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Radiosonde observations represent one of the most reliable and relevant methods of vertical profile measurements of the upper air metrological observations. Despite its importance in Numerical weather prediction (NWP), radiosonde observations suffer from persistent data gaps resulting from sensor failure, critical environment conditions, and signal interference. Therefore, there is a growing need
Background – Ventricular–arterial coupling (VAC) integrates cardiac and vascular function and has emerged as a relevant marker of cardiovascular efficiency and adaptability. Exercise and physical activity are believed to influence VAC through multiple physiological pathways, yet the scope, methods, and consistency of available evidence remain unclear. Objective – To map and characterize the existi
Low-cost capacitive (LCC) soil moisture sensors have considerable potential for precision agriculture due to their low cost, low energy consumption, and suitability for IoT-based systems. However, their field performance and the transferability of laboratory calibration to field conditions remain insufficiently documented. The objective of this study was to evaluate the field performance of LCC se
Progressive supranuclear palsy-Richardson’s syndrome (PSP-RS) is a primary 4R tauopathy in which early axonal dysfunction may precede overt neurodegeneration; however, the mechanisms linking Tau dysregulation to cytoskeletal vulnerability remain poorly defined. Here, we generated induced pluripotent stem cell (iPSC)-derived midbrain dopaminergic neurons from individuals with sporadic PSP-RS and ma
This work presents a framework for the simulation of the Directed Energy Deposition with a Laser Beam (DED-LB) additive manufacturing process by using the Particle Finite Element Method (PFEM). PFEM offers key advantages, especially its ability to handle large and rapidly changing deformations in the domain of molten metal flow through its remeshing strategy, and to simulate the bonding of separat
The crisis of the Liberal International Order (LIO) has intensified amid growing great-power competition, the war in Ukraine, and the erosion of multilateral institutions. This Forum examines security assistance (SA)—the training, equipping and support of external security actors—as a critical lens for understanding how this crisis is unfolding and how international order is increasingly contested
Background: To find an alternative for the time-consuming Dutch clinician-based Constant Murley score (c-CMS), we assessed its interchangeability with the patient-based CMS (p-CMS) in patients undergoing arthroplasty. Also, we assessed test-retest reproducibility of both CMS versions. Methods: The English p-CMS was translated into Dutch using forward and backward translation. We administered the c
This article focuses on the Governments social welfare reforms that relates to benefit caps and activation demands relevant for children’s rights to social security and adequate standard of living. The aim is to study the Govern-ments basis for reform policy departing from Daly’s social policy typology (2020). The basis for the reformed policies emphasizes two basic
Background: The radiosensitizing effect of epidermal growth factor inhibitors (EGFRIs), such as cetuximab, in patients with p16-positive HPV-associated oropharyngeal squamous cell carcinoma (HPV + OPSCC) is not clear. There is no randomized trial investigating the addition of EGFRI to radiotherapy (RT) alone specifically in HPV + OPSCC, and available evidence in subgroup analyses have mostly sugge
The goal to control short-wavelength radiation for the investigation and manipulation of ultrafast dynamics in quantum systems coevolves with the growing availability of extreme-ultraviolet (XUV) and x-ray sources from high-harmonic generation and free-electron lasers. Here, we present an XUV spatio-spectral phase modulator based on an intense XUV laser beam propagating through an optically thick
Owing to the global incentives targeted towards the advancement of semiconductor science and technology, the importance of a reliable method for the fundamental characterization of the interface between metals and low-dimensional semiconductors cannot be emphasized enough. For decades now, X-ray photoelectron spectroscopy (XPS) has been relied upon rather heavily when it comes down to investigatin
Background: Calprotectin, a neutrophil activation marker, is a promising diagnostic biomarker for infection and sepsis, but its usefulness in the emergency department (ED) is unclear. The aim of this study was to investigate the diagnostic value of calprotectin for sepsis and the source of infection in the ED. Methods: A total of 583 prospectively included patients presenting with suspected sepsis
The right of patients to decline information about their health, prognosis, and available treatment options is a salient principle in both domestic law and international declarations and conventions. This right may be considered either unnegotiable or subject to certain terms and conditions. While respecting this right may seem straightforward, doing so in clinical practice can be challenging. Thi
Evaluating agri-environmental measures that support both biodiversity and productive agriculture requires bio-economic models capable of estimating trade-offs between economic and ecological functions, including multifunctionality—the simultaneous provision of multiple functions. These models must account for how landscape composition and configuration influence function delivery. For instance, po
Type 2 diabetes (T2D) is a major global health concern strongly associated with atherosclerosis and subsequent macrovascular complications. These complications are the leading cause of death among T2D patients. Despite a decline in cardiovascular events over the last decade, individuals with T2D still have an approximately doubled risk compared to those without diabetes. This shows an urgent need
The precision goal on the Cabibbo-Kobayashi-Maskawa matrix elements |Vus| and |Vud| requires the inclusion of isospin-breaking effects. These effects, associated to QED and the light-quark mass difference, can be included in lattice QCD+QED simulations. The long-range nature of QED, however, poses a problem for finite-volume lattice simulations that necessitates the adoption of a prescription for
This paper presents a method for mathematical modelling of surfaces conditioned on empirical data. It is based on solving a discrete biharmonic equation over a domain with given inner point and inner curve data. The inner curve data is used to model boundary values while the inner point data is used for modeling a load vector with the goal to generate a smooth surface. The construction of boundary
This chapter presents the ICECAP-O, a measure of capability tailored for older people. It briefly presents the original version of the ICECAP-O. In addition, it describes the work that has been done concerning the translation and cross-cultural adaptation of the ICECAP-O to the Swedish context. Finally, the chapter contains arguments for the use of the Swedish version of the ICECAP-O in health and
