From serendipity to precision: investigating pH-induced oligomerization switch for protein control
Understanding the pH sensitivity of proteins and enzymes across intracellular compartments is crucial for fundamental research. Lizatović et al. [1] aimed to design a peptide incorporating a specific amino acid to form a hexamer structure and lacking it to form a pentamer structure. Unexpectedly, two distinct structures emerged based on pH. At pH 6, a hexamer structure formed, albeit with a surpri