The aim of this thesis was to investigate the interactions between the kallikrein-kinin system (KKS) and the complement system during vascular inflammation and the contribution of extracellular vesicles (EVs). Vasculitis, in patients and in experimental models, was studied as a prototype inflammatory disease of the vasculature.Papers I and II addressed the impact KKS signalling has on complement a

2-amino-2-methyl-1-propanol (AMP) in dimethyl sulfoxide (DMSO) is a precipitating non-aqueous amine technology that can potentially lower the energy demand during CO2 removal from industrial flue gases compared to aqueous amine technologies. However, DMSO is hygroscopic and has a high possibility of absorbing water from humid flue gases, which can affect the physical properties of the system,

This study investigates city dynamics employing a nonextensive diffusion equation suited for addressing diffusion within a fractal medium, where the nonadditive parameter, q, plays a relevant role. The findings demonstrate the efficacy of this approach in determining the relation between the fractal dimension of the city, the allometric exponent and q, and elucidating the stationary phase of urban

Background: Levodopa–entacapone–carbidopa intestinal gel (LECIG) was introduced on the Swedish market in 2019. The therapy is aimed at patients with Parkinson's disease (PD) with fluctuations and dyskinesias. Long-term efficacy and safety data are lacking. Objective: To investigate the efficacy, tolerability, and safety of LECIG in regular clinical practice for Parkinson's disease in Sweden. Metho

Sound is a valuable cue in the marine environment that can inform animals about habitat location and community composition. Indeed, sound is often used for orientation and navigation by larval reef fishes during settlement. However, despite sound’s role in the early life of reef fishes, whether post-settlement reef fishes use ambient soundscapes to inform their movement decisions remains less clea

PURPOSE OF REVIEW: Small cell lung cancer (SCLC) is an aggressive disease with a poor prognosis, whereas its metastatic capacity carries a predilection for the brain. Although prophylactic cranial irradiation (PCI) has been used to address this problem, upcoming alternatives might necessitate reflection of its application in SCLC treatment. RECENT FINDINGS: The addition of immunotherapy to treatme

There are some evidences that hypogammaglobulinemia in newly diagnosed diffuse large B cell lymphoma (DLBCL) is a predictor for inferior outcome, but the risk for infection-related admissions specifically related to hypogammaglobulinemia is not known. The aim was to explore if hypogammaglobulinemia in untreated DLBCL in a Swedish cohort was associated with inferior outcome, and to assess the relat

The efficiency of ultrafiltration (UF) of acidified skim milk (SM) is impaired by protein aggregation and mineral scaling. The aim of this study is to assess the potential of acidification by electrodialysis with bipolar membranes (EDBM), in comparison with citric acid (CA), prior to the UF process on filtration performance, fouling and composition of the protein concentrates. Electro-acidificatio

The annexation of Crimea, the subsequent insurgency of Russian-backed separatists in the Donbas region of Ukraine in 2014 and the current full-scale Russian invasion of Ukraine have led to different responses from political elites, diasporas and migrants currently residing in different European countries. The historic decision of Sweden to send defence weapons to Ukraine as well as to apply for NA

Coacervates of oppositely charged milk proteins are used in functional food development, mainly to encapsulate bioactives. To uncover the driving forces behind coacervates formation, we study the association of lactoferrin and β−lactoglobulin at amino-acid level detail, using molecular simulations. Our findings show that inter-protein electrostatic interactions dominate and are, surprisingly, equa

The aim of this article is to understand how a group of subsidised employees constructed a collective identity and symbolic community, and the role the municipal labour market programme played in that process. Further, it explores whether and how a shared collective identity and symbolic community may provide an explanation for how the ‘successful intervention/lock-in effect paradox’ occurs when u

BACKGROUND: Although death in old age is unavoidable, premature death-defined here as death before age 70 years-is not. To assess whether halving premature mortality by 2050 is feasible, we examined the large variation in premature death rates before age 70 years and trends over the past 50 years (1970-2019), covering ten world regions and the 30 most-populous nations. This analysis was undertaken

Though child anthropometric failure (CAF) is a persistent problem in India, previous studies have often neglected state-level variance and aggregated moderate and severe CAF categories. This study addresses this gap by examining moderate and severe malnutrition across India's states and union territories (UTs) from 1993 to 2021. Data of children under 2 years old from five waves of National Family

This chapter provides a brief yet comprehensive overview of the state-of-the-art in semiconductor characterization using spectroscopic ellipsometry. The concept of ellipsometry as optical technique to determine the state of polarization of light reflected or transmitted from complex-structured and multiple layered semiconductor materials is introduced and laid out in the framework of the Jones vec

This article examines the debate surrounding an ice hockey museum in Örnsköldsvik, Sweden. In 2013, the local ice hockey club, Modo Hockey, received a loan from Örnsköldsvik municipality to build an ice hockey museum in its home arena. The ice hockey museum was a part of a bigger heritage project that involved various sites in the area around Örnsköldsvik, with the intention of increasing the numb