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We screened variants on an exome-focused genotyping array in >300,000 participants (replication in >280,000 participants) and identified 444 independent variants in 250 loci significantly associated with total cholesterol (TC), high-density-lipoprotein cholesterol (HDL-C), low-densitylipoprotein cholesterol (LDL-C), and/or triglycerides (TG). At two loci (JAK2 and A1CF), experimental analysis in m
Germline mutations in CDKN2A are frequently identified among melanoma kindreds and are associated with increased atypical nevus counts. However, a clear relationship between pathogenic CDKN2A mutation carriage and other nevus phenotypes including counts of common acquired nevi has not yet been established. Using data from GenoMEL, we investigated the relationships between CDKN2A mutation carriage
utomotive systems offer a rich opportunity for hybrid models, controls, and tools. Beyond the traditional use of hybrid models for representing the behavior of the composition of discrete controller and continuous plants, automotive mechanical systems exhibit hybrid behavior as demonstrated in this chapter. In addition, hybrid systems can be used to capture system specifications at the highest lev
In the last decades, emission legislation on pollutant emissions generated by road transportation sector has become the main driving force for internal combustion engine development. Approximately 20% of worldwide emissions of carbon dioxide from fuel combustion come from the transportation sector, and road vehicles contribute up to 80% of those emissions [1].Light-duty methane gas engines are usuIn the last decades, emission legislation on pollutant emissions generated by road transportation sector has become the main driving force for internal combustion engine development. Approximately 20% of worldwide emissions of carbon dioxide from fuel combustion come from the transportation sector, and road vehicles contribute up to 80% of those emissions [1]. Light-duty methane gas engines are us
Internal combustion engine (ICE) fuel efficiency is a balance between good indicated efficiency and mechanical efficiency. High indicated efficiency is reached with a very diluted air/fuel-mixture and high load resulting in high peak cylinder pressure (PCP). On the other hand, high mechanical efficiency is obtained with very low peak cylinder pressure as the piston rings and bearings can be made wInternal combustion engine (ICE) fuel efficiency is a balance between good indicated efficiency and mechanical efficiency. High indicated efficiency is reached with a very diluted air/fuel-mixture and high load resulting in high peak cylinder pressure (PCP). On the other hand, high mechanical efficiency is obtained with very low peak cylinder pressure as the piston rings and bearings can be made w
I denna rapport presenteras resultaten av den intervjustudie och efterföljande fokusgruppsdiskussion som vi genomfört inom ramen för forskningsprojektet Green Industrial Transitions (GIST, www.gist2050.com). Forskningsprojektets huvudsyfte är att studera förutsättningarna för en omställning till nollutsläpp av koldioxid inom den svenska basindustrin samt analysera strategier, åtgärder och styrmede
Reference Attribute Grammars (RAGs) is a declarative executable formalism used for constructing compilers and related tools. Existing implementations support concurrent evaluation only with global evaluation locks. This may lead to long latencies in interactive tools, where interactive and background threads query attributes concurrently.We present lock-free algorithms for concurrent attribute eva
This study uses aggregate data for 23 OECD countries over the 1960-1997 period to examine the relationship between macroeconomic conditions and fatalities. The main finding is that total mortality and deaths from several common causes increase when labor markets strengthen. For instance, controlling for year effects, location fixed effects, country-specific time trends and demographic characterist
Rhinovirus infections are common triggers of asthma exacerbations. Viruses can activate the inflammasome, resulting in processing and activation of caspase-1. This recruitment triggers production of interleukin (IL)-1β and IL-18, which have been implicated in asthma. Elucidating the involvement of the inflammasome and its compartments, such as caspase-1, in asthma exacerbations is warranted. Gene
BACKGROUND: The respiratory epithelium is a major site for disease interaction with inhaled allergens. Additional to IgE-dependent effects, allergens contain proteases that may stimulate human bronchial epithelial cells (HBECs) through protease-activated receptors, causing the release of mediators important in driving Th2 mediated immune responses.OBJECTIVE: We aimed to investigate if different al
Background & Aims Predniso(lo)ne, alone or in combination with azathioprine, is the standard-of-care (SOC) therapy for autoimmune hepatitis (AIH). However, the SOC therapy is poorly tolerated or does not control disease activity in up to 20% of patients. We assessed the efficacy of mycophenolate mofetil (MMF) and tacrolimus as second-line therapy for patients with AIH. Methods We performed a r
Stroke is one of the leading causes of mortality and morbidity worldwide, and few therapeutic treatments have shown beneficial effect clinically. One reason for this could be the lack of risk factors incorporated into the preclinical stroke research. We have previously demonstrated phenotypic receptor changes to be one of the injurious mechanisms occurring after stroke but mostly in healthy rats.
