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Retinal Glial (Müller) Cells : Sensing and responding to tissue stretch

Purpose. To test whether Müller glial cells sense, and respond to, mechanical tension in the retina. Methods. A device was designed to stretch the retina at right angles to its surface, across retinal layers. Pieces of retina were mounted between two hollow tubes, and uniaxial force was applied to the tissue using a micrometer-stepping motor. Müller cells were selectively stained with the fluoresc

Inheritance of acquired behaviour adaptations and brain gene expression in chickens

Background: Environmental challenges may affect both the exposed individuals and their offspring. We investigated possible adaptive aspects of such cross-generation transmissions, and hypothesized that chronic unpredictable food access would cause chickens to show a more conservative feeding strategy and to be more dominant, and that these adaptations would be transmitted to the offspring. Methodo

Extremely different behaviours in high and low body weight lines of chicken are associated with differential expression of genes involved in neuronal plasticity

Long-term selection (>45 generations) for low or high body weight from the same founder population has generated two extremely divergent lines of chickens, the low (LWS) and high weight (HWS) lines, which at the age of selection (56days) differs by more than nine-fold in body weight. The HWS line chickens are compulsive feeders, whereas, in the LWS line, some individuals are anorexic and others ha

Room-temperature InP/InAsP Quantum Discs-in-Nanowire Infrared Photodetectors

The possibility to engineer nanowire heterostructures with large bandgap variations is particularly interesting for technologically important broadband photodetector applications. Here we report on a combined study of design, fabrication, and optoelectronic properties of infrared photodetectors comprising four million n+–i–n+ InP nanowires periodically ordered in arrays. The nanowires were grown b

Optimization of Current Injection in AlGaInP Core−Shell Nanowire Light-Emitting Diodes

Core–shell nanowires offer great potential to enhance the efficiency of light-emitting diodes (LEDs) and expand the attainable wavelength range of LEDs over the whole visible spectrum. Additionally, nanowire (NW) LEDs can offer both improved light extraction and emission enhancement if the diameter of the wires is not larger than half the emission wavelength (λ/2). However, AlGaInP nanowire LEDs h

"The need and ability for expansion" : Conceptions of living space in the small-state geopolitics of Gudmund Hatt

Although they are often subjected to critical scrutiny, formal geopolitical practices have rarely been put on trial. One exception is the case of Gudmund Hatt (1884-1960), professor of human geography at Copenhagen University from 1929 to 1947, who was found guilty of “dishonorable national conduct” for his geopolitics during the German occupation. As a contribution to the critical history of geop

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Over the past decades, a ‘neoclassical geopolitics’ has emerged in and beyond the field of International Relations. This diverse practice reproduces many of the problems that characterised classical geopolitics, notably an excessive tendency to explain politics on the basis of ostensibly permanent geographical factors. As a contribution to the interdisciplinary dialogue between International Relat

Global, regional, and national disability-adjusted life-years (DALYs) for 315 diseases and injuries and healthy life expectancy (HALE), 1990-2015 : a systematic analysis for the Global Burden of Disease Study 2015

BACKGROUND: Healthy life expectancy (HALE) and disability-adjusted life-years (DALYs) provide summary measures of health across geographies and time that can inform assessments of epidemiological patterns and health system performance, help to prioritise investments in research and development, and monitor progress toward the Sustainable Development Goals (SDGs). We aimed to provide updated HALE a