BACKGROUND: Most trials that have shown a benefit of beta-blocker treatment after myocardial infarction included patients with large myocardial infarctions and were conducted in an era before modern biomarker-based diagnosis of myocardial infarction and treatment with percutaneous coronary intervention, antithrombotic agents, high-intensity statins, and renin-angiotensin-aldosterone system antagon

Background: Measuring and interpreting vital signs in pediatric patients recovering from anaesthesia, particularly those up to 36 months old, is challenging. Nurses’ decision-making regarding the level of monitoring must balance patient safety with individualized care. This study aimed to explore the perceptions of critical care nurses and registered nurse anesthetists regarding their experiences

Grassroots innovations are seen as important contributors to sustainability transitions, however, given their dependence on place-specific conditions they face diffusion challenges. Responding to previously outlined gaps regarding conceptualisation and exploration of the spatiality of grassroots innovations, this paper introduces a conceptualisation of nomadic grassroots innovations. These are gra

India's ongoing energy transitions are a systemic response to addressing critical challenges associated with climate change. Importantly, it leverages decarbonization as a strategic pivot to simultaneously mitigate and adapt to climate risks. The decarbonization agenda is largely skewed towards mitigation, struggling with adaptation alignments. Energy justice is a core dimension of adaptation inte

Exposure time to heat is increasing with climate change. Heat exposure thresholds are important to inform heat early warning systems, and legislation and guidance for safety in the workplace. It has already been stated that thresholds can be lower for vulnerable groups, including the elderly, pregnant women, children, and those with pre-existing medical conditions due to their reduced ability to t

A neurological dogma is that the contralateral effects of brain injury are set through crossed descending neural tracts. We have recently identified a novel topographic neuroendocrine system (T-NES) that operates via a humoral pathway and mediates the left-right side-specific effects of unilateral brain lesions. In rats with completely transected thoracic spinal cords, unilateral injury to the sen

Ongoing climate variability and change are increasing the burden of diarrhoeal disease worldwide. Meaningful early warning systems with adequate lead times (weeks to months) are needed to guide public health decision–making and enhance community resilience against health threats posed by climate change. Toward this goal, we trained various machine-learning models to predict diarrhoeal disease rate

Heatwaves are the deadliest weather hazard and people and societies across the world continue to suffer from heat-related impacts. Future climate projections show a troubling increase in cross-sectoral impacts including health and economic risk presented by heatwaves. Many weather hazards such as floods and droughts already have a type of Early Warning System (EWS) or Global Alert System, but a gl

The notion of error plays an important role, this article argues, in Per Olov Enquist’s ground-breaking documentary novel Legionärerna (The Legionnaires) (1968), which depicts the controversial Swedish extradition of Baltic soldiers in January 1946. In terms of the plot (re)constructed by Enquist, Swedish politicians and Baltic soldiers as well as the novel’s investigator, a kind of alter ego of t

Om drottning Kristina.

Neuroblastoma (NB) is one of the most lethal childhood cancers due to its propensity to become treatment resistant. By spatial mapping of subclone geographies before and after chemotherapy across 89 tumor regions from 12 NBs, we find that densely packed territories of closely related subclones present at diagnosis are replaced under effective treatment by islands of distantly related survivor subc

BackgroundUnderstanding the heterogeneity of opioid overdose fatalities is critical to developing effective preventive interventions. This study examines patterns of care contacts among people who subsequently died from opioid overdose. The aim was to identify distinct groups of deceased individuals, based on their contacts with different care agencies in their last year of life.MethodsA retrospec

Andelen engelskspråkig undervisning och kurslitteratur ökar hela tiden på svenska universitet och högskolor. Men det finns mycket lite stöd för att det skulle gynna kvaliteten på utbildningen. Däremot finns det gott om forskning som indikerar motsatsen.

Lärarna underpresterar och studenternas lärande försämras. Så blir det när undervisningen sker på ett språk som varken är lärarnas eller studenternas modersmål, skriver förläggaren Ola Håkansson och forskaren Peter Svensson.

Objective: To evaluate hand and arm function and its association with motor symptoms as well as activities of daily living (ADL) in de novo Parkinson’s disease (PD).Background: Motor symptoms and disability in upper limb are common in PD and usually assessed using Unified PD Rating Scale (UPDRS). Activities, like reaching, grasping, manipulating objects, writing, dressing, and eating, may be more Objective: To evaluate hand and arm function and its association with motor symptoms as well as activities of daily living (ADL) in de novo Parkinson’s disease (PD).Background: Motor symptoms and disability in upper limb are common in PD and usually assessed using Unified PD Rating Scale (UPDRS). Activities, like reaching, grasping, manipulating objects, writing, dressing, and eating, may be more

BACKGROUND: Accumulating studies reported that several phosphodiesterases (PDEs) inhibitors might have cardiovascular benefits.OBJECTIVES: This study aimed to explore the relationship between genetically-predicted PDEs and ischemia heart disease via drug target Mendelian randomization (MR) approach, and then examine the effect of inhibitors of identified target on the outcomes by using real-world

Om Vilhelm av Ruysbroeck.