Chronic myeloid leukemia (CML) is genetically characterized by the Philadelphia (Ph) chromosome, formed through a reciprocal translocation between chromosomes 9 and 22 and giving rise to the constitutively active tyrosine kinase P210 BCR/ABL1. Therapeutic strategies aiming for a cure of CML will require full eradication of Ph chromosome-positive (Ph(+)) CML stem cells. Here we used gene-expression

The expression of the tumor suppressor p53 can influence the bioactivation of, and DNA damage induced by, the environmental carcinogen benzo[a]pyrene, indicating a role for p53 in its cytochrome P450 (CYP)-mediated biotransformation. The carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), which is formed during the cooking of food, is also metabolically activated by CYP enzymes, par

Non-invasive tests for the detection of peripheral artery disease (PAD) among individuals with diabetes mellitus (DM) are important to estimate the risk of amputation, ulceration, wound healing and presence of cardiovascular disease, yet there are no consensus recommendations to support a particular diagnostic modality over another. To evaluate the performance of index non-invasive diagnostic test

Health related quality of life (HRQoL) was assessed in the randomised, prospective ARTSCAN study comparing conventional radiotherapy (CF) with accelerated radiotherapy (AF) for head and neck cancer.

AIM: To evaluate long-term endocrine and exocrine pancreatic function, quality of life and health care costs after mild acute pancreatitis and severe acute pancreatitis (SAP). METHODS: Patients prospectively included in 2001-2005 were followed-up after 42 (36-53) mo. Pancreatic function was evaluated with laboratory tests, the oral glucose tolerance test (OGTT), fecal elastase-1 and a questionnair

We present a stopping condition to the duality based distributed optimization algorithm presented in [1] when used in a distributed model predictive control (DMPC) context. To enable distributed implementation, the optimization problem has neither terminal constraints nor terminal cost that has become standard in model predictive control (MPC). The developed stopping condition guarantees a prespec

Computational prediction methods are widely used for analysis of human genome sequence variants and their effects on gene/protein function, splice site aberration, pathogenicity, and disease risk. New methods are frequently developed. We believe that guidelines are essential for those writing articles about new prediction methods, as well as for those applying these tools in their research, so tha

Signal transduction in response to growth factors is a strictly controlled process with networks of feedback systems, highly selective interactions and finely tuned on-and-off switches. In the context of cancer, detailed signaling studies have resulted in the development of some of the most frequently used means of therapy, with several well established examples such as the small molecule inhibito

BACKGROUND: The in vivo clinical significance of malignant stem cells remains unclear. METHODS: Patients who have the 5q deletion (del[5q]) myelodysplastic syndrome (interstitial deletions involving the long arm of chromosome 5) have complete clinical and cytogenetic remissions in response to lenalidomide treatment, but they often have relapse. To determine whether the persistence of rare but dist

OBJECTIVES: The aim of this study was to investigate disclosure rates and disclosure patterns and to examine predictors of non-disclosure in a sample of male and female adolescents with self-reported experiences of sexual abuse. METHOD: A sample of 4,339 high school seniors (2,324 girls, 2,015 boys) was examined with a questionnaire concerning sexual experiences in this study with a focus on discl

Aiming to clarify the adult phenotype of antisocial personality disorder (ASPD), the empirical literature on its childhood background among the disruptive behaviour disorders, such as attention deficit/hyperactivity disorder (AD/HD), oppositional defiant disorder (ODD), conduct disorder (CD), or hyperkinetic conduct disorder (HKCD), was reviewed according to the Robins and Guze criteria for nosolo

In this study using cross-sectional survey data from suburban and rural Scania, Sweden (N=24,847), we assessed how the recently validated index score of area-aggregated perceived green neighborhood qualities (Scania Green Score; SGS), and the five distinct qualities within this index were associated with three self-reported indicators of well-being: neighborhood satisfaction, physical activity and

This work describes a novel fully integrated inductive tongue computer interface for disabled people. The interface consists of an oral unit placed in the mouth, including inductive sensors, related electronics, a system for wireless transmission and a rechargeable battery. The system is activated using an activation unit placed on the tongue, and incorporates 18 inductive sensors, arranged in bot

This paper presents an efficient numerical method for designing PI controllers. The design is based on optimization of load disturbance rejection with constraints on sensitivity and weighting of set point response. Thus, the formulation of the design problem captures three essential aspects of industrial control problems, leading to a non-convex optimization problem. Efficient ways to solve the pr

The sequence of 15.7 kb from the human semenogelin gene locus has been determined. Together with previously published sequences, this gives the structure of a 28-kb region encompassing the two semenogelin genes. The two transcription units are separated by 11616 bp intergenic DNA comprising more than 40% repetitive DNA sequences, predominantly located to a 4-kb block of L1 and Alu repeats. Two mor

We present the DEAL language for heap assertions that are efficiently evaluated during garbage collection time. DEAL is a rich, declarative, logic-based language whose programs are guaranteed to be executable with good whole-heap locality, i.e., within a single traversal over every live object on the heap and a finite neighborhood around each object. As a result, evaluating DEAL programs incurs ne