Assessing synthetized molecules as potential inhibitors to PARP14 - Prospects of new chemosensitizers
Poly (ADP-Ribose) Polymerase 14 (PARP14) is an ADP-ribosyltransferase, an enzyme whose catalytic activity is to transfer ADP ribose (ADPr) to a target molecule, utilizing its substrate NAD+. PARP14 has been discovered to partake in the development of different kinds of cancers such as multiple myeloma, B-cell lymphoma and sarcoma, which has led to the interest of using PARP14 as a drug target for