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Numerical and experimental investigation of residual stresses during the induction hardening of 42CrMo4 steel

The usage of induction hardening in the industry has increased in the last years due to its efficiency and repeatability. Induction hardening produces a hard martensitic layer on the specimen surface, which is accompanied by the generation of compressive residual stresses in the hardened case and tensile stresses in the untreated core. Residual stresses generated by induction hardening greatly imp

Effect of electrolytes on the sol–gel phase transitions in a Pluronic F127/carboxymethyl cellulose aqueous system : Phase map, rheology and NMR self-diffusion study

This investigation aims to obtain a thermosensitive platform useful for specific nanomedicine applications through the addition of suitable salts. An aqueous mixture consisting of the copolymer Pluronic F127 and sodium carboxymethyl-cellulose, in a ratio of 20/4 by weight, in the presence of different concentrations of Na2SO4, NaCl, and NaSCN, was investigated using the visual inversion tube appro

A Phase 2 Trial of the Effect of Antiandrogen Therapy on COVID-19 Outcome : No Evidence of Benefit, Supported by Epidemiology and In Vitro Data

Background: Men are more severely affected by COVID-19. Testosterone may influence SARS-CoV-2 infection and the immune response. Objective: To clinically, epidemiologically, and experimentally evaluate the effect of antiandrogens on SARS-CoV-2 infection. Designs, settings, and participants: A randomized phase 2 clinical trial (COVIDENZA) enrolled 42 hospitalized COVID-19 patients before safety eva

Multi-modal characterization of kesterite thin-film solar cells : experimental results and numerical interpretation

We report a multi-modal study of the electrical, chemical and structural properties of a kesterite thin-film solar cell by combining the spatially-resolved X-ray beam induced current and fluorescence imaging techniques for the evaluation of a fully functional device on a cross-section. The data allowed the correlation of the chemical composition, defects at interfaces and inhomogeneous deposition

Tolerance of metal halide perovskites to mechanical treatment enables the fabrication of patterned luminescence nano- and microstructures

Metal halide perovskites have shown a great performance in a broad range of optoelectronic devices. The variety of preparation methods makes perovskites especially attractive, yet preparation of complex nanostructures based on these materials remains challenging. Here we present a template assisted method allowing to achieve any pre-designed arrangement of methylammonium lead triiodide (MAPbI3) po

When attentional and politeness demands clash : The case of mutual gaze avoidance and chin pointing in Quiahije Chatino

Pointing with the chin is a practice attested worldwide: it is an effective and highly recognizable device for re-orienting the attention of the addressee. For the chin point to be observed, the addressee must attend carefully to the movements of the sender’s head. This demand comes into conflict with the politeness norms of many cultures, since these often require conversationalists to avoid meet

Yangon Stories

Since the colonial period spatial violence has been a regular occurrence for people throughout Yangon (Rangoon). These acts, led by successive state powers have only increased. Since 2021, the scale of these violences are unprecedented and country wide displaying raw brutality exerted by the junta.Yangon Stories is a collaborative research project aimed at documenting and bearing witness to the sp

Genome-wide association study of REM sleep behavior disorder identifies polygenic risk and brain expression effects

Rapid-eye movement (REM) sleep behavior disorder (RBD), enactment of dreams during REM sleep, is an early clinical symptom of alpha-synucleinopathies and defines a more severe subtype. The genetic background of RBD and its underlying mechanisms are not well understood. Here, we perform a genome-wide association study of RBD, identifying five RBD risk loci near SNCA, GBA, TMEM175, INPP5F, and SCARB

Find the Bad Apples: An efficient method for perfectkey recovery under imperfect SCA oracles– A case study of Kyber

Side-channel resilience is a crucial feature when assessing whether a postquantum cryptographic proposal is sufficiently mature to be deployed. In this paper, we propose a generic and efficient adaptive approach to improve the sample complexity (i.e., the required number of traces) of plaintext-checking (PC) oracle-based sidechannel attacks (SCAs), a major class of key recovery chosen-ciphertext S

Electroconvulsive therapy in children and adolescents : results from a population‑based study utilising the Swedish National Quality Register

Electroconvulsive therapy (ECT) is effective and safe for adults with severe depression, but less studied in adolescents. Here, we examined the indications, prevalence, practice, response and remission rates, and side effects in young people treated with ECT in Sweden. We also examined the usage of ECT in the transition to adult psychiatry. Using data from national patient registers and the Swedis

Production and characterization of novel anti-prostate-specific antigen (PSA) monoclonal antibodies that do not detect internally cleaved Lys145-Lys146 inactive PSA

Background: The nature of free, uncomplexed prostate-specific antigen (s) in the circulation is still unknown. In this study, we developed novel anti-PSA antibodies using PSA produced by a metastasized cancer cell line, LNCaP, as an immunogen. Methods: Hybridoma cell lines were screened with different methods that aimed at finding antibodies specific for the forms of free PSA produced by LNCaP cel

Free, Complexed and Total Serum Prostate Specific Antigen : The Establishment of Appropriate Reference Ranges for their Concentrations and Ratios

Purpose: Prostate specific antigen (PSA) exists in the serum in several molecular forms that can be measured by immunodetectable assays: free PSA, PSA complexed to alpha 1-antichymotrypsin (complexed PSA) and total PSA, which represents the sum of the free and complexed forms. We determined the normal distribution of values and established the appropriate reference ranges for these 3 molecular for

Streptavidin-polyvinylamine conjugates labeled with a europium chelate : Applications in immunoassay, immunohistochemistry, and microarrays

Background: The favorable properties of lanthanide chelates compared with conventional fluorescent probes have attracted considerable interest. A Eu3+ chelator, 4,7-bis(chlorosulfophenyl)-1,10-phenanthroline-2,9-dicarboxylic acid (BCPDA), has been synthesized previously. Methods: We here describe immunoassay, immunohistochemistry, and microarray applications of a new streptavidin-based universal p

Europium-labeled oligonucleotides to detect point mutations : Application to PI Z α1-antitrypsin deficiency

We describe a novel assay for detection of point mutations. The method combines the specificity and sensitivity of the polymerase chain reaction (PCR) and allele-specific oligonucleotides (ASO) with highly sensitive time- resolved fluorometry. ASO probes differing by a single base substitution and labeled with europium (Eu) chelates were hybridized in solution simultaneously with a biotinylated ol

Species‐ and organ‐specificity of secretory proteins derived from human prostate and seminal vesicles

Polyclonal antibodies against semenogelin (SG) isolated from human seminal vesicle secretion and acid phosphatase (PAP), β‐microseminoprotein (β‐MSP), and Prostate‐Specific Antigen (PSA) derived from human prostatic fluid, as well as a monoclonal antibody against β‐MSP were used for immunocytochemical detection of the respective antigens in different organs from different species. SG immunoreactiv

Discrimination of prostate cancer from benign disease by selective measurements of serum subfractions of free PSA that are not internally cleaved at Lys145-Lys146

Background: The free PSA fraction in serum of patients with various prostatic disorders is essentially unreactive with the anti-proteases in blood. Recently reported data show that it is likely to consist of a mixture of proPSA, internally cleaved PSA forms, and possibly other uncharacterized forms. Currently there are no specific methods available to measure the different free PSA subfractions an

A balance between putting on the researcher’s hat and being a fellow human being : a researcher perspective on informal carer involvement in health and social care research

Public involvement in health and social care research is increasingly prioritized by policy-makers and research funders. Often, the impact of the involvement is described in terms of how it has contributed to the research outcomes and how it has affected the involved members of the public. There is a dearth of studies reporting from the perspective of researchers themselves of having involved memb

Jihadi Kitsch: The Promesse de Bonheur of Islamist Terrorism

Elaborating on conceptualizations of kitsch in the realm of art and sociology in the context of ISIS propaganda and culture, this article introduces the concept of jihadi kitsch. Kitsch is characterized by a compulsion to escape from the banality of daily reality and lack of coherent meaning in modern society through, in the words of the philosopher and sociologist Theodor Adorno, a self-made and Elaborating on conceptualizations of kitsch in the realm of art and sociology in the context of ISIS propaganda and culture, this article introduces the concept of jihadi kitsch. Kitsch is characterized by a compulsion to escape from the banality of daily reality and lack of coherent meaning in modern society through, in the words of the philosopher and sociologist Theodor Adorno, a self-made and