Filtyp
INTRODUCTION: We assessed the accuracy of the Amsterdam Instrumental Activities of Daily Living Questionnaire (A-IADL-Q) for clinical staging in Swedish primary care.METHODS: Participants from the Swedish BioFINDER Primary Care study were included. Discriminative performance of the A-IADL-Q was evaluated using receiver operating curves. Multinomial and linear regression models assessed association
Heavy-duty transport is one of the major contributors to global greenhouse gas (GHG) emissions, with internal combustion engines (ICEs) expected to remain an important propulsion technology in long-haul applications during the transition to sustainable transport. The use of renewable gaseous fuels such as biogas and hydrogen offers a promising pathway to significantly reduce the climate impact of
Neoliberal welfare reforms and limited pathways to permanent residency have left migrant women, among other groups, with little or no access to public social protection, contributing to their precarious legal status. As a result, civil society actors (CSA) have become the main providers of support and deliver micro-level social protection beyond the boundaries of public authorities. At the same ti
p53 protein accumulation and gene mutation have been implicated in resistance to cytotoxic treatment. This study was performed to further assess the predictive value of p53 in breast cancer. Postmenopausal patients were randomized to adjuvant chemotherapy with cyclophosphamide, metothrexate, or 5-fluorouracil (CMF) vs. postoperative radiotherapy. The patients were also randomized to adjuvant tamox
Scholars have shown that lifestyle change is pivotal for any effective climate-mitigation scenario. But what lifestyle changes are needed and how can they be enabled and mainstreamed? This is the question pursued by the EU 1.5° Lifestyles project, the results of which the article summarizes and synthesizes. The project integrated quantitative and qualitative methods, ranging from input-output anal
The aim of this study was to investigate the frequency of p53 alterations in bilateral breast cancer and to evaluate a possible clonal relationship between the paired tumours regarding p53 alteration and other pathobiological variables. Tumours from 34 patients were investigated with immunohistochemistry, single strand conformation polymorphism analysis and DNA-sequence analysis applied to exons 5
Accumulation of the tumour-suppressor protein p53 in breast cancer is associated with several prognostic factors that indicate an aggressive, rapidly proliferating tumour with an unstable genome. To assess p53 accumulation in stage I breast cancer and to evaluate the prognostic value of both nuclear and cytoplasmic p53, 205 patients with node-negative breast cancer and tumour size less than or equ
Functional p53 protein is essential for the cellular response to drug-induced DNA damage. We investigated p53 accumulation in tumour specimens from premenopausal breast cancer patients who were randomised to adjuvant chemotherapy (CMF) or postoperative radiotherapy. Of the tumours from 139 patients, 20 showed abnormal accumulation as judged with immunohistochemistry (> 10% positive tumour cells).
A novel quantitative luminometric immunoassay (LIA) has been developed for the measurement of wild-type and mutant p53 protein in extracts from breast tumour tissue. The LIA was found to yield reliable estimates of p53 expression in cytosol samples routinely prepared for steroid receptor analysis as compared with results obtained with immunohistochemical analysis. The LIA was evaluated on 205 prim
Knut Wicksell var en banbrytande nationalekonom. Hans penningteori styr fortfarande dagens politik. Och han deltog med liv och lust i den offentliga debatten. Lars Jonung minns en svensk provokatör som blev internationellt erkänd.
Juvenile polyposis syndrome (JPS) is a rare genetic disorder characterized by juvenile polyps of the gastrointestinal tract. We present a new pathogenic mutation of the SMAD4 gene and illustrate the need for a multidisciplinary health care approach to facilitate the correct diagnosis. The patient, a 47-year-old Caucasian woman, was diagnosed with anaemia at the age of 12. During the following 30 y
Children undergoing surgery for posterior fossa tumours (PFT) may experience postoperative language and communication difficulties, regardless of whether they develop cerebellar mutism syndrome (CMS) or not. While these language difficulties are increasingly recognised in current research, children’s own experiences of everyday communication remain limited. In this presentation, we share findings
PurposeTo explore the cultural embeddedness of (un)welcome experiences among ethnically marginalized consumers in retail spaces.Design/methodology/approachDrawing on Arjun Appadurai's notion of the ethnoscape, the study is empirically grounded in critical-incident interviews with consumers from multiethnic backgrounds in Sweden.FindingsThree dimensions through which (un)welcome is negotiated are i
To examine longitudinal trajectories of pain occurrence in children with cerebral palsy (CP) aged 1 year to 17 years.A longitudinal register-based study was conducted using data from the Swedish Cerebral Palsy Follow-up Program (2007-2023). Individuals (n = 4887) with confirmed CP, a minimum of three pain assessments, and any Gross Motor Function Classification System (GMFCS) levels were included
Incretin-based therapies, including glucagon-like peptide-1 receptor agonists (GLP-1RAs), are approved for the treatment of type 2 diabetes, obesity, and related conditions, and have demonstrated significant benefits for individuals with these conditions. However, in recent years, public interest and demand for GLP-1RAs-often driven by media, social media influencers, advertising, and public disco
