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Hypereosinophilic syndrome in a child mosaic for a congenital triplication of the short arm of chromosome 8

An 11-year-old boy with mental retardation, malformations, and the mosaic karyotype 47,XY,+i(8p)/46,XY presented with fever, headache and petechiae. Peripheral blood WBC was 190 x 10(9)/l; and contained > 90% mature eosinophils. Cytogenetic analysis of the eosinophils revealed no aberrations except the constitutional karyotype. The patient was diagnosed as having a hypereosinophilic syndrome. Shor

Expanding the Social Dimension: Towards a Knowledge Base for Product-Service Innovation

The extension of businesses to incorporate the provision of function as a service in supplement to standalone products is an ongoing movement in manufacturing industry. In short, this means that the development intent should be guided by the need of ‘performance in use’ that the customer wants, e.g. thrust rather than an engine. By this, the established knowledge base challenges the development te

Demonstration of Two-Dimensional Temperature Characterization of Valves and Transparent Piston in a Gdi Optical Engine

Thermographic phosphors thermometry was used to measure engine valves and transparent piston temperatures in two dimensions as well point wise of a running, optically accessible, gasoline direct injection engine. The engine, fueled with isooctane, was operated in continuous and skip-fire mode at 1200 and 2000 rpm. A calibration of the phosphorescence lifetime and spectral properties against temper