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BACKGROUND The global prevalence of functional constipation is approximately 12%. It is characterized by infrequent complete spontaneous bowel movements (CSBMs), hard or lumpy stools, straining during defecation, and has a negative impact on quality of life (QoL). The probiotic strain Lactiplantibacillus plantarum (L. plantarum) 299v (Lp299v) has been demonstrated to be efficacious in irritable bo
Sensory input that violates prior expectations attracts attention, making unpredictability an important perceptual property to measure. In the auditory modality, knowing what sounds will be perceived as surprising, and therefore salient, is relevant both for studying vocal communication and for applied purposes such as managing noise pollution. Focusing on sequences of animal vocalizations and env
Molecular design combining biobased feedstocks, fiber processability, and reversible crosslinking is important for sustainable textiles. Herein, we report a new molecular design and synthetic strategy for partially biobased polyurethanes with tuneable chemical composition and properties, which show potential for the development of reversibly crosslinked textile fibers with enhanced recyclability.
Variation at the 17q21.31 locus, which contains the gene encoding microtubule-associated protein tau (MAPT), has been associated with neurodegenerative disorders, including Parkinson’s disease (PD). This highly complex locus is characterized by two broadly defined haplotypes: H1 and the inverted H2 haplotype. While H1 has been associated with an increased PD risk and is present in all ancestry pop
A prototype of a novel Photoemission Mask type X-ray Beam Position Monitor (PheM XBPM) for the ‘white’ undulator radiation which concept was proposed and has been built and tested. The prototype was designed and manufactured at MAX IV. Two PheM XBPMs were in-stalled at MAX IV 3 GeV storage ring at SoftiMAX and CoSAXS beamline frontends. Signal modelling, optimization and performance results of the
Purpose: Ovarian cancer is the most lethal gynecological malignancy, and chemotherapy strategies have evolved substantially over recent decades. This study aimed to evaluate whether survival outcomes of epithelial ovarian cancer (EOC) have improved over time and to explore trends in younger patients of reproductive age. Basic Procedures: We retrospectively analyzed real-world data from the Tokai O
Introduction: The seventh Åland Island Meeting on von Willebrand Disease (VWD) was held on the Åland archipelago in Finland, from 26 to 28 September 2024. Aim: The meeting brought together experts in the field of VWD from around the world to share the latest advances and knowledge in VWD. Results and Discussion: The topics covered both clinical aspects of management and biochemical and laboratory
Oral streptococci colonize the oral cavity in multispecies communities. They adhere to the salivary pellicle through surface interactions, whereafter additional bacteria and fungi are recruited to form the stable community. The oral streptococci reside as commensals in the oral cavity and contribute to homeostasis, for example, through colonization resistance. However, accumulation of bacteria at
Multipliers are key components in compute-intensive applications but incur high hardware cost. In error-tolerant domains such as image processing, approximate computing enables significant efficiency gains. This work presents a scalable approximate multiplier based on a deterministic, priority-driven partial product removal algorithm. The method assesses an extensive design-space exploration and a
RATIONALE: Information is missing on the tissue cell expression patterns of interleukin 33 (IL-33) and splice variants of the IL-33 receptor ST2 in normal and chronic obstructive pulmonary disease (COPD) lungs.OBJECTIVES: To characterize the expression patterns of IL-33, the soluble ST2 (sST2) and membrane-bound ST2 (ST2L) splice variants in the poorly studied small airway and distal lung compartm
We describe a case of allergic contact dermatitis (ACD) to Abilar (Repolar Pharmaceuticals Oy, Espoo, Finland), a wound ointment containing Picea abies (Norway spruce) resin with evidence suggesting primary sensitization.
The origin(s) of life (OoL), which has puzzled scientists for centuries, remains a major scientific challenge in the 21st century. Research on OoL spans many disciplines, including chemistry, physics, biology, planetary sciences, computer science, and mathematics. The sheer number of different scientific perspectives relevant to the problem has resulted in the coexistence of diverse tools, techniq
The aim of this paper is to discuss the ethical and legal justification of the broadly accepted ethical principle that researchers may not include adults without decision-making capacity to consent to participating in research studies if there are potential research participants with capacity who could be included instead. From the perspective of disability rights, the paper argues that this ethic
