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Cellular stress contributes to the capacity of melanoma cells to undergo phenotype switching into highly migratory and drug tolerant dedifferentiated states. Such dedifferentiated melanoma cell states are marked by loss of melanocyte specific gene expression and increase of mesenchymal markers. Two crucial transcription factors, MITF and SOX10, important in melanoma development and progression hav
Mental health disorders are usually gendered, with more women being diagnosed with depression for example. This elicits guidelines on how to diagnose mental health according to symptoms common to women, which in turn normalises those practices. This creates legal norms which are reflected when screening for such conditions; however, they require scrutiny, especially as they become formalised in or
STUDY DESIGN: A cross-sectional study based on an online questionnaire.OBJECTIVE: To investigate the prevalence and intensity of low back pain (LBP) in people with lower limb amputation (LLA) and to analyse the association factors that can influence the genesis of LBP.SUMMARY OF BACKGROUND DATA: It is still unclear whether LBP is more prevalent in the amputated population than in its non-amputated
In this paper, we propose a new minimal and a non-minimal solver for estimating the relative camera pose together with the unknown focal length of the second camera. This configuration has a number of practical benefits, e.g., when processing large-scale datasets. Moreover, it is resistant to the typical degenerate cases of the traditional six-point algorithm. The minimal solver requires four poin
When capturing panoramas, people tend to align their cameras with the vertical axis, i.e., the direction of gravity. Moreover, modern devices, e.g. smartphones and tablets, are equipped with an IMU (Inertial Measurement Unit) that can measure the gravity vector accurately. Using this prior, the y-axes of the cameras can be aligned or assumed to be already aligned, reducing the relative orientation
Background and objectivesEnergy use behaviour is a complex issue and multiple perspectives are needed to fully understand it. It is difficult to define the most effective strategies or behaviours that reduce energy use in residential environment (Casado et al., 2015) despite efforts put on energy-efficient design and technologies. This study focuses on cognitive processes on electricity use behavi
The article explores how the global Cold War conflict was made sense of and situated in local political, cultural and physical landscapes and communities during the 1980s in Britain and Denmark. Using civil defence as a prism, the article employs a comparative approach to explore variations within and between countries of how local authorities prepared or resisted the prospect of nuclear war. The
