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Popular Abstract in Swedish Fibromodulin och dystrofin i ateroskleros; en populärvetenskaplig sammanfattning VAD ÄR ATEROSKLEROS? Ateroskleros – det man tidigare kallade för åderförkalkning – är grundorsaken till hjärtinfarkt, stroke och kärlkramp. Ett aterosklerosplack är en förträngning i ett blodkärl, ofta vid en förgrening där blodflödet är turbulent. Placket börjar ofta växa redan i unga år Cardiovascular disease represents nearly half the cases of noncommunicable diseases worldwide and is the leading global cause of death. The main underlying cause is atherosclerosis, and in atherosclerotic plaque progression the structure, composition and integrity of a dynamic extracellular matrix (ECM) is one very important factor. This thesis discusses the importance of the connection between th

In this study, numerical simulations are conducted to investigate the effects of bowed outlet guide vanes (OGVs) on endwall heat transfer and aerodynamic performance. Both on- and off-design conditions are studied. For bowed vanes, the bowed angle varies from 10 degrees to 40 degrees and the normalized bowed height ranges from 0.1 to 0.3. Results are included for Nusselt number distributions on th

Fresh water availability and demand are unevenly distributed both temporally and geographically. Furthermore, the availability of fresh water has remained more or less constant, while the demand for clean water is steadily increasing. With demand surpassing supply, an integrated water resource management approach is required to ensure even distribution of potable water to all levels of society whi

T cells are key cellular components of the adaptive immune system that play a critical role in our defense against pathogens and cancer but also contribute to pathology in the setting of chronic inflammation and autoimmunity. The thymus constitutes the body's major T cell production site, where bone marrow-derived progenitors migrate in a co-ordinated fashion through anatomically distinct cortical

Implementation of sustainability criteria, both in legal frameworks and voluntary sustainability standards, is an urgent and important issue. In the article, three less state-centric governance approaches and their capacity to be used to implement sustainability criteria have been investigated. The chosen approaches are good governance, multi-level governance and selfgovernance. Their potential st

Two single nucleotide polymorphisms (SNPs), rs4415084, and rs10941679 on chromosome 5p12 were associated with risk of breast cancer in a recent genome-wide association study (GWAS) of women of European ancestry. Both SNPs are located in a large high-LD region and the causal variant(s) are still unknown. We conducted a nested case-control study in a cohort of African American women to replicate and

Stroke genetics includes several topics of clinical interest, including (1) molecular genetic variations affecting risk of monogenic stroke syndromes; (2) molecular genetic variations affecting risk of common stroke syndromes, sometimes with specific effects on risk of specific main types of stroke or subtypes of ischemic and hemorrhagic stroke; (3) genetics of conditions associated with stroke ri

The study investigated 2 aspects of the accuracy (i.e., realism) of confidence judgments of persons age 60-93 years (N = 1,384) regarding their answers to general knowledge questions. These aspects are the level of confidence (calibration) in relation to the proportion of correct answers and the ability to discriminate between correct and incorrect answers by means of confidence judgments. No age

Real-time rendering is increasingly being performed on battery powered devices, such as laptops and mobile phones. As a result, performance in rendering time is not the only important factor, but the energy consumption is also becoming more and more important, as a lower energy usage directly translates to longer battery time. The main topic of this thesis is energy consumption of graphics process

BACKGROUNDQuinoa is a pseudo-cereal grown predominantly in South America. The quinoa stalks are lignocellulosic residues, which have a limited use today. The objective of the current study was to assess the potential of this material as a source of monosaccharides for fermentation purposes by means of steam pretreatment giving sugars from the hemicellulose part, and enzymatic hydrolysis of the sol

When developing software platforms for product lines, decisions on which features to implement are affected by factors such as changing markets and evolving technologies. Effective scoping thus requires continuous assessment of how changes in the domain impact scoping decisions. Decisions may have to be changed as circumstances change, resulting in a dynamic evolution of the scope of software asse

Farming environment and environmental exposure to microbial agents have been suggested to promote favorable development of immune system in children and protect against allergic diseases. However, effects of farm exposure on adult immune responses are less clear. Aim of the present study was to examine associations of farm related factors and measured microbial exposure with stimulated production

A traffic encounter between individual road users is a process of continuous interplay over time and space and may be seen as an elementary event with the potential to develop into an accident. This paper proposes a framework for organising all traffic encounters into a severity hierarchy based on some operational severity measure. A severity hierarchy provides a description of the safety situatio

Cash Flow-at-Risk (CFaR) is a risk measure that conveys information on the shortfall in cash flow, associated with a certain probability, a firm could experience over a certain time period. However, to provide information on outcomes that are identified as costly by the risk management literature, in particular underinvestment due to financing constraints, a risk measure needs to make explicit ref

Blood lead concentration (B-Pb), the main biomarker of lead exposure and risk, is curvi-linearily related to exposure. We assessed plasma lead (P-Pb) as a marker for both lead exposure and toxic effects. We examined claims that delta-aminolevulinic acid dehydratase genotype (ALAD) can modify lead toxicity. In 290 lead-exposed and 91 unexposed Chinese workers, we determined P-Pb, B-Pb, urinary lead