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Lignin is the second most abundant biopolymer on Earth after cellulose, found in virtually all plantswhere it is responsible for rigidity, hydrophobicity and mineral transport. For a long time, it has been considereda waste in the paper production process and incinerated for its energy content. However, with the depletion ofcrude oil reserves, it has been found to have a large potential to become

Continuous experimentation (CE) is used by many internet-facing companies to improve the value of their products based on user feedback gathered, e.g. through on-line experiments using A/B testing. Frameworks and theories for CE have been derived through academic research from applications in large internet facing companies. To assist practitioners in a broader range of companies, we herein presen

BACKGROUND: Acute ischemic stroke triggers endothelial activation that disrupts vascular integrity and increases hemorrhagic transformation leading to worsened stroke outcomes. rt-PA (recombinant tissue-type plasminogen activator) is an effective treatment; however, its use is limited due to a restricted time window and hemorrhagic transformation risk, which in part may involve activation of MMPs

Aims: An increase in psychosomatic symptoms among adolescents has recently been reported. Few studies have examined the relation between food intake and psychosomatic symptoms. The aim was to study the association between food intake and overall psychosomatic burden and separate psychosomatic symptoms. Methods: In this cross-sectional study, we used data from 6248 girls and 7153 boys in south-east

INTRODUCTION: Amyloid beta and tau pathology are the hallmarks of sporadic Alzheimer's disease (AD) and autosomal dominant AD (ADAD). However, Lewy body pathology (LBP) is found in ≈ 50% of AD and ADAD brains. METHODS: Using an α-synuclein seed amplification assay (SAA) in cerebrospinal fluid (CSF) from asymptomatic (n = 26) and symptomatic (n = 27) ADAD mutation carriers, including 12 with known

Climate change is predicted to cause milder winters and thus exacerbate soil freeze–thaw perturbations in the subarctic, recasting the environmental challenges that soil microorganisms need to endure. Historical exposure to environmental stressors can facilitate the microbial resilience to new cycles of that same stress. However, whether and how such microbial memory or stress legacy can modulate

The paper contributes to re-viewing entrepreneurial universities by expanding the understanding of the role and impact of alumni engagement in this context. Embedded in a stakeholder theory perspective, we develop and test a framework thatidentifies social, behavioural, cognitive and affective drivers of alumni engagement. We conducted statistical analyses to test hypotheses on a sample of 493 ent

Recent experimental advances have made it possible to detect individual quantum jumps in open quantum systems, such as the tunneling of single electrons in nanoscale conductors or the emission of photons from nonclassical light sources. Here, we investigate theoretically the statistics of photons emitted from a microwave cavity that is driven resonantly by an external field. We focus on the differ

Understanding high-order biexciton dynamics is important for the use of semiconductor quantum dots (QDs) in optoelectronic devices. The core–shell structure can be used to modulate biexciton dynamics by varying the shell thickness and core–shell energy band alignment. In this study, the biexciton dynamics in an unconventional case in which each QD is encapsulated by a submonolayer shell are demons

Body dysmorphic disorder (BDD) is a prevalent and impairing psychiatric condition that typically debuts in adolescence and is associated with risky behaviours. The disorder can be effectively treated with cognitive behaviour therapy (CBT). However, CBT for BDD is seldom available primarily due to a shortage of trained therapists. Internet-delivered CBT (ICBT) can be a way to increase treatment ava

This paper presents the results of an experimental campaign designed to compare and understand the performance of passive protection under exposure to standard furnace tests and natural fires. As part of this campaign, five natural fire experiments were performed with partially protected cross-laminated timber (CLT) compartments under a range of ventilation conditions. In all the tests, only one s

The transition to agile manufacturing, Industry 4.0, and high-mix-low-volume tasks require robot programming solutions that are flexible. However, most deployed robot solutions are still statically programmed and use stiff position control, which limit their usefulness. In this paper, we show how a single robot skill that utilizes knowledge representation, task planning, and automatic selection of

Whereas the validity of deductive inferences can be characterized in terms of their logical form, this is not true for all inferences that appear pre-theoretically valid. Nonetheless, philosophers have argued that at least some of those inferences—sometimes called “similarity-based inferences” —can be given a formal treatment with the help of similarity spaces, which are mathematical spaces purpor

Automatic segmentation of skin lesion is still challenging due to ambiguous boundary and noise interference of lesion regions. Recent exiting Transformer-based methods often directly apply Transformer to obtain long-range dependency to overcome these problems. However, they generally do not consider that patch partitioning strategy of Transformer could lead to the loss of local details around boun

Context: Continuous experimentation (CE) is used by many companies with internet-facing products to improve their business models and software solutions based on user data. Some companies deliberately adopt a systematic experiment-driven approach to software development while some companies use CE in a more ad-hoc fashion. Objective: The goal of this study is to identify factors for success in CE

Reconstructions of past land use and related land-cover changes at local and regional scales are needed to evaluate the potential long-term impacts of land use on the coastal waters of the Baltic Sea. In this purpose, we selected the Gamleby area at the Swedish Baltic Sea coast for a case study. We use a new, high resolution pollen record from a small lake (Lillsjön) located 3.6 km NNW of the bay

Swelling is the most fundamental property of graphite oxides (GO). Here, a structural study of Brodie graphite oxide (BGO) swelling in a set of long chain 1-alcohols (named C11 to C22 according to the number of carbons) performed using synchrotron radiation X-ray diffraction at elevated temperatures is reported. Even the longest of tested alcohols (C22) is found to intercalate BGO with enormous ex

Background: A growing evidence base supports the use of autologous haematopoietic stem cell transplantation (aHSCT) for treatment of relapsing-remitting multiple sclerosis (RRMS), but it has not yet been integrated into most national clinical guidelines. The objective of this study was to assess efficacy and safety when aHSCT is implemented in routine healthcare. Methods: We assessed 231 patients

Fire has the potential to create significant impacts on the built environment. Managing this impact is sometimes pursued without consideration of the interface between the natural and technological worlds. However, as society has recognized the impacts of technological development on environmental sustainability, the need for sustainable and resilient development has emerged. To facilitate sustain