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Background: The development of new targeted alpha therapies motivates improving alpha particle dosimetry. For alpha particles, microscopic targets must be considered to estimate dosimetric quantities that can predict the biological response. As double-strand breaks (DSB) on DNA are the main cause of cell death by ionizing radiation, cell nuclei are relevant volumes necessary to consider as targets

This article briefly discusses the notion of input in a study abroad perspective, situating it against how input is treated in second language acquisition (SLA) more broadly, with a focus on methodological issues, operationalizations, and measurements. It further introduces three studies that examine input as studied in ‘the real wild’, and two studies that instead focus on ‘the digital wild’.

Background: To achieve successful rehabilitation after hip fracture and meet patient needs it is important to listen to how individual patients perceive their situation. Purpose: The aim of this study was to explore how patients with hip fractures experience the time after hospitalization. Methods: A qualitative study was performed, data were analyzed using content analysis and included a total of

This paper investigates whether structuralist and culturalist approaches to migrant entrepreneurship can explain the early-stage entrepreneurship of recently arrived refugees. Specifically, we empirically test three hypotheses on how refugees’ current geographical location and ethnic origin matter for their entrepreneurial beliefs, which provide the cognitive and affective foundations for entrepre

Here we report large-amplitude transit timing variations (TTVs) for AU Microcopii b and c as detected in combined TESS (2018, 2020) and CHEOPS (2020, 2021) transit observations. AU Mic is a young planetary system with a debris disk and two transiting warm Neptunes. A TTV on the order of several minutes was previously reported for AU Mic b, which was suggested to be an outcome of mutual perturbatio

The application of dynamic light scattering to soft matter systems has strongly profited from advanced approaches such as the so-called modulated 3D cross correlation technique (Mod3D-DLS) that suppress contributions from multiple scattering, and can therefore be used for the characterization of turbid samples. Here we now extend the possibilities of this technique to allow for depolarized light s

Bayesian inference under a set of priors, called robust Bayesian analysis, allows for estimation of parameters within a model and quantification of epistemic uncertainty in quantities of interest by bounded (or imprecise) probability. Iterative importance sampling can be used to estimate bounds on the quantity of interest by optimizing over the set of priors. A method for iterative importance samp

Context. Gas giants orbiting close to hot and massive early-type stars can reach dayside temperatures that are comparable to those of the coldest stars. These aultra-hot Jupitersahave atmospheres made of ions and atomic species from molecular dissociation and feature strong day-to-night temperature gradients. Photometric observations at different orbital phases provide insights on the planetas atm

Framtiden är gammal. Mötet med morgondagen har sannolikt upptagit människors medvetande från allra äldsta tid. Här presenteras hela framtidens historia, från babyloniernas stjärntydningar till våra dagars hamstring och prepping. I huvudsak behandlas människors föreställningar, visioner, önskningar och rädslor inför framtiden i olika kontexter och under olika historiska epoker.

Protein-protein interactions are crucial in numerous cellular functions and biological processes that take place inside our body. It is therefore not surprising that these interactions also govern the response of our body´s defence mechanism, the so-called immune system, towards an infection. Understanding how proteins interact entails studying the binding affinity (strength) and the lifetime (dur

The use of molecular data to study the evolutionary history of organisms has revolutionized the field of systematics. Now with the appearance of high throughput sequencing (HTS) technologies, more and more genetic sequence data are available. One of the important sources of genetic data for phylogenetic analyses has been mitochondrial DNA. The limitations of mitochondrial DNA for the study of phyl

Abstract: Sensory impairments in the upper limb are common after stroke. Different sensory modalities can be affected such as sense of touch, pressure, pain, temperature and proprioception. The sensory impairments can negatively affect motor function, dexterity and the ability to perform daily activities. Despite these problems limited attention is paid to sensory impairments in stroke rehabilitat

The aim of this chapter is twofold. First, it deliberates the insufficiency of the ethnically loaded hyphenated identity of ‘Euro-Turks’ in defining the diverse diasporic community of Turkey’s citizens and/or their descendants in Europe. Second, it lays out the advantages and disadvantages of using the Türkiyeli concept as an alternative to the hyphenated identity Euro-Turks, which allows peoples

Acute respiratory distress syndrome (ARDS) is a life-threatening, high mortality pulmonary condition characterized by acute lung injury (ALI) resulting in diffuse alveolar damage. Despite progress regarding the understanding of ARDS pathophysiology, there are presently no effective pharmacotherapies. Due to the complexity and multiorgan involvement typically associated with ARDS, animal models rem

Tricuspid regurgitation (TR) is a highly prevalent condition and an independent risk factor for adverse outcomes. Multiple clinical guidelines exist for the diagnosis and management of TR, but the recommendations may sometimes vary. We systematically reviewed high-quality guidelines with a specific focus on areas of agreement, disagreement, and gaps in evidence. We searched MEDLINE and EMBASE (1 J

Plants respond to mechanical stimuli to direct their growth and counteract environmental threats. Mechanical stimulation triggers rapid gene expression changes and affects plant appearance (thigmomorphogenesis) and flowering. Previous studies reported the importance of jasmonic acid (JA) in touch signaling. Here, we used reverse genetics to further characterize the molecular mechanisms underlying

The Covid-19 pandemic has revealed the importance of social protection systems, including income security, when health problems arise. The aims of this study are to compare the follow-up regimes for sick-listed employees across nine European countries, and to conduct a qualitative assessment of the differences with respect to burden and responsibility sharing between the social protection system,

Background: Preclinical rodent models of Parkinson's aim to recapitulate some of the hallmarks of the disease as it presents in humans, including the progressive neuronal loss of dopaminergic neurons in the midbrain as well as the development of a behavioral phenotype. AAV vector-based models of alpha-synuclein overexpression are a promising tool to achieve such animal models with high face and pr