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There is increasing evidence of an interaction between the nervous and the immune systems. The aim of this study was to investigate the rôle of calcitonin gene-related peptide (CGRP) in the modulation of the elicitation of immediate and delayed, immunological and non-immunological reactions in human skin. CGRP (13 pmol and 39 pmol), and the CGRP-antagonist, CGRP/8-37/, (50 pmol and 500 pmol) were
Negative ions homologous to N- are interesting systems, since there are several bound terms within the ground configuration. The forbidden transitions between them, often dominated by the magnetic dipole contributions, are affected by term mixing - a relativistic effect. When increasing the nuclear charge in the homologous sequence of negative ions, this effect increases. In this paper we use syst
Complications of diabetes include sensory and autonomic neuropathy. The aim of the present paper was to study the degree of sensory and autonomic neuropathy and correlate these findings with the distribution and density of neuropeptidergic nerve fibers in the skin of the forearm of diabetic patients and healthy controls. We investigated 30 diabetics (24 type 1 and 6 type 2) and compared them with
A 55-year-old woman developed an airborne dermatitis on her face. Patch testing was performed and showed positive reactions to formaldehyde, thiuram mix, carba mix, and nickel sulphate. She operated a machine at work in which polyacetal granules were heated. The presence of formaldehyde in the pyrolysis smoke from the polymer was confirmed by chemical analysis.
The upper Middle to basal Upper Ordovician succession (Darriwilian to Sandbian) of the Fågelsång-3 drill core provides new important information on the graptolite biostratigraphy of Scania, southern Sweden. The Scanian succession is known largely from drill cores and a few scattered outcrops exposing only parts of the interval. The Darriwilian Almelund Shale Formation overlies the Komstad Limeston
Two men employed as painters and paperhangers showed a long-standing contact dermatitis of the hands and nummular eczema of the arms and legs. Patch testing using the standard series yielded a positive reaction to Kathon CG. Concomitant contact allergy to 1,2-benzisothiazolin-3-one was found in both patients. The occurrence of 1,2-benzisothiazolin-3-one was not declared on all of the paints to whi
Junior partners in a coalition government are torn between an eagerness to profile themselves, and to show loyalty to the coalition. We investigate when, how and why junior coalition parties affect foreign policy and profile themselves despite demands for national unity. We study two Swedish centre-right governments in 2006–2010 and 2010–2014. The parties' foreign policy positions in election mani
Substance P (SP), neurokinin A (NKA) and calcitonin gene-related peptide (CGRP) coexist in nerve fibres in the skin. CGRP causes erythema upon intracutaneous injection. The erythema is independent of axon reflexes and release of mast cell histamine. SP is known to produce a flare reaction that is dependent on axon reflexes and release of mast cell histamine. The flare reaction to NKA is known to d
Proteins of the serpin family (serine protease inhibitor) control key steps in the inflammatory, coagulation and complement systems. C1‐inhibitor deficiency predisposes to hereditary angioneurotic oedema, and other serpins control proteolytic enzymes that may cause complement activation or the forming of oedema. We investigated whether deficiency of proteins of the serpin family may predispose to
Det var en begivenhedsrig uge, den Hollandske musikfestival November Music i år faldt sammen med. Trump havde netop vundet det amerikanske præsidentvalg, og verden viste sig at være andet end det mange af os troede, den var, da vi gik i seng den skæbnesvangre tirsdag aften. Begivenheden satte sig i min krop, som en oplevelse af, at den verden jeg kendte på overraskende vis nu var ved at gå i opløs
The actions and interactions of putative mediators of inflammation, such as substance P (SP), histamine, bradykinin and prostaglandins (PGE2) were studied in human skin. In addition, the effects of capsaicin were examined as it is known to release (and to deplete) SP and calcitonin gene-related peptide from C-fibres. The flare evoked by bradykinin was abolished by pretreatment with lignocaine (loc
Guinea pigs were sensitized to dinitrochlorobenzene (DNCB) by the intracutaneous route and challenged epicutaneously tin the flanks. The intensity of the allergic contact dermatitis was evaluated by inspection and palpation as well us by wet weight determination. With the purpose of diminishing tissue neuropeptides, and substance P in particular, the animals were treated with capsaicin either betw
The role of substance P (SP) in allergic reactions of the skin was investigated. Spantide, a competitive inhibitor of SP, was injected intracutaneously into the volar aspect of the forearm prior to the following challenges: benzalkonium chloride (irritant delayed reaction), tuberculin (immunological delayed reaction), UVB irradiation, benzoic acid (non-immunological contact urticaria), different f
Objective: To evaluate trends in bladder cancer incidence, survival and mortality in Sweden from 1997–2016. Patients and methods: The Swedish National Registry of Urinary Bladder Cancer is a nation-wide quality register that started in 1997. It includes information on initial tumor characteristics and treatment; 41,097 new cases were registered up to 2016. Patients were stratified into four time p
Chromium(Cr) poisoning of the traditional LSM cathode is one of the most critical issues that accounts for instability of solid oxide fuel cells (SOFCs). The poisoning course will introduce alien species in the cathode active regions and it causes phase change and structure deformation, reducing the sites for electrochemical reactions. A 3D model is thus developed by coupling the computational flu
