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Temozolomide (TMZ) increases the overall survival of patients with glioblastoma (GBM), but its role in the clinical management of diffuse low-grade gliomas (LGG) is still being defined. DNA hypermethylation of the O (6) -methylguanine-DNA methyltransferase (MGMT) promoter is associated with an improved response to TMZ treatment, while inactivation of the DNA mismatch repair (MMR) pathway is associ
This study explored the informational needs of individuals attending genetic counseling for hereditary cancer, using a free-choice and a forced choice method. Prior to the consultation the informational needs of 334 counselees from Sweden and Norway were assessed by the QUOTE-gene (ca) questionnaire and by a study specific forced choice method, using Q-methodology. Questionnaire responses indicate
From the Wunderkammern of Renaissance Europe to the curated vaults of today’s natural history museums, millions of insect specimens have been preserved, capturing an irreplaceable chronicle of biodiversity, including lineages that are rare, highly specialized, or already extinct. Yet their fragility has historically constrained genomic inquiry. Here, we apply museomic methodology to a >40-year-old
How does coalition participation influence party membership? We argue that parties that take part in coalition governments are likely to experience less favorable party membership developments than parties governing alone because of the compromises they have to agree on in multi-party cabinets. This should be particularly likely for parties in ideologically diverse coalition governments since part
Alzheimer’s disease (AD) continues to pose a major global health challenge, with incidence rising sharply and current therapies offering only symptomatic relief. This study builds on prior work into six structurally diverse multi-target compounds (1–6) designed to modulate key pathological processes in AD. We have now combined experimental and computational approaches to determine a set of pharmac
Control of crystallographic texture is key to improving the properties of piezoelectric ceramics, but it has so far mainly been realized in the form of fiber textures perpendicular to the dominant surface of simple 2.5D structures. This work demonstrates how grains in piezoelectric ceramics can be aligned in complex patterns and shapes via material extrusion-based additive manufacturing, specifica
Precise mapping of structural heterogeneity at the sub-10 nm scale is pivotal for rational nanoparticle design, yet conventional analytical workflows remain inadequate. Here we integrate dilution-controlled asymmetric flow field-flow fractionation (AF4) with small-angle X-ray scattering (SAXS) and small-angle neutron scattering (SANS) to interrogate ellipsoidal solid–liquid lipid nanoparticles (LN
The activity and stability of an electrocatalyst is governed by the structural and chemical changes occurring at the solid–liquid interface. While single crystal electrodes have often served as model systems to elucidate structure–function relationships, extending these insights to more realistic polycrystalline electrodes requires experimental techniques with spatial resolution that can operate u
The Elites of Civil Society: A Comparative Analysis presents the first book-length analysis of the top echelons in civil society from an elite perspective. Combining elite studies with civil society research, the book analyses civil society elite structures in four countries – Italy, Poland, Sweden, and the UK. Using a theoretical framework focusing on the vertical stratification in the sector and
Background Early-onset depression contributes significantly to long-term disability and suicide, making high-quality healthcare for young people with depression a critical concern. Medical record review (MRR) is widely used to assess healthcare quality. However, its application to depression care for children and adolescents appears underexplored, with no consensus on conceptualising or measuring
Background: Over time, family structures have grown more complex, diversifying adult relationships. While research has compared marital, cohabiting and living apart together relationships based on quality and health, less is known about their sexual dynamics. Theoretical frameworks suggest that co-resident relationships may integrate sexuality differently from living apart together unions, where p
Recent observations from the James Webb Space Telescope have revealed unexpectedly luminous galaxies, exhibiting stellar masses and luminosities significantly higher than predicted by theoretical models at Cosmic Dawn. In this study, we present a suite of cosmological zoomed-in simulations targeting high-redshift (z ≥ 10) galaxies with dark matter halo masses in the range 1010-1011M⊙ at z = 10, us
We propose a method for estimating the 3D position of a target point, given multiple measurements of it, using mm-wave radar data. Given azimuth headings and range estimates from posed radar positions, we find the 3D position, using an approximate, but geometrically and statistically meaningful cost. The 3D position is found in an optimal way, using this approximate cost. By deriving the Lagrangia
