Reliable data on familial risks are important for clinical counselling and cancer genetics. However, the estimates of familial risk of gastric cancer vary widely. We examined the risk of familial gastric cancer using the updated Swedish Family-Cancer Database with 5358 patients among offspring and 36 486 patients among parents. There were 133 families with one parent and one offspring diagnosed wi

Water shortages across the globe have increased due to climate change among other factors with negative impacts expected at the river basin level. Anticipating these impacts will help experts act in a timely manner to avoid a future water crisis. As part of addressing the future water shortage impacts on the Togolese community, this paper assessed water security in the context of the global enviro

This study evaluated factors underlying individual differencesin spontaneous (unsuggested) experiences during hypnosis.Participants varying in hypnotizability (low, medium, and high) completeda questionnaire about various dimensions of consciousness theywould expect to experience at the “deepest level of hypnosis” (expectancy),an eyes-closed resting condition (baseline), and their actualexperience

BACKGROUND: Fast-track referral is an increasingly used method for diagnostic evaluation of patients suspected of having cancer. This approach is challenging and not used as often for patients with only nonspecific symptoms. In order to expedite the diagnostics for these patients, we established Sweden's first Diagnostic Center (DC) focusing on outcomes related to diagnoses and diagnostic time int

Risk of breast cancer is temporarily elevated shortly after pregnancy and the available limited data suggest that a family history of breast cancer may reinforce the risk. We used the nation-wide Swedish Family-Cancer Database to estimate the relative risk (RR) for invasive breast cancer following childbirth among women with or without a family history. The RRs were defined using Poisson regressio

Introduction. Earlier studies suggest that histology has no prognostic significance in patients with invasive ovarian tumors. Studies about the effect of family history on survival have given conflicting results, which we try to clarify in this study. As an additional question, we examined whether family members share survival experience. Methods. We used the nation-wide Swedish Family-Cancer Data

Context: Familial clustering of a disease is an indicator of a possible heritable cause. In the era of genome scans, the consideration of data on heritability should be important in the assessment of the likely success of the scans. Object: The objective of the study was to carry out a family study on nonthyroid endocrine diseases to search familial clustering of these diseases beyond the known sy

Several earlier studies have assessed survival in breast cancer based on familial risk of this disease. The results have been conflicting and suggest that the risk and prognostic factors of cancer are largely distinct. As a novel concept, we searched for familial clustering of survival, i.e., concordance of survival among family members. We used the nation-wide Swedish Family-Cancer Database to es

Background: Family history has been reported to be associated with an increased risk of pancreatic cancer. However, its possible influence on pancreatic cancer survival has rarely been studied, probably because of the rareness of cases in the same family. Methods: We used the nationwide Swedish Family-Cancer Database to examine the survival differences between familial and sporadic pancreatic canc

Survival from soft tissue tumors (STTs) has been improved because of the successful treatment. One of the late sequelae in STT survivors is the development of a second malignancy. The present study aimed at quantifying risks for second malignancies in patients with STTs, and risks for second STTs after other primary malignancies. Adjusted standardized incidence ratios (SIRs), calculated from the S

AIMS: In the era of genome-wide association studies, familial risks are used to estimate disease heritability and success in gene identification. We wanted to estimate associations of 42 autoimmune diseases with attention-deficit hyperactivity disorder (ADHD) between individuals and family members.PARTICIPANTS AND METHODS: The availability of a Multigeneration Register in Sweden provides reliable

Background & Aims: Familial risks for esophageal cancer are not well known, especially for specific histologic types. Methods: We used the nationwide Swedish Family-Cancer Database to examine familial risks for esophageal cancer in offspring. Standardized incidence ratios (SIRs) and 95% confidence intervals (CIs) were used to calculate the risk. Age standardized incidence rates for specific hi

Aim: To study association between country of birth and risk of first-onset atrial fibrillation (AF) in first- and second-generation immigrants to Sweden under 45 y of age.Methods: The study population included all individuals (n = 3 248 457) under the age of 45 y in Sweden, including immigrants (n = 722 249). AF was defined as first registered diagnosis in the National Patient Register. Associatio

Purpose: The aim of the study is to investigate associations between socioeconomic and occupational factors and lymphoproliferative (LP) diseases. Methods: We performed a follow-up study on the economically active Swedish population, based on the Swedish Family-Cancer Database. Standardized incidence ratios and 95% confidence intervals were calculated in different social classes and occupations. R

We used the nation-wide Swedish Family-Cancer Database to examine the familial risks of histology-specific bone cancers in offspring by parental or sibling probands. Adjusted standardised incidence ratios (SIRs) were used to measure the risk. Among the 1327 offspring bone cancers, only two parent-offspring pairs and one sibling pair were noted with concordant bone cancer but the SIRs were not sign

Objectives: Gallstone disease (cholelithiasis) has a familial component, but detailed data on the modification of familial risk are lacking. Using nationwide hospital and population records, we aimed to determine detailed familial risks for medically diagnosed gallstone disease.Design: Subjects were obtained from the Multigeneration Register, which contains family data on the Swedish population, a

Objective: The objective of this study was to examine the associations between socioeconomic/Occupational factors and histologic subtypes of leukemia. Methods: The Swedish Family-Cancer Database was used to calculate standardized incidence ratios for different social classes and occupational groups. Results: The overall standardized incidence ratio was close to unity between different socioeconomi

Although many studies have examined the associations between occupational exposures and kidney cancer, the evidence is not consistent. To examine the risk of occupational exposures on kidney cancer, we carried out a follow-up study on the economically active Swedish population, based on the latest update of the Swedish Family-Cancer Database. We calculated standardized incidence ratios (SIR) and 9

Objectives: We sought to examine the associations between occupation and upper aerodigestive tract cancers at various anatomic sites. Methods: The Swedish Family-Cancer Database was used to calculate standardized incidence ratios for different occupational groups, adjusted for age, period, and socioeconomic status. Results: Male dentists showed an increased risk for tongue cancer; hairdressers had