Introduction/objective: Diagnostic delays in pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH) are related to increased morbidity and mortality. The risk of a delayed, or even a missed, diagnosis is high as the conditions are rare. The aim was to describe patients’ and spouses’ experiences of the journey from the first symptom to an established diagnos

Background: Preeclampsia (PE) is a complex pregnancy syndrome characterised by maternal hypertension and organ damage after 20 weeks of gestation and is associated with an increased risk of cardiovascular disease later in life. Extracellular haemoglobin (Hb) and its metabolites heme and iron are highly toxic molecules and several defence mechanisms have evolved to protect the tissue. Objectives: W

Katarzyna Herds bidrag synar hur fotbollssupportrar reagerat på avsaknaden av fysiska fotbollsmatcher under det gångna året. Hennesartikel behandlar hur man upprätthåller engagemang för sitt lag genom crowdfunding-kampanjer och virtuella bortamatchbussar, och ställer sig frågan hur man konsumerar fotboll när man inte kan gå på fotboll.This article is based on the lack of football activities during the global pandemic of 2020 (and unfortunately still in the beginning of 2021), focusing on a Swedish club from Stockholm called AIK (Allmänna Idrotsklubben). This lack of activities presentedin the article happened between April 2020 and March 2021.

This study contributes to debates on the efficacy of institutions in settler colonies by comparing the Cape Colony’s fiscal path to the experiences of Australia, New Zealand, and Canada. I find that the Cape’s fiscal trajectory was divergent. Agricultural and mining taxes were important surrogates of income taxes in other colonies, but the Cape’s narrow interests pushed for insulation from direct

OBJECTIVE: The present population-based study aimed to examine the association of chronic stress and sleeping difficulties with self-reported irritable bowel syndrome (IBS), gastrointestinal (GI) symptoms past 2 weeks, and psychological well-being.RESULTS: The Malmö Offspring Study included subjects from the general population to complete a questionnaire regarding sociodemographic factors, lifesty

Today's rapidly evolving and changing market dictates constant changes in design requirements during the development process of a product. If development teams are unable or unwilling to adapt to these changes, this will ultimately lead to an uncompetitive product. How the change in requirements will affect the development process depends on the complexity of the product and the development phase

Additive manufacturing (AM), which was first applied for rapid prototyping, is now becoming a real option for small-batch production of final products. Further expansion of AM is closely correlated to production costs. AM can only become competitive to traditional manufacturing methods if a product is designed for AM already from the beginning as it is an expensive technology that should only be a

Background: Previous research shows that many cancer-bereaved youths report unresolved grief several years after the death of a parent. Grief work hypothesis suggests that, in order to heal, the bereaved needs to process the pain of grief in some way. This study explored acute grief experiences and reactions in the first 6 months post-loss among cancer-bereaved teenagers. We further explored long-

Background: Palliative care focuses on identifying, from a holistic perspective, the needs of those experiencing problems associated with life-threatening illnesses. As older people approach the end of their lives, they can experience a complex series of problems that health-care professionals must identify and document in their patients’ records. Documentation is thus important for ensuring high-

Background & Aims: In 2014, the burden of hepatitis C virus (HCV) in Sweden was evaluated, to establish a baseline and inform public health interventions. Considering the changing landscape of HCV treatment, prevention, and care, and in light of the COVID-19 pandemic, this analysis seeks to evaluate Sweden's progress towards the World Health Organization (WHO) elimination targets and identify

Importance: Trastuzumab emtansine (T-DM1) is presently approved for treatment of advanced breast cancer and after incomplete response to neoadjuvant therapy, but the potential of T-DM1 as monotherapy is so far unknown. Objective: To assess pathologic complete response (pCR) to standard neoadjuvant therapy of combination docetaxel, trastuzumab, and pertuzumab (DTP) vs T-DM1 monotherapy in patients

Aims: The role of resection remains debated in cases of metastatic gastric carcinoma (mGC). Some mGCs are technically resectable. At the population level, the real-world application of resection for mGC remains largely unclear in most Western countries. This large, population-based international investigation aimed to reveal the resection patterns and trends for mGC and the treatment-associated fa

Two objects of valuation are said to be incommensurable if neither is better than the other, nor are they equally good. This negative, coarse-grained characterization fails to capture the nuanced structure of incommensurability. We argue that our evaluative resources are far richer than orthodoxy recognizes. We model value comparisons with the corresponding class of permissible preference ordering

Early after the introduction of cryosurgery to clinical practice, there were reports of metastasis regressing after cryosurgery of a primary tumour, mainly prostate and breast cancer, suggesting a systemic immunological effect to a local reaction. Colleagues within dermatology have occasionally experienced similar systemic effects following cryosurgery. However, published reports of such cases are

Background: In randomized trials, Bacille Calmette-Guérin (BCG) vaccine has been associated with reduced all-cause mortality. BCG-induced Tuberculin Skin Test (TST) reactions have also been associated with reduced all-cause mortality. We aimed to assess the association between TST responses and subsequent mortality in three birth cohorts and conducted a meta-analysis of existing studies. Methods:

The aim of this article is to examine the textual constructions of selfhood in the South African narrative There Was This Goat: Investigating the Truth Commission Testimony of Notrose Nobomvu Konile (2009), co-authored by Antjie Krog, Nosisi Mpolweni and Kopano Ratele. There Was This Goat is dedicated to understanding Mrs Konile and her Truth and Reconciliation Commission testimony given in Xhosa,

This paper analyzes The Calling of Katie Makanya (1995) by Margaret McCord as a collaborative autobiography. Katie’s motive for wanting her story to be told is not a desire to find her own voice and identity through narration, but seemingly rather to add to and complete the picture presented in the narrative My Patients Were Zulus (1946), written by Katie’s employer and Margaret McCord’s father, D