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Cell adhesion is tightly regulated by specific molecular interactions and detachment from the extracellular matrix modifies proliferation and survival. HAMLET (Human Alpha-lactalbumin Made LEthal to Tumor cells) is a protein-lipid complex with tumoricidal activity that also triggers tumor cell detachment in vitro and in vivo, suggesting that molecular interactions defining detachment are perturbed
We have performed a quantitative structure determination of the (root 5 x root 5) R27 degrees surface oxide, formed on Pd(100) under semi-realistic conditions for catalytic CO oxidation, using in situ high-energy surface X-ray diffraction. We describe the experiment and the extraction of quantitative data in detail. The structural results are in agreement with previous reports of a system consisti
Clonal plants from poor habitats benefit less from morphologically plastic responses to heterogeneity than plants from more productive sites. In addition, physiological integration has been suggested to either increase or decrease the foraging efficiency of clonal plants. We tested the capacity for biomass production and morphological response in two closely related, rhizomatous species from habit
Popular Abstract in Swedish De fyra studier som ingår i denna avhandling är gjorda för att undersöka eventuella oönskade effekter av läkemedel på näthinnan. Näthinnan är en del av det centrala nervsystemet och känslig för toxiska substanser. För att skydda näthinnan så finns två barriärer – en yttre och en inre blod–näthinne- barriär. Dessa barriärer består av strukturer som håller samman celler iThe adverse effects of drugs in the eye are not easily detected, and the underlying pathogenesis not fully understood. The effects of four different kinds of drugs have been investigated in the rabbit eye, using electroretinography, ocular examination and histochemical methods. Rifabutin is a broad spectrum antibiotic with known ocular adverse effects (corneal opacities, uveitis and vascular ret
The cluster power is an important parameter for cluster-based wireless channel models. This paper addresses modeling and estimation of the cluster power for wireless channels. A novel way of estimating the cluster decay and cluster fading, where the effects of the noise floor is taken into account, is presented. Due to the noise floor present in the measurement, only a limited number of clusters a
Recent papers have proposed to design scheduling algorithms entirely as discrete-time controllers, i.e., to refrain from preserving the already installed scheduler, and replace it completely. At the cost of some system re-design impact, this new approach has been proved to yield significant advantages in terms of code size and simplicity, and above all to open the way to a system-theoretical analy
The presence of Fe-bound cyanide ligands in the active site of the proton-reducing enzymes [FeFe]-hydrogenases has led to the hypothesis that such Bronsted-Lowry bases could be protonated during the catalytic cycle, thus implying that hydrogen isocyanide (HNC) might have a relevant role in such crucial microbial metabolic paths. We present a hybrid quantum mechanical/molecular mechanical (QM/MM) s
Asymmetrical flow field-flow fractionation (AF4) is rapidly becoming a technique of choice for the separation and characterization of complex materials. It is capable of fractionating samples over a wide size (similar to 2 nm to 50 mu m in diameter) and molecular weight range (10(3)-10(10) g/mol). It offers gentle, low shear, low pressure separation conditions which are essential to preserve the s
This paper compares and contrasts the ethnographic practices of two non-native researchers – a Singaporean researcher studying families in mainland China and a Swedish researcher studying Chinese families in Singapore. A novel conceptual frame of ‘radius of observation positions’ has been proposed to explicate the extent of intrusion and intimacy to which researchers may venture in the private fam
The incidence of colorectal cancer (CRC) in young patients (≤50 years of age) appears to be increasing. However, their clinicopathological characteristics and survival are controversial. Likewise, the biomarkers are unclear. We used the West China (2008-2013, China), Surveillance, Epidemiology, and End Results program (1973-2011, United States) and Linköping Cancer (1972-2009, Sweden) databases to
III-V nanowires (NWs) are promising for a wide range of applications, ranging from optics to electronics, energy, and biological sensing. The structural quality of NWs is of paramount importance for the performance of such future NW-based devices. Random structural defects and polytypism occur naturally in semiconductor NWs, but progress both on the theoretical understanding and experimental contr
Finegoldia magna is a Gram-positive anaerobe and a member of the normal human microflora. This bacterium is also an opportunistic pathogen and isolated from ~10% of all anaerobic infections. Reoccurring taxonomical changes and the anaerobic growth have contributed to the neglect of F. magna. The present thesis describes the identification and characterization of two novel surface proteins of F. ma
We consider the implications of a model for long-duration gamma-ray bursts in which the progenitor is spun up in a close binary by tidal interactions with a massive black-hole companion. We investigate a sample of such binaries produced by a binary population synthesis, and show that the model predicts several common features in the accretion on to the newly formed black hole. In all cases, the ac
We describe herein an adsorption-induced energy transfer between phenanthrene, a major environmental pollutant, and a fluorescently labeled dendrimer acting as a host molecule. We find experimentally that such energy transfer is the most efficient at a solvent pH of 8 and for a phenanthrene ratio dendrimer molar ratio of 1 ratio 2. Using molecular dynamics simulations we show that the strongest bi
The E. coli protein WrbA is an FMN-dependent NAD(P)H: quinone oxidoreductase that has been implicated in oxidative defense. Three subunits of the tetrameric enzyme contribute to each of four identical, cavernous active sites that appear to accommodate NAD(P)H or various quinones, but not simultaneously, suggesting an obligate tetramer with a ping-pong mechanism in which NAD departs before oxidized
Aim. Plasma total adiponectin is a marker of insulin resistance, but its role in predicting cardiovascular events is unclear. We aimed to investigate the role of adiponectin as a predictor of cardiovascular risk in middle-aged men, and to describe the association between adiponectin and glucose metabolism. Methods. In this population-based prospective study of middle-aged men (n=3885), total adipo
In this paper, we study minimal problems related to dual microphone rig self-calibration using TOA measurements from sound sources with unknown positions. We consider the problems with varying setups as (i) if the internal distances between the microphone nodes are known a priori or not. (ii) if the microphone rigs lies in an affine space with different dimension than the sound sources. Solving th
