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Aquaglyceroporin 7 (AQP7) facilitates glycerol flux across the plasma membrane with a critical physiological role linked to metabolism, obesity, and associated diseases. Here, we present the single-particle cryo-EM structure of AQP7 determined at 2.55 Å resolution adopting two adhering tetramers, stabilized by extracellularly exposed loops, in a configuration like that of the well-characterized in
Starch modified with octenyl succinic anhydride (OSA) is extensively used due to its emulsifying capacity. Modification with OSA renders the starch surface active but also anionic at intermediate pH. The amount of OSA that is grafted to the starch polymer backbone will influence the functionality. Likewise, it can be expected that the distribution of the substituents over the molar mass distributi
BACKGROUND: Movement disorders are frequent in patients with inborn errors of metabolism (IEMs) but poorly recognized, particularly by nonmovement disorder specialists. We propose an easy-to-use clinical screening tool to help recognize movement disorders.OBJECTIVE: The aim is to develop a user-friendly rapid screening tool for nonmovement disorder specialists to detect moderate and severe movemen
Ensuring the conditions for an inclusive society in the face of humandiversity places various demands on the built environment. Planning isessential for accommodating a wide range of individual preferences andabilities.This article examines the presence and absence of Universal Design (UD)in contemporary urban planning and construction in eight new or remodelledSwedish building and public space pr
Direct oral anticoagulants (DOACs) require perioperative vigilance to reduce the risk of spinal haematoma. There is a little of information concerning which plasma concentrations of DOACs are safe when administering central neuraxial blocks (CNBs) and there is a wide variability in the rate of elimination, both between individuals and DOACs.
Introduction: Understanding symptom patterns in atrial fibrillation (AF) can help in disease management. We report on the application of natural language processing (NLP) to electronic medical records (EMRs) to capture symptom reports in patients with newly diagnosed (incident) AF. Methods and Results: This observational retrospective study included adult patients with an index diagnosis of incide
Type 2 diabetes (T2D) is caused by insufficient insulin secretion from pancreatic β-cells. To identify candidates contributing to T2D pathophysiology, we studied human pancreatic islets from ~300 individuals. We found 395 differentially expressed genes (DEGs) in islets from individuals with T2D, including, to our knowledge, novel (OPRD1, PAX5, TET1) and previously identified (CHL1, GLRA1, IAPP) ca
Little is known about the neural basis of lower and higher-order olfactory functions such as odor memory, compared with other sensory systems. The aim of this study was to explore neural networks and correlates associated with three functions: passive smelling (PS), odor encoding (OE) and in particular odor recognition memory (ORM). Twenty-six healthy participants were examined using fMRI conducte
By drawing from recent progress in AI, this chapter scrutinises implications of a specific imaginary of automated futures: the possible resurrection of the dead. Necrorobotics is proposed as a field of critical studies on the use of data and design based on one specific dead individual in order to “resurrect” that individual. That is, to mimic or create some level of robotic agency for the sake of
