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Diabetes mellitus (DM) is the most severe metabolic disease that reached the level of a global pandemic and is associated with high cardiovascular morbidity. Statins are the first-line lipid- lowering therapy in diabetic patients with or without a history of atherosclerotic disease. Although well tolerated, chronic treatment may result in side effects that lead to treatment interruption. Mitochond
BACKGROUND: Breastfeeding has beneficial effects on numerous health outcomes.OBJECTIVES: We investigated whether breastfeeding duration is associated with the development of early childhood autoimmunity, allergies, or obesity in a multinational prospective birth cohort.METHODS: Infants with genetic susceptibility for type 1 diabetes (n = 8676) were followed for the development of autoantibodies to
The AMP-activated protein kinase (AMPK) is a ubiquitously expressed kinase, which is activated in response to depletion of cellularenergy levels. Once active, it functions to alter cellular metabolism in a way that leads to restoration of energy levels. Therefore,AMPK is described as the key regulator of cellular energy homeostasis. Over the past years, AMPK activation has gained increasingattenti
Nätläkare, vårdgivare som tillhandahåller sjukvårdstjänster via smartphoneappar, har gått från att vara perifera inslag i den svenska sjukvården till att på allvar utmana det konventionella sättet att bedriva sjukvård. Den tillgänglighet som nätläkare erbjuder är oöverträffad men alla patientgrupper har inte sett sin tillgång till vård förbättras i samma utsträckning tack vare nätläkare.Syftet medOnline doctor services, healthcare provided via smartphone apps, have gone from being peripheral to seriously challenging the conventional Swedish way of providing healthcare services. The accessibility of online doctors is unsurpassed but all patient groups have not gotten better access to healthcare thanks to online doctors.The aim of this study was to investigate how perceptions of the online d
In the morning hours of April 11, the Natanz nuclear facility in Iran was attacked, allegedly by Israel. The strike came at a sensitive time, as Iran and world powers are discussing Washington’s return to the Joint Comprehensive Plan of Action (JCPOA) and the removal of sanctions. According to Israeli estimates, as the Islamic Republic does not wish to jeopardize a US return to the JCPOA, its resp
Recent reports state that firearm-related violence is increasing in Sweden. In order to understand the trend of firearm-related violence in Sweden with regard to rate, modus operandi (MO) and homicide typology, and for which injuries and causes of death firearm-related violence is responsible, a systematic literature review was conducted. After a thorough search in different databases, a total of
Intimate partner violence against women (IPVAW) is a global public health issue often assumed to be associated with gender inequality. The so-called Nordic Paradox, the apparently contradictory co-existence of high levels of IPVAW and of gender equality in Nordic countries, has not been adequately explained. This study explores discussions about how this apparent paradox can be understood among 30
The genus Eois Hübner (Geometridae: Larentiinae) comprises 254 valid species. Being a hyperdiverse genus, Eois potentially includes many undescribed cryptic species and embodies a problematic taxonomic scenario. The actual diversity of Eois is greatly underestimated and the Neotropical fauna needs to be well known since it figures as one of the most threatened terrestrial ecosystem. In the present
Objective: To investigate how genetics influence the risk of smoking-related systemic lupus erythematosus (SLE) manifestations. Methods: Patients with SLE (ndiscovery cohort=776, nreplication cohort=836) were genotyped using the 200K Immunochip single nucleotide polymorphisms (SNP) Array (Illumina) and a custom array. Sixty SNPs with SLE association (p<5.0×10-8) were analysed. Signal transducer an
Existing criteria for inclusion in the European baseline series are summarized. Additional criteria are developed to aid decision making where the current criteria do not yield an unequivocal result. These include a consideration of whether an allergen (hapten) is better placed in a special series and the frequency with which an allergen cross-reacts with existing markers in the baseline series.
In 2009, consistent with its objective to support and develop a European research infrastructure, the European Union (EU) created a neworganizational form for research collaborations: the European Research Infrastructure Consortium (ERIC). Since then, 21 different ERICs havebeen established in the EU Member States; the largest being the European Spallation Source (ESS).The financing of this ERIC i
Objective: Decreased kidney function increases cardiovascular risk and predicts poor survival. Estimated glomerular filtration rate (eGFR) by creatinine may theoretically be less accurate in the critically ill. This observational study compares long-term cardiovascular mortality risk by the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) creatinine equation; Caucasian, Asian, paediatri
The enoyl-acyl carrier protein (ACP) reductase (ENR) is a key enzyme within the bacterial fatty-acid synthesis pathway. It has been demonstrated that small-molecule inhibitors carrying the diphenylether (DPE) scaffold bear a great potential for the development of highly specific and effective drugs against this enzyme class. Interestingly, different substitution patterns of the DPE scaffold have b
