Hypothesis: Sponge phase (L3) lipid nanoparticles (L3-NPs) have been shown to have large potential for the encapsulation of biomolecules, such as enzymes, with applications in food and pharmaceutical science. In this study, we introduce new formulations of L3-NPs including the phospholipids dioleoylphosphatidylcholine (DOPC) and dioleoyltrimethylammonium propane (DOTAP). The interaction of these n

Drug resistance remains a critical challenge in cancer chemotherapy, particularly in oral squamous cell carcinoma (OSCC). Recent findings have highlighted the significant roles that autophagy and extracellular vesicles (EVs) play in contributing to chemoresistance. In previous studies, we demonstrated that EVs are essential in mediating cisplatin resistance in human OSCC cells. In this study, we s

Chlorophyll-a (Chl-a) is one of the critical water quality indicators that shows the eutrophication status of aquatic ecosystems. As the largest lake and a well-known attraction in middle Europe, Lake Balaton contributes 70 % or more of local economy through tourism, while also maintaining a unique biodiversity. Therefore, long-term monitoring of water quality is essential for its effective manage

Background: The response to the COVID-19 pandemic involved various lockdown measures, including school closures, which significantly impacted young populations, particularly in low-and middle-income countries (LMICs). Given the well-known protective effect of regular school attendance on sexual and reproductive health and rights (SRHR), reports of disrupted education, compromised SRHR, and an incr

Background: Multimorbidity is increasing globally, affecting over one-third of the population. Adults with complex needs often experience physical, mental, and cognitive disorders, leading to increased healthcare utilization, reduced quality of life, and social challenges. The frequent co-occurrence of psychiatric conditions, substance abuse, addiction, and homelessness highlights the complexity o

Parkinson’s disease (PD) is a complex neurodegenerative disease with a largely unknown etiology. Although the loss of dopaminergic neurons in the substantia nigra pars compacta is the pathological hallmark of PD, neuroinflammation also plays a fundamental role in PD pathology. We have previously reported that PD patients have increased frequencies of T cells reactive to peptides from α-synuclein (

This thesis explores what motivates female cadets to remain in the Swedish Armed Forces, and how they navigate their gendered positionalities within this male-dominated organisation. As previous research on women in the military shows many women leave due to sexual harassment and other gendered challenges, this research aims to find out why some choose to stay. Based on eight semi-structured inter

This thesis explores the representations of homelessness by the not-for-profit association Emmaüs in France through the lens of deservingness and the impact of social control of the French government on these representations. The representation of homelessness is an important issue as Emmaüs uses this representation to determine the scope of its services and the deservingness of the homeless they

Social housing in Ireland has undergone several phases of transformation, including financial restructuring in the 1980s and severe retrenchment during the years of post-crash austerity. Concurrently, the overall housing sector has been defined by several ‘boom and bust’ crisis phases and is currently experiencing a housing crisis characterised by increasingly inflated property and rental prices,

Selective inheritance of sub-cellular components has emerged as a mechanism guiding stem cell fate after asymmetric cell divisions. Peroxisomes play a crucial role in multiple metabolic processes such as fatty acid metabolism and reactive oxygen species detoxification, but the apportioning of peroxisomes during stem cell division remains understudied. Here, we develop a mouse model and labeling te

Stress granules (SGs) are membraneless organelles formed in the cellular cytoplasm under stressful conditions through liquid–liquid phase separation (LLPS). SG assembly can be both dependent and independent of the eIF2α pathway, whereas cellular protein quality control systems mediate SG disassembly. Chaperones and specific domains of RNA-binding proteins strongly contribute to the regulation SG d

Purpose: Abdominal wall complications can be reduced by adhering to guidelines for midline laparotomy closure. However, implementation of guidelines can be challenging. To address this issue, a laparotomy closure device for swift and standardized abdominal closure was developed. The study evaluated the quality of the suture, safety, and speed of the device in a clinical setting. Methods: A prospec

Background: Both aging and Alzheimer's disease (AD) affect brain networks, with early disruptions occurring in regions involved in episodic memory. Few studies have, however, focused on distinguishing region-specific effects of AD-biomarker negative “normal” aging and early amyloid- and tau pathology on functional connectivity. Further, longitudinal studies combining imaging, biomarkers, and cogni

Bladder cancer (BLCA) and diabetes mellitus (DM) are two prevalent diseases that may share molecular mechanisms, suggesting potential links between metabolic disorders and cancer. Using bioinformatics approaches, we integrated multiple databases to identify common genes between BLCA and DM, screening for potential biomarkers. CXCL12 (C-X-C motif chemokine 12, also known as stromal cell-derived fac

Background: Home care underwent abrupt adaptations to handle the COVID-19 pandemic including an accelerated digitalization. While some research exists regarding the working conditions for home care personnel during the COVID-19 pandemic, few studies exist on the effect of everyday technology use in home care during the pandemic. The aim of this study was to investigate how digital technologies, in

Background: Cataracts are the leading cause of reversible blindness globally, disproportionately affecting populations in low- and middle-income countries. In Ethiopia, cataracts remain a significant public health concern. Despite the effectiveness of cataract surgery in restoring vision, information on recovery time and its predictors remain limited. The aim of this study was to assess time to re

The Multipole Injection Kicker (MIK) installed in the 3 GeV ring of MAX IV, is a success story in the use of a non-linear field device ensuring an almost transparent injection into the first ever built fourth-generation storage ring. Reducing the transient stored beam perturbations during top-up injections is particularly relevant for such machines operating at emittances in the regime of few hund

Background: Children aged 0–18 years who need long-term respiratory support rely on medical technology and comprehensive medical care. For this care to be provided at home, access to medical and social support and care is essential. In Sweden, the most notable form is personal care assistance (PCA), which is granted based on legislation and individual authority decisions. We aim to explore the imp

What happens when open, informal spaces disappear – and specifically, what happens when these spaces disappear in a city that used to be full of them? My project is rooted in two things. The first is the highly debated ”Amazon Tower” in Friedrichshain, and the polarized urban conditions around it. The second is my love for Berlin. Berlin has always been a city in flux. However, the latest round

Projektet växte fram ur en önskan att främja en livsstil mer i samklang med livet utomhus. Det resulterade i en undersökande gestaltning kring hur arkitekturen kan bredda begreppet för vad en bostad är – och bör vara – för att främja livskvalitet. Istället för att betrakta bostaden som en plats som tar slut vid ytterväggarna, föreställer jag mig hemmet som en förlängning av den värme och ljus som