Importance: There is an urgent need for inexpensive and minimally invasive blood biomarkers for Alzheimer disease (AD) that could be used to detect early disease changes. Objective: To assess how early in the course of AD plasma levels of tau phosphorylated at threonine 217 (P-tau217) start to change compared with levels of established cerebrospinal fluid (CSF) and positron emission tomography (PE

Background: We previously found temporoparietal-predominant atrophy patterns in the behavioral variant of Alzheimer’s disease (bvAD), with relative sparing of frontal regions. Here, we aimed to understand the clinico-anatomical dissociation in bvAD based on alternative neuroimaging markers. Methods: We retrospectively included 150 participants, including 29 bvAD, 28 “typical” amnestic-predominant

In the 19th century, an extensive liberal and Christian international peace movement developed. In 1891, an umbrella organization, the International Peace Bureau (IPB), based in Bern, was formed to coordinate the international peace work that had previously been divided into a number of different national and international federations. This would prove successful. The establishment of a Nobel Priz

Type 2 diabetes (T2D) is a global public health challenge. Whilst the advent of genome-wide association studies has identified >400 genetic variants associated with T2D, our understanding of its biological mechanisms and translational insights is still limited. The EPIC-InterAct project, centred in 8 countries in the European Prospective Investigations into Cancer and Nutrition study, is one of th

Aims: Appropriate analysis of big data is fundamental to precision medicine. While statistical analyses often uncover numerous associations, associations themselves do not convey predictive value. Confusion between association and prediction harms clinicians, scientists, and ultimately, the patients. We analyzed published papers in the field of diabetes that refer to “prediction” in their titles.

In this communication, we present the phase diagram of CsPb(BrxI1-x)3 (0 ≤ x ≤ 1, 300-585 K) obtained by high-throughput in situ GIWAXS measurements of a combinatorial thin film library. We find that all compositions convert to the cubic perovskite phase at high temperature and that the presence of bromide in the films stabilizes the metastable perovskite phases upon cool down. In accordance with

Whole-genome sequencing projects are increasingly populating the tree of life and characterizing biodiversity1–4. Sparse taxon sampling has previously been proposed to confound phylogenetic inference5, and captures only a fraction of the genomic diversity. Here we report a substantial step towards the dense representation of avian phylogenetic and molecular diversity, by analysing 363 genomes from

BACKGROUND: Higher intakes of whole grains and dietary fiber have been associated with lower risk of insulin resistance, hyperinsulinemia, and inflammation, which are known predisposing factors for cancer. OBJECTIVES: Because the evidence of association with bladder cancer (BC) is limited, we aimed to assess associations with BC risk for intakes of whole grains, refined grains, and dietary fiber.

We analyze the size evolution of pebbles accreted into the gaseous envelope of a protoplanet growing in a protoplanetary disk, taking into account collisions driven by the relative sedimentation speed as well as the convective gas motion. Using a simple estimate of the convective gas speed based on the pebble accretion luminosity, we find that the speed of the convective gas is higher than the sed

The detections of 1I/‘Oumuamua and 2I/Borisov within just two years of each other impressively demonstrate that interstellar objects (ISOs) must be common in the Milky Way. Once released from their parent system, these ISOs travel for billions of years through interstellar space. While often imagined as empty, interstellar space contains gas and dust most prominent in the form of molecular clouds.

OBJECTIVE: To investigate the association between discordant β-amyloid (Aβ) PET and CSF biomarkers at baseline and the emergence of tau pathology 5 years later. METHODS: We included 730 Alzheimer's Disease Neuroimaging Initiative (ADNI) participants without dementia (282 cognitively normal, 448 mild cognitive impairment) with baseline [18F]florbetapir PET and CSF Aβ42 available. Aβ CSF/PET status

The cross section of bottom quark-antiquark (bb¯) production in p+p collisions at s=510 GeV is measured with the PHENIX detector at the Relativistic Heavy Ion Collider. The results are based on the yield of high mass, like-sign muon pairs measured within the PHENIX muon arm acceptance (1.21 GeV/c, and dimuon mass of 5-10 GeV/c2. The extrapolated total cross section at this energy for bb¯ productio

Spontaneous formation of vesicles from the self-assembly of two specific surfactants, one zwitterionic (oleyl amidopropyl betaine, OAPB) and the other anionic (Aerosol-OT, AOT), is explored in water using small-angle scattering techniques. Two factors were found to be critical in the formation of vesicles: surfactant ratio, as AOT concentrations less than equimolar with OAPB result in cylindrical

Nanoscale X-ray detectors could allow higher resolution in imaging and diffraction experiments than established systems but are difficult to design due to the long absorption length of X-rays. Here, we demonstrate X-ray detection in a single nanowire in which the nanowire axis is parallel to the optical axis. In this geometry, X-ray absorption can occur along the nanowire length, while the spatial

Aim: Research is lacking in terms of reading decoding skills among clinical samples of Swedish-speaking children with Developmental Language Disorder (DLD). Method: The present cross-sectional study included a sample of 61 children (8-12 years) with DLD attending school language units, years 1 to 5. Our purpose was to study reading decoding skills and predictors for decoding, such as a phonologica

Two new Eulophinae genera, Elasmarion and Celesterion, are described based on material from sweep-net and malaise trap samples mainly from Costa Rica. The new genera are each represented by a single species, both described here, E. longipes and C. reticulatum spp. nov. The material for both groups is abundant and strongly female biased, 119 females and two males in Elasmarion, and 63 females and t

As cardio metabolic disease manifestations tend to cluster in families there is a need to better understand the underlying mechanisms in order to further develop preventive strategies. In fact, genetic markers used in genetic risk scores, important as they are, will not be able alone to explain these family clusters. Therefore, the search goes on for the so called missing heritability to better ex

The COVID-19 pandemic is classified as an infodemic with the circulation of vast amounts of true and untrue information, especially through social media. The study’s aim was to explore different articulations of people’s understanding, handling and evaluation of (true) information, misinformation and disinformation in general and specifically linked to social media related to the COVID-19 pandemicThe COVID-19 pandemic is classified as an infodemic with the circulation of vast amounts of true and untrue information, especially through social media. The study’s aim was to explore different articulations of people’s understanding, handling and evaluation of (true) information, misinformation and disinformation in general and specifically linked to social media related to the COVID-19 pandemic

With the improvement of treatments, a growing number of survivors with childhood or adolescent central nervous system (CNS) tumor are parenting their own children. We aimed to explore the risk of somatic diseases among children of these survivors compared with population controls. Children of survivors with CNS tumor below age of 20 were identified between 1973 and 2014 by combining the several Sw

We present the first one-step acoustic separation of high quality plasma and mononuclear cells (MNCs) from undiluted human whole blood. This enables centrifugation-free integration in analytical instrumentation.