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The pathological hallmark of Parkinson’s disease (PD) is the formation of Lewy bodies containing aggregated alpha-synuclein (α-syn). Although PD is associated with these distinct histological changes, other pathological features such as microvascular alterations have been linked to neurodegeneration. These changes need to be investigated as they create a hostile brain microenvironment and may cont
Ptychographic X-ray microscopy is an ideal tool to observe chemical processes under in situ conditions. Chemical reactors, however, are often thicker than the depth of field, limiting the lateral spatial resolution in projection images. To overcome this limit and reach higher lateral spatial resolution, wave propagation within the sample environment has to be taken into account. Here, we demonstra
Sliding mode control (SMC) is to keep the system to a stable differential manifold. Model predictive control (MPC) calculates the control input by solving an optimization problem on receding horizon. The method of receding horizon sliding control (RHSC) includes the predicted information into the SMC design by combining SMC and MPC. Considering the modeling error and measurement noise, there are m
In order to mitigate global warming, it is important to decrease the climate impact from the building stock, which accounts for 39% of the GHG emissions in Europe. An extensive portion of these emissions are generated from the heating of buildings, but emissions also occur from the production of building materials. It is therefore important to find building design solutions that consider both prod
Some foreign policy analysts believe that what we are witnessing in the 21st century is nothing short of a reconfiguring of the global political order - with China firmly positioned at the helm as a (re)emerging great power. At present, the notion of the imminent establishment of a ‘new world order with Chinese characteristics’ is increasingly gaining traction. This sentiment has long permeated fo
Little is known about the impacts of persistent triazine herbicides and biocides on soil microorganisms. Terbutryn toxicity in soil microorganisms was studied using bacterial and fungal growth, substrate induced respiration (SIR) and basal respiration as ecotoxicological end-points. In the short-term (0–7 days), increasing concentrations of terbutryn (0–800 mg kg−1) progressively inhibited bacteri
The elliptic and triangular flow coefficients v2 and v3 of prompt D0, D+, and D⁎+ mesons were measured at midrapidity (|y|<0.8) in Pb–Pb collisions at the centre-of-mass energy per nucleon pair of sNN=5.02TeV with the ALICE detector at the LHC. The D mesons were reconstructed via their hadronic decays in the transverse momentum interval 1
This article explores news satire engagement and civic motivation, an area of concern in satire scholarship. Focused on what audiences ‘do’ with media, the ways in which young adults who regularly engage in news satire construct political efficacy is studied. Using a qualitative contextualising audience study, including in-depth interviews and focus groups with 31 young adults, a thematic analysis
Unicellular photosynthetic golden algae called diatoms are one of the most abundant silicifying organisms. Diatoms take up silicon and build their frustules, in the form of biogenic silica (BSi), which have high preservation potential, and thus are found in sediments. Around 27 % of the annual dissolved silicon (DSi) delivery from the land to the ocean is retained in lakes and reservoirs in the fo
This article reviews the geology of the Sveconorwegian orogen in south Scandinavia and existing tectonic models for the Mesoproterozoic to Neoproterozoic Sveconorwegian orogeny. It proposes an updated geodynamic scenario of large, hot, long-duration continental collision starting at c. 1065 Ma between proto-Baltica and another plate, presumably Amazonia, in a Rodinia-forming context. An orogenic p
We report on a novel phenomenon of particle cosmology, which features specific cosmological phase transitions via quantum tunnelings through multiple vacua. The latter is inspired by the axiverse ideas, and enables to probe the associated new physics models through a potential observation of specific patterns in the stochastic gravitational waves background. Multiple vacua may induce the nucleatio
Androgen deprivation therapy (ADT) with gonadotropin-releasing hormone (GnRH) agonists and antagonists is the mainstay of advanced prostate cancer treatment. Both drug classes decrease levels of luteinizing hormone and follicle-stimulating hormones (FSH), thereby lowering testosterone to castrate levels. This is associated with adverse events (AEs), including cardiovascular (CV) disorders, bone fr
Objectives: To explore the preoperative, intraoperative, and postoperative dynamics of heparin-binding protein (HBP) in cardiothoracic surgery. Design: This was a prospective, observational study. Setting: The study was conducted at a single university hospital. Participants: Thirty patients undergoing cardiac surgery with cardiopulmonary bypass (CPB) were included, 15 of whom underwent coronary a
The relative role of natural selection and genetic drift in evolution is a major topic of debate in evolutionary biology. Most knowledge spring from a small group of organisms and originate from before it was possible to generate genome-wide data on genetic variation. Hence, it is necessary to extend to a larger number of taxonomic groups, descriptive and hypothesis-based research aiming at unders
Genome scans in recently separated species can inform on molecular mechanisms and evolutionary processes driving divergence. Large-scale polymorphism data from multiple species pairs are also key to investigate the repeatability of divergence-whether radiations tend to show parallel responses to similar selection pressures and/or underlying molecular forces. Here, we used whole-genome resequencing
