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ABP 959 is a biosimilar to the eculizumab reference product (RP), which is approved for the treatment of patients with paroxysmal nocturnal hemoglobinuria (PNH). This multicenter, randomized, double-blind, active-controlled, two-period crossover study randomized eculizumab RP-treated patients with PNH to one of two treatment sequences (ABP 959/eculizumab RP or eculizumab RP/ABP 959) to evaluate th

This paper examines the role of policy in China’s digital and green (twin) transition, building on a qualitative study of a large corpus of policy documents in green and digital domains. We analyse the multi-level governance of these transitions for three regional case studies: Shanghai, Wuhan and Hangzhou. We find that regions both adopt and adjust green and digital aims and means differently fro

Background: In attention-deficit/hyperactivity disorder (ADHD), poor inhibitory control is one of the main characteristics, with oculomotor inhibition impairments being considered a potential biomarker of the disorder. While auditory white noise has demonstrated the ability to enhance working memory in this group, visual white noise is still unexplored and so are the effects of both types of white

Many industries approach AM as a direct replacement for conventional manufacturing technologies. This approach, however, does not fully utilize the unique possibilities that additive processes offer.

The Particle Finite Element Method (PFEM) is attractive for the simulation of large deformation problems, e.g. in free-surface fluid flows, fluid–structure interaction and in solid mechanics for geotechnical engineering and production processes. During cutting, forming or melting of metal, quasi-incompressible material behaviour is often considered. To circumvent the associated volumetric locking

Climate change poses significant challenges to the tourism industry, making understanding the factors influencing businesses’ adaptive responses crucial. This research investigates the complex interplay of social discourse, belief systems, perceived costs, risk perceptions, response efficacy, and self-efficacy in shaping tourism professionals’ adaptive and maladaptive behaviors. Focusing on busine

Certain oxygenated compounds, called oxygenates, when blended with gasoline, have the ability to inhibit the occurrence of engine knock, thus helping improve spark-ignition engine efficiency. Similarly, oxygenates can also be added to diesel fuel to decrease the exhaust emissions—soot in particular—from diesel engines. Although ethanol and biodiesel have had widespread use as oxygenates for gasoli

Context: Medications may become inappropriate for patients in the last phase of life and may even compromise their quality of life. Objective: To find consensus on recommendations regarding deprescribing of medications for adult patients with a life expectancy of six months or less. Methods: Experts working in palliative care or other relevant disciplines were asked to participate in this internat

This study investigates the combustion characteristics of ammonia and diesel sprays in a constant-volume vessel under conditions typical of internal combustion engines, focusing on the interplay between evaporation dynamics and flame interactions within the framework of the Direct Dual Fuel Stratification (DDFS) concept. Under non-evaporation conditions, ammonia and diesel sprays exhibit comparabl

This volume celebrates the 50th anniversary of the Universal Declaration of Human Rights (UDHR). In so doing, it offers a comprehensive and systematic treatment of the rights and duties contained in the UDHR, in the light of its history, the intentions of its drafters ant the standard-setting activities and monitoring efforts which have grown out of its existence. Each article of the UDHR is treat

Post-marketing reports of suspected adverse drug reactions are important for establishing the safety profile of a medicinal product. However, a high influx of reports poses a challenge for regulatory authorities as a delay in identification of previously unknown adverse drug reactions can potentially be harmful to patients. In this study, we use natural language processing (NLP) to predict whether

In many places, social movements and organised networks are the primary drivers of mobilisation for food sovereignty. Elsewhere, the concept has been institutionalized and incorporated into national food policy frameworks. However, there is a dearth of knowledge regarding places where food sovereignty efforts are spearheaded by NGOised civil society. This study addresses this gap by examining five

The rapid development of wearable biomedical systems now enables real-time monitoring of electroencephalography (EEG) signals. Acquisition of these signals relies on electrodes. These systems must meet the design challenge of selecting an optimal set of electrodes that balances performance and usability constraints. The search for the optimal subset of electrodes from a larger set is a problem wit

BackgroundTranscatheter aortic valve implantation (TAVI) is a percutaneous catheter-based treatment of aortic stenosis as an alternative to open heart valve surgery. In cases of TAVI endocarditis, the treatment possibilities may be limited as surgical removal of the infected valve may be associated with a high risk in elderly, comorbid or frail patients. The propensity of bacteria to form a biofil

This thesis is dedicated to the construction of a novel model for nuclear structure; aimed atheavy and super-heavy nuclei. The model builds upon, and extends, nuclear density functionaltheory. The model describes a mapping of an energy density functional into an effectiveHamiltonian which is postulated to have a simple form. This Hamiltonian is solved in theframeworks of the generator coordinate m

Hållbarhet och hållbar mobilitet har blivit viktiga mål i national politik och policy. Cykling har dock inte kunnat dra nytta av detta. Om man betraktar cyklingens betydelse under de senaste decennierna, och dess förväntade betydelse i framtiden, finns emellertid få anledningar till optimism, åtminstone inte på nationell och övergripande nivå; cykeln befinner sig fortfarande i skuggan av bilen. DeSustainability and sustainable mobility have become important political goals and have left their mark as important discourses in national policies and programs. Against expectations, cycling has barely benefited from this. Looking back over the shoulder at the significance of cycling over the last few decades and looking forward to suggested implications in the future give no reason for joy, at l

This paper investigates the causal effects of sovereign debt crises in a sample of 50 defaulting economies between 1870 and 2010. As default is potentially endogenous, we use the narrative approach to identify plausibly exogenous episodes. We find economically and statistically significant costs of up to 3.2% of GDP before recovering to the pre-crisis level after five years. The average aftermath,