BakgrundFör att tackla den rådande SARS-COV-2-pandemin har det ställts höga krav på en snabb utveckling och utvärdering av nya antivirala läkemedel. Bland några av de antivirala läkemedelskandidaterna finns imiquimod, en TLR7 agonist normalt administrerad för behandling av könsvårtor och basalcellscarcinom. Eftersom det har påvisats att imiquimod kan öka den antivirala responsen, är vår hypotes at

Small cell lung cancer (SCLC; accounting for approximately 13%–15% of all lung cancers) is an exceptionally lethal malignancy characterized by rapid doubling time and high propensity to metastasize. In contrast to the increasingly personalized therapies in other types of lung cancer, SCLC is still regarded as a homogeneous disease and the prognosis of SCLC patients remains poor. Recently, however,

The cardiac hormone atrial natriuretic peptide (ANP) is a central regulator of blood volume and a therapeutic target in hypertension and heart failure. Enhanced ANP activity in such conditions through inhibition of the degradative enzyme neprilysin has shown clinical efficacy but is complicated by consequences of simultaneous accumulation of a heterogeneous array of other hormones. Targets for spe

Background: Medical devices are increasingly being reported to cause contact allergic dermatitis reactions. Objective: Review of patients with diabetes type I referred for suspected allergic contact dermatitis to insulin pump or glucose sensor systems. Method: We have reviewed 11 referred diabetes mellitus patients investigated for allergic contact dermatitis reactions to medical devices and speci

Hamming code-based LDPC (H-LDPC) block codes are obtained by replacing single parity-check codes in Gallager's LDPC codes with Hamming constituent codes. This paper investigates the asymptotic error-correcting capabilities of ensembles of random H-LDPC codes, used over the binary symmetric channel and decoded with a low-complexity hard-decision iterative decoding algorithm. The number of required

In this article, I explore the reception of American “quality” serial television in Sweden from 1999 to the mid-2010s. My analysis includes how cultural critics and journalists writing for Sweden's leading newspapers conceptualised American serial television as “quality TV” and as legitimate “art”, and it charts the ways in which these discourses relate to the reconfiguration of Swedish television

Monoclonal antibody therapies are effective for many but not all people with severe asthma. Precision medicine guides treatment selection using biomarkers to select patients most likely to respond according to their inflammatory endotypes. However, when assessing response to treatment, greater precision is required. We report a case series describing treatment response to mepolizumab in four sever

Antagonistic interactions between the sexes are important drivers of evolutionary divergence. Interlocus sexual conflict is generally described as a conflict between alleles at two interacting loci whose identity and genomic location are arbitrary, but with opposite fitness effects in each sex. We build on previous theory by suggesting that when loci under interlocus sexual conflict are located on

Bloggpost för New Review of Film and Television Studies "Short Cuts"-bloggBlog post for New Review of Film and Television Studies "Short Cuts" blog.

Artificial mechanical perturbations affect chromatin in animal cells in culture. Whether this is also relevant to growing tissues in living organisms remains debated. In plants, aerial organ emergence occurs through localized outgrowth at the periphery of the shoot apical meristem, which also contains a stem cell niche. Interestingly, organ outgrowth has been proposed to generate compression in th

We have analyzed the link between the gene regulation and growth during the early stages of flower development in Arabidopsis. Starting from time-lapse images, we generated a 4D atlas of early flower development, including cell lineage, cellular growth rates, and the expression patterns of regulatory genes. This information was introduced in MorphoNet, a web-based platform. Using computational mod

Geological archives record multiple reversals of Earth’s magnetic poles, but the global impacts of these events, if any, remain unclear. Uncertain radiocarbon calibration has limited investigation of the potential effects of the last major magnetic inversion, known as the Laschamps Excursion [41 to 42 thousand years ago (ka)]. We use ancient New Zealand kauri trees (Agathis australis) to develop a

This article argues that imprisonment is a liminal experience and that recognitionis needed to establish a new social status to enable parity of participation afterone’s release. The article builds on photographic action research done with fourformer political prisoners in Myanmar, and analyzes three of the photos from theproject and the process of creating and exhibiting photos. The article shows

This paper presents a fully integrated 60 GHz frontend for phased array receivers. For the first time in the literature a phase controlled phased locked loop (PC-PLL) is used for beamforming at 60 GHz. The front-end performs a two stage frequency down-conversion, first from 60 GHz to 20 GHz, then from 20 GHz to quadrature baseband. Both the local oscillator signals at 20 GHz and 40 GHz are generat