding discontinuities. We re-lau
Aims Invariant natural killer T (iNKT) cells, a T cell subset that is CD1d-restricted and expresses a semi-invariant T cell receptor, have been proposed to contribute to dyslipidaemia-driven cardiovascular disease due to their ability to specifically recognize lipid antigens. Studies in mice have attributed pro-atherogenic properties to iNKT cells, but studies in humans investigating associations
In the cuprate superconductors, the spatial coherence of the charge density wave (CDW) state grows below a temperature TCDW, the origin of which is debated. Using x-ray photon correlation spectroscopy, we have studied the temporal atomic relaxation dynamics in La1.88Sr0.12CuO4 to shed light on this question. Cooling within an emergent structurally distorted phase, which favors the CDW modulation i
Searches for new physics (NP) at particle colliders typically involve multivariate analysis of kinematic distributions of final state particles produced in a decay of a hypothetical NP resonance. Since the pair-production cross-sections mediated by such resonances are strongly suppressed by the NP scale, this analysis becomes less relevant for NP searches for masses of the BSM resonance above 1 Te
This article analyses infant and child sex ratios in late Imperial Russia relying on district-level information obtained from the 1897 Russian census (489 districts). The article shows that child sex ratios were, on average, relatively low (around 98 boys per hundred girls) due to the biological female advantage: the extremely high infant and child mortality rates took a greater toll on boys and p
This paper examines the economic effects of German settlers on Imperial Russia’s transition to advanced industrialization in the late nineteenth and early twentieth century. Between 1763 and 1860, thousands of German migrants came to the country’s frontier regions, drawn by a state-sponsored settlement policy. Using accidental elements in German migration induced by policy, the paper demonstrates
Cultural norms play a pivotal role in shaping how societies respond to crises. This study examines the causal effect of ethnic-specific gender norms on gender-biased mortality during resource shocks. Studying the 1891-1892 Russian famine, we compare cohorts born before and after the famine in districts differentially affected by the famine and with diverse gender norms. Our findings reveal that ar
The thesis focuses on studying dense particle flows, which are either dry or submerged in a Newtonian fluid through two dimensional numerical simulations using the discrete element method (DEM). The First paper deals with dense suspensions in viscous regime under oscillatory planar shear. We found that having an oscillatory shear can help reducing the viscosity of the suspension. Also, in the fric
This article examines the way the notion of labour regime in artisanal and small-scale mining (ASM) research can contribute to new ways of conceptualising this sector's challenges. It starts by reviewing how the phenomenal expansion of ASM over the last decades has been problematised, and highlights the need to better understand what drives artisanal miners to operate under extremely precarious wo
Articles 184 and 185 of the VAT Directive provide for the general obligation to adjust an initial deduction if it is higher or lower than that to which the taxable person was entitled. Does the abandonment of an investment project always imply the obligation to adjust deductions in respect of the acquired goods and/or services that cannot be used in the taxed activity of the taxable person? What i
High levels of ADAM17 activity have emerged as an important mediator in severe COVID-19. This study aims to characterize eventual causal relationships between ADAM17 and COVID-19. Using Mendelian randomization analyses, we examined the causal effects of circulating ADAM17 on COVID-19 outcomes using summary statistics from large, genome-wide association studies of ADAM17 (up to 35,559 individuals)
