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Serine hydroxymethyltransferase (SHMT) is the major source of 1-carbon units required for nucleotide synthesis. Humans have cytosolic (SHMT1) and mitochondrial (SHMT2) isoforms, which are upregulated in numerous cancers, making the enzyme an attractive drug target. Here, we show that the antifolates lometrexol and pemetrexed are inhibitors of SHMT2 and solve the first SHMT2-antifolate structures.

Beslutsfattare bör inse betydelsen av butikers vara eller inte vara för samhällets utveckling innan det är för sent, skriver Karin M Ekström, professor i företagsekonomi, och Håkan Jönsson, docent i etnologi.

Occupational well-being is a central issue underpinning factors that constitute a good life. This study aimed to explore occupational well-being among Middle Eastern immigrants to Sweden, as reflected in the occupations performed in the context of psychosocial health care. Ten participants experiencing mental health issues, who received occupation-based rehabilitation, were interviewed. Grounded t

Determining the drivers of diversity is a major topic in biology. Due to its high level of micro-endemism in many taxa, Madagascar has been described as one of Earth's biodiversity hotspot. The exceptional Malagasy biodiversity has been shown to be the result of various eco-evolutionary mechanisms that have taken place on this large island since its isolation from other landmasses. Extensive phylo

There is a scarcity of instruments for assessing opportunities for residentswith psychiatric disabilities to engage in meaningful home-based activities.We thus developed the Perceived Meaning of Activity in Housing (PMA-H),containing four subscales (activity opportunities, social interaction, developingas a person, and organization and planning). The aim of the study was to investigate the content

This study investigates the impact of beach sediment supply on dune volume evolution through data analysis and model simulations of the Kennemer dunes in the Netherlands. A cross-shore sediment transport model (the CS-model) is applied with local time-averaged longshore sediment transport gradients derived from bathymetric and topographic observations. The model is used to study the relative impor

A new palaeoecological and palaeoclimatic project in the subalpine Abisko area, N Scandes, founded upon the pollen zone system defined by Sonesson is described. This model of vegetation history has been confirmed, although the chronology is partly revised. Sonesson's pollen diagrams are combined with new results from a lake sediment sequence at the tree-limit, which include sedimentologic, mineral

The remit of the INTIMATE project of the INQUA Palaeoclimate Commission is to synthesise marine, terrestrial and ice-core data for the North Atlantic region during the Last Glacial-Interglacial Transition (LGIT: ca 13-1014C kyr BP; ca 15-11.5 ice-core kyr BP). A major problem, however, is the difficulty of effecting correlations at a temporal resolution that are adequate for defining 'leads' and '

This study investigates grain-size sorting through longshore transport processes and how it influences dune evolution.The analysis is based on a data set of 58 sediment samples distributed alongshore over a 6.5-km-long sandy beach in Ängelholm, Sweden. Grain size differs significantly from north to south, where median grain size varies from about 0.4–0.15 mm. The long-term coastal evolution is der

The Journal of Water Management and Research (Vatten) celebrates 2019 its 75th anniversary with a special issue, republishing one article per decade from 1940 to 2010. In the present article, we summarize the development of Swedish water research and management based upon the material published in the journal. We read all issues of the journal, noting important trends, percentage of female authors

Background: Warfarin-treated patients with a prolonged Prothrombin Time (PT) can have a normal rotational thromboelastometry (ROTEM) clotting time (CT). A previous in vitro study found that activated prothrombin complex concentrates (APCC) could reverse an albumin-induced coagulopathy monitored with ROTEM, but that prothrombin complex concentrates (PCC) could not. The aim of this study was to inveBackground: Warfarin-treated patients with a prolonged Prothrombin Time (PT) can have a normal rotational thromboelastometry (ROTEM) clotting time (CT). A previous in vitro study found that activated prothrombin complex concentrates (APCC) could reverse an albumin-induced coagulopathy monitored with ROTEM, but that prothrombin complex concentrates (PCC) could not. The aim of this study was to inve

One of the greatest challenges the world is facing is climate change. The need of reduction of energy use and an increased use of renewable energy in buildings constitutes important climate change mitigation measures.The objective of this research is to investigate methodologies and performance indicators for the evaluation of energy and moisture performance of buildings, including co-benefits whi

BACKGROUND: Antibacterial peptidyl derivative - Cystapep 1, was previously found to be active both against antibiotic-resistant staphylococci and streptococci as well as antibiotic-susceptible strains of these species. Therefore, it is a promising lead compound to search for new antimicrobial peptidomimetics.OBJECTIVES: We focused on identifying structural elements that are responsible for the bio