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SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase (dNTPase) that restricts viral replication in infected cells and limits the sensitivity to cytarabine by hydrolysing its active metabolite, as recently shown in acute myeloid leukemia. Cytarabine is an essential component in the Nordic mantle cell lymphoma protocols (MCL2 and MCL3) for induction and high-dose chemotherapy treatment befor
Currently, the coronavirus disease 2019 (COVID-19) severely influences physiotherapy education which is based mostly on face-to-face teaching. Thus, educators have been compelled to adapt their pedagogical approaches moving to digital education. In this commentary, we debate on digital education highlighting its effectiveness, the users’ perspectives, and its weakness in the context of physiothera
Aims/hypothesis: Galectin-1 modulates inflammation and angiogenesis, and cross-sectional studies indicate that galectin-1 may be a uniting factor between obesity, type 2 diabetes and kidney function. We examined whether circulating galectin-1 can predict incidence of chronic kidney disease (CKD) and type 2 diabetes in a middle-aged population, and if Mendelian randomisation (MR) can provide eviden
In platform software ecosystems, organizations partner and innovate together. Success and innovation depend on managing complex sets of business relationships and stakeholders and using a requirements-selection process. We describe the associated challenges and strategies from the study of two large proprietary platform ecosystems.
People can judge a stranger's trustworthiness at first glance solely based on facial appearance. Moreover, the trust behaviors people exhibit toward strangers differ depending on perceived trustworthiness from faces. Research has found that people have different risk preferences according to the gain or loss frame. Therefore, we hypothesized that the risk decisions are differently affected by faci
Early Christian heresiology is, like polemics in general, a genre that has commonly been negatively perceived in scholarship. There is an idea of heresiological texts as not only historically unreliable, but also unproductive, in contrast to the creative thinking that can be found in theological treatises. Considering the understanding of heresiology as reactive and exclusive, it is not surprising
Beamforming technology plays a significant role in source localization and quantification. As traditional delay-and-sum beamformers generally yield low spatial resolution, as well as suffer from the occurrence of spurious sources, different forms of deconvolution methods have been proposed in the literature. In this work, we propose two approaches based on a sparse reconstruction framework combine
This paper investigates the stabilization of underactuated vehicles moving in a three-dimensional vector space. The vehicle's model is established on the matrix Lie group SE(3), which describes the configuration of rigid bodies globally and uniquely. We focus on the kinematic model of the underactuated vehicle, which features an underactuation form that has no sway and heave velocity. To compensat
The usefulness of blood culture time-to-positivity (TTP) in the diagnosis of endovascular infections has previously been shown. Here, we investigated TTP in 41 patients with F. necrophorum bacteraemia and found an association between short TTP and Lemierre's syndrome (p = 0.026).
Background: There is an increasing interest in the potential health benefits of positive psychological states, especially with regard to cardiovascular health. Life satisfaction is thought to be a constituent component of psychological well-being; however, among the few previous studies that have investigated its associations with early stages of the cardiovascular disease process, only one small
Information Systems Interactions are a pivotal point in developing an understanding of a socio-technical system. From this perspective, Information Systems could be defined as the cooperation, coexistence and integration of a socio-technical approach with the social aspect. This research investigates how people communicate in a business and how this is likely to support knowledge sharing practices
Behind everything we do in our daily lives there is a reason for doing it. This paper looks into the motives behind DDoS attacks as a form of cyberattack along with attacker personas. This paper also investigates DDoS attacks technically and it is suggested that there is a need for a socio-technical approach to these attacks to investigate why they occur and the reasoning the attacker(s) could hav
Due to improved laboratory techniques, touched surfaces and items are increasingly employed as sources of forensic DNA evidence. This has urged a need to better understand the mechanisms of DNA transfer between individuals. Shedder status (i.e. the propensity to leave DNA behind) has been identified as one major factor regulating DNA transfer. It is known that some individuals tend to shed more DN
Purpose: Hypoxia (low oxygen) is a common feature of solid tumors that has been intensely studied for more than six decades. Here we review the importance of hypoxia to radiotherapy with a particular focus on the contribution of hypoxia to immune responses, metastatic potential and FLASH radiotherapy, active areas of research by leading women in the field. Conclusion: Although hypoxia-driven metas
PurposeThe aim of this study was to better understand the attitudes towards the use of technology to support chronic stroke survivors in a home-based setting.MethodsA quantitative study was used on the data obtained from a face to face survey with the sample group, incorporating quantitative statistical analysis.ResultsParticipants reported positive attitudes towards using technology for their own
This paper is about the socio-technical findings of a project that was carried out for an organisation in the educational sector. The main aim of the project was to explore the possibilities of developing a mobile Augmented Reality authoring tool that educators would use to create AR experiences in attempt to improve their teaching methods. A novel ‘solution’ was designed and prototyped, which ini
Sustainability is rarely implemented in employee work practices in small and medium-sized enterprises (SMEs). The authors note that SMEs should implement sustainability practices as integrated part of work activities to ensure long term success. This paper describes an empirical study of SMEs sustainability on employee real work practices. A relevant perspective is offered by the triple bottom lin
Background: Community services for Swedish people with intellectual disability (ID) are intended to support self-determination and integrity. Legislation does not allow the use of restrictive or coercive measures. Aim: The aim of this study is to identify the extent of, rationale for, and strategies staff believe would reduce the use of restrictive measures in group homes and daily activities serv
