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Background: The growth factor progranulin has been implicated in numerous biological processes such as wound healing, inflammation and progressive tumorigenesis. Both progranulin and its receptor sortilin are known to be highly expressed in subgroups of breast cancer and have been associated with various clinical properties including tamoxifen resistance. Recent data further suggest that progranul
Andelen unga som beviljas förtidspension under lång tid har ökat, särskilt de med en psykisk diagnos eller unga med lindrig psykisk ohälsa. Denna form av utanförskap innebär att betydande andelar av en generation av unga människor har liten eller ingen koppling till arbetsmarknaden under en större del av sitt vuxna liv.Bara i Sverige har antalet förtidspensionerade mellan 19-29 år fördubblats unde
An increase in dopamine (DA) synthesis capacity in the dorsal striatum (DS) during the prodromal stage of schizophrenia becomes more pronounced as patients progress to the full disorder. Understanding this progression is critical to intervening in disease course. We developed an animal model—Enhanced Dopamine in Prodromal Schizophrenia (EDiPS)—which uses a genetic construct to increase DA synthesi
Presentation of the Filmform Foundation and its archive of experimental film and video, at the website filmarkivet.se, directed by Swedish Film Institute.
Adjuvant systemic therapies are now routinely used following resection of stage III melanoma, however accurate prognostic information is needed to better stratify patients. We use differential expression analyses of primary tumours from 204 RNA-sequenced melanomas within a large adjuvant trial, identifying a 121 metastasis-associated gene signature. This signature strongly associated with progress
Most of the drugs currently prescribed for cancer treatment are riddled with substantial side effects. In order to develop more effective and specific strategies to treat cancer, it is of importance to understand the biology of drug targets, particularly the newly emerging ones. A comprehensive evaluation of these targets will benefit drug development with increased likelihood for success in clini
Noise pollution is a growing global public health concern. Among other issues, it has been linked with sleep disturbance, hearing functionality, increased blood pressure and heart disease. Individuals are increasingly using social media to express complaints and concerns about problematic noise sources. This behavior-using social media to post noise-related concerns-might help us better identify t
Quenching of vibrational excitations in resonant inelastic X-ray scattering (RIXS) spectra of liquid acetic acid is observed. At the oxygen core resonance associated with localized excitations at the O–H bond, the spectra lack the typical progression of vibrational excitations observed in RIXS spectra of comparable systems. We interpret this phenomenon as due to strong rehybridization of the unocc
Irrigation is the largest sector of human water use and an important option for increasing crop production and reducing drought impacts. However, the potential for irrigation to contribute to global crop yields remains uncertain. Here, we quantify this contribution for wheat and maize at global scale by developing a Bayesian framework integrating empirical estimates and gridded global crop models
Breast cancer (BC) risk for BRCA1 and BRCA2 mutation carriers varies by genetic and familial factors. About 50 common variants have been shown to modify BC risk for mutation carriers. All but three, were identified in general population studies. Other mutation carrier-specific susceptibility variants may exist but studies of mutation carriers have so far been underpowered. We conduct a novel case-
Reducing the complexity of decoding algorithms for LDPC codes is an important prerequisite for their practical implementation. In this work we propose a reduction of computational complexity targeting the highly reliable codeword bits and show that this approach can be seamlessly merged with the forced convergence scheme. We also show how the minimum achievable complexity of the resulting scheme f
The uncertainties over how to interpret European Foreign Policy (EFP), understood as the nexus between European Union and member state foreign policies, are multiplied in a more global era reconfigured by globalizing, multilateralizing and multipolarizing processes. In order to make greater sense of EFP in a global political-cultural context, this chapter will consider the ways in which political
Fuel cells are highly efficient and green power sources. The typical membrane electrode assembly is necessary for common electrochemical devices. Recent research and development in solid oxide fuel cells have opened up many new opportunities based on the semiconductor or its heterostructure materials. Semiconductor-based fuel cells (SBFCs) realize the fuel cell functionality in a much more straigh
Two experiments involving an international collaboration ofexperimenters sought to replicate and extend a previously publishedpsi experiment on precognition by Daryl Bem that has been the focusof extensive research. The experiment reverses the usual cause–e! ectsequence of a standard psychology experiment using priming and reactiontimes. The preregistered con" rmatory hypothesis is that response t
Correlation between different links is an essential characteristic for many of the forthcoming radio communication systems that utilize the multiple-input-multiple-output (MIMO) technology. This paper investigates the physical phenomena that cause the inter-link correlation by introducing a measure to quantify how large amount of energy propagates via similar propagation mechanisms in different li
