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The specific insertion of a divalent metal ion into tetrapyrrole macrocycles is catalyzed by a group of enzymes called chelatases. Distortion of the tetrapyrrole has been proposed to be an important component of the mechanism of metallation. We present the structures of two different inhibitor complexes: (1) N-methylmesoporphyrin (N-MeMP) with the His183Ala variant of Bacillus subtilis ferrochelat

Ulf Arup fortsätter det mödosamma arbetet med att revidera det artrika släktet orangelavar, Caloplaca. I ett nyligen publicerat arbete i Lichenologist presenterade Ulf resultaten av en genetisk och morfologisk undersökning av C. holocarpa-gruppen och liknande arter i Norden (Arup 2009). Nedan ges en sammanfattande redogörelse för de resultaten.

Above its critical aggregation concentration the tfa salt of the peptide A(6)K self-assembles into micron long, hollow nanotubes with uniform diameters of 52 nm and crystalline order. Here we combine the use of SAXS with cryoTEM and cryo-electron tomography (cryoET, 3D cryoTEM) to study the formation process of the 2D crystalline A(6)K nanotubes. This study reveals that the formation of these tube

Background: Plasma phospholipid fatty acids have been correlated with food intakes in populations with homogeneous dietary patterns. However, few data are available on populations with heterogeneous dietary patterns. Objective: The objective was to investigate whether plasma phospholipid fatty acids are suitable biomarkers of dietary intakes across populations involved in a large European multicen

This paper investigates an allocation rule that fairly assigns at most one indivisible object and a monetary compensation to each agent, Under the restriction that the monetary compensations do not exceed some exogenously given upper bound. A few properties of this allocation rule are stated and the main result demonstrates that the allocation rule is coalitionally strategy-proof. (C) 2008 Elsevie

Objective. The prevalence of anemia in inflammatory bowel disease (IBD) has been broadly described. The recurrence, type and burden of anemia remain unenlightened. The primary objective was to describe this. The secondary objective was to evaluate the implementation of European guidelines. Materials and methods. This longitudinal follow-up study included 300 IBD outpatients from six centers in Sca

The importance of proper mutational analysis of BRCA1/2 in individuals at risk for hereditary breast and ovarian cancer syndrome is widely accepted. Standard genetic screening includes targeted analysis of recurrent, population-specific mutations. The purpose of the study was to establish the frequency of germline BRCA1/2 mutations in a group of 134 unrelated patients with primary ovarian cancer.

Decays of neutron-rich A similar to 190 nuclei have been studied following projectile fragmentation of a Pb-208 beam on a Be-9 target at the GSI Fragment Separator. Gamma-ray decays from previously reported isomeric states in Ta-188, W-190 and (192,193) Re were used as internal calibrations for the particle identification analysis, together with the identification of previously unreported isomeric

The presence of I-129 in the environment has been strongly influenced by the artificial nuclear emissions since the beginning of the nuclear era in the mid 20th century. In order to know more about the different sources and their relative impact in different zones, it is necessary to complete the amount of measurements of this radionuclide in environmental samples. In this work, I-129 has been det

Presumed effects of global warming on occupational heat stress aggravate conditions in many parts of the world, in particular in developing countries. In order to assess and evaluate conditions, heat stress must be described and measured correctly.

This purpose of the study was to increase the visibility on radar for unprotected pedestrians with the aid of conducting fabric. The experiment comprised measurements of four types of fabric to determine the radio frequency properties, such as radar cross section (RCS) for the vehicle radar frequency 77 GHz and transmission (shielding) in the frequency range 3-18 GHz. Two different thicknesses of

Study design:Register study.Objectives:To design and implement a validation process to check the completeness of the Hospital Discharge Register (HDR) held by the Swedish National Board of Health and Welfare.Setting:Sweden.Methods:An accurate traumatic spinal cord injury prevalence group (n=495) was acquired from the Swedish Spinalis Clinic. A register control was performed on the group by raising

It appears to be relatively common to assume that negative apparent chargeability data in time-domain induced polarisation (IP) surveying is a sign of bad data quality. Negative IP data can however occur as a consequence of the distribution of chargeable zones in the ground, which is well documented in literature. A general mechanism behind negative IP data is proposed as follows; if the chargeabl

OBJECTIVE: Our aim was to investigate exposure to polybrominated diphenyl ethers (PBDEs) in a young urban population in a developing country, with focus on potentially highly exposed children working informally as scrap scavengers at a large municipal waste disposal site. We also set out to investigate whether hydroxylated metabolites, which not hitherto have been found retained in humans, could b

We here discuss the potential theranostic nanomedicine application of an innovative formulation consisting of monoolein-based nanoparticles with a two-dimensional hexagonal inner structure stabilized in water using a mixture of PEO132-PPO50-PEO132 block copolymers with and without conjugated folate for targeting. The proposed tumor-cell targeted formulation was shown to be able to simultaneously h

This narratological study deals with the stance of irony in Jane Austen’s juvenilia. It looks for ‘gaps’ between the attitudes of implied authors, narrators and characters, and investigates how these gaps contribute to the irony of the texts. Once it has been established that the implied author has an ‘ironic intent’, the primary question is whether the narrator shares this intent. Some narrators