The enoyl-acyl carrier protein (ACP) reductase (ENR) is a key enzyme within the bacterial fatty-acid synthesis pathway. It has been demonstrated that small-molecule inhibitors carrying the diphenylether (DPE) scaffold bear a great potential for the development of highly specific and effective drugs against this enzyme class. Interestingly, different substitution patterns of the DPE scaffold have b

Type 2 Innate lymphoid cells (ILC2s) are implicated in helminth infections and asthma where they play a role in the production of Th2-type cytokines. ILC2s express the IL-33 receptor and are a major cell type thought to mediate the effects of this cytokine in vivo. To study the signalling pathways that mediate IL-33 induced cytokine production, a culture system was set up to obtain pure population

Clinical trials show that tyrosine kinase inhibitor (TKI) treatment can be discontinued in selected patients with chronic myeloid leukaemia (CML). Although updated CML guidelines support such procedure in clinical routine, data on TKI stopping outside clinical trials are limited. In this retrospective study utilising the Swedish CML registry, we examined TKI discontinuation in a population-based s

The atmospheres of close-in planets are strongly influenced by mass loss driven by the high-energy (X-ray and extreme ultraviolet, EUV) irradiation of the host star, particularly during the early stages of evolution. We recently developed a framework to exploit this connection and enable us to recover the past evolution of the stellar high-energy emission from the present-day properties of its pla

Sanfilippo syndrome type C (mucopolysaccharidosis IIIC) is an early-onset neurodegenerative lysosomal storage disorder, which is currently untreatable. The vast majority of studies focusing on disease mechanisms of Sanfilippo syndrome were performed on non-neural cells or mouse models, which present obvious limitations. Induced pluripotent stem cells (iPSCs) are an efficient way to model human dis

This study looks at the effect of losing a parent before the age of 16 on adult income, educational attainment, and health. Using detailed data from the Swedish registers and several methodological strategies, we follow to adulthood individuals born between 1968 and 1981 and observe their later-life outcomes.The results suggest that, in line with previous research, losing a parent during childhood

Context. Positions and proper motions of Gaia sources are expressed in a reference frame that ideally should be non-rotating relative to distant extragalactic objects, coincident with the International Celestial Reference System (ICRS), and consistent across all magnitudes. For sources fainter than 16th magnitude, this is achieved through Gaia's direct observations of quasars. At brighter magnitud

The high rate of disability pensioners is alarming in many industrial countries today. In Sweden the rate was 9.5% of the population aged 16-54 years in March 2005. Through new legislation, which came into force 2000, disability pensioners in Sweden are able to go back to work without jeopardising their benefit. This 'resting disability pension' was used by 0.2% of all disability pensioners in SweThe high rate of disability pensioners is alarming in many industrial countries today. In Sweden the rate was 9.5% of the population aged 16-54 years in March 2005. Through new legislation, which came into force 2000, disability pensioners in Sweden are able to go back to work without jeopardising their benefit. This 'resting disability pension' was used by 0.2% of all disability pensioners in Swe

Estimating age distributions, or star formation histories, of stellar populations in the Milky Way is important in order to study the evolution of trends in elemental abundances and kinematics. We build on previous work to develop an algorithm for estimating the age-metallicity distribution which uses the full age-metallicity probability density functions (PDFs) of individual stars. No assumptions

Närsjukvård är ett centralt begrepp i ett förändringsarbete som för genomförs i nordöstra Skåne för att utveckla hälso- och sjukvårdsväsendet. Det ingår därmed som en av de centrala delarna av Region Skånes vision om hälso- och sjukvård: Skånsk livskraft – vård och hälsa. Syftet med denna rapport är att ge en bakgrund till begreppet (Del A) och att presentera en del preliminära rön beträffande hur

The dynamic response of blocks sitting on a half-space is considered. Buildings and other structures placed on or within the ground influence the transmission of seismic waves. Hence, the presence of a building will have an impact on the dynamic response of neighbouring buildings. Furthermore, obstacles such as concrete blocks lead to wave scattering that may be beneficial or unfavourable for the